Lifeboat Foundation

(https://isbscience.org/bio/leroy-hood/) is Co-Founder, Chief Strategy Officer and Professor, at the Institute of Systems Biology (ISB) in Seattle, as well as CEO of Phenome Health (https://phenomehealth.org/), a nonprofit organization dedicated to delivering value through health innovation focused on his P4 model of health (Predictive, Preventive, Personalized and Participatory) where a patient’s unique individuality is acknowledged, respected, and leveraged for the benefit of everyone.

Dr. Hood, who is a world-renowned scientist and recipient of the National Medal of Science in 2011, co-founded the Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000–2017. In 2016, ISB affiliated with Providence St. Joseph Health (PSJH) and Dr. Hood became PSJH’s Senior Vice President and Chief Science Officer.

Continue reading “Dr. Leroy Hood, MD, Ph.D. — Co-Founder, Institute of Systems Biology (ISB); CEO, Phenome Health” »

EPFL researchers have created novel protein binders that can seamlessly attach to important targets, including the spike protein of SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the official name of the virus strain that causes coronavirus disease (COVID-19). Previous to this name being adopted, it was commonly referred to as the 2019 novel coronavirus (2019-nCoV), the Wuhan coronavirus, or the Wuhan virus.

Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke.

A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has found a non-invasive and non-pharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function. Results of the work are published in the Proceedings of the National Academy of Sciences on May 15.

Hong Chen, associate professor of biomedical engineering in McKelvey Engineering and of neurological surgery in the School of Medicine, and her team, including Dezhuang (Summer) Ye, a postdoctoral research associate, and Si (Stacie) Chen, a former postdoctoral research associate, found the first direct evidence that focused ultrasound, combined with circulating microbubbles—a technique they call FUSMB—could mechanically enhance glymphatic transport in the mouse brain.

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Imagine having a building made of stacks of bricks connected by adaptable bridges. You pull a knob that modifies the bridges and the building changes functionality. Wouldn’t it be great?

A team of researchers led by Prof. Aitor Mugarza, from the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and ICREA, together with Prof. Diego Peña from the Center for Research in Biological Chemistry and Molecular Materials of the University of Santiago de Campostela (CiQUS-USC), Dr. Cesar Moreno, formerly a member of ICN2’s team and currently a researcher at the University of Cantabria, and Dr. Aran Garcia-Lekue, from the Donostia International Physics Center (DIPC) and Ikerbasque Foundation, has done something analogous, but at the single-atom scale, with the aim of synthesizing new carbon-based materials with tunable properties.

Continue reading “Engineering graphene-based quantum circuits with atomic precision” »

Jiangnan University, via SCMP

Ceramics are commonly used in the fields of electronics, mechanical engineering, and aerospace because of their structural integrity. They are also common because they are resistant to wear while also having endurance to high temperatures. Yet, because of their brittleness and hardness, designing and manufacturing certain ceramic parts.

Distributed denial-of-service (DDoS) attacks are growing in frequency and sophistication, thanks to the number of attack tools available for a couple of dollars on the Dark Web and criminal marketplaces. Numerous organizations became victims in 2022, from the Port of London Authority to Ukraine’s national postal service.

Security leaders are already combating DDoS attacks by monitoring network traffic patterns, implementing firewalls, and using content delivery networks (CDNs) to distribute traffic across multiple servers. But putting more security controls in place can also result in more DDoS false positives — legitimate traffic that’s not part of an attack but still requires analysts to take steps to mitigate before it causes service disruptions and brand damage.

Rate limiting is often considered the best method for efficient DDoS mitigation: URL-specific rate limiting prevents 47% of DDoS attacks, according to Indusface’s “State of Application Security Q4 2022” report. However, the reality is that few engineering leaders know how to use it effectively. Here’s how to employ rate limiting effectively while avoiding false positives.

Northwestern investigators have demonstrated that fine-tuning DNA interaction strength can improve colloidal crystal engineering to enhance their use in creating an array of functional nanomaterials, according to a recent study published in ACS Nano.

Chad Mirkin, Ph.D., professor of Medicine in the Division of Hematology and Oncology, the George B. Rathmann Professor of Chemistry at Northwestern’s Weinberg College of Arts and Sciences, and director of the International Institute for Nanotechnology, was senior author of the study.

Colloidal crystal engineering with DNA involves modifying nanoparticles into programmable atom equivalents, or “PAEs,” which are used to form colloidal crystals that can then be used for designing programmable, synthetic DNA sequences.

But Dituri isn’t just settling for the record and resurfacing: He plans to stay at the lodge until June 9, when he reaches 100 days and completes an underwater mission dubbed Project Neptune 100.

The mission combines medical and ocean research along with educational outreach and was organized by the Marine Resources Development Foundation, owner of the habitat.

“The record is a small bump and I really appreciate it,” said Dituri, a University of South Florida educator who holds a doctorate in biomedical engineering and is a retired U.S. Naval officer. “I’m honored to have it, but we still have more science to do.”

Scientists from Jilin University, the Center for High Pressure Science and Technology Advanced Research, and Skoltech have synthesized lanthanum-cerium polyhydride, a material that promises to facilitate studies of near-room-temperature superconductivity. It offers a compromise between the polyhydrides of lanthanum and cerium in terms of how much cooling and pressure it requires. This enables easier experiments, which might one day lead scientists to compounds that conduct electricity with zero resistance at ambient conditions—an engineering dream many years in the making. The study was published in Nature Communications.

One of the most intriguing unsolved questions in modern physics is: Can we make a material that conducts electricity with zero resistance (superconducts) at room temperature and atmospheric pressure? Such a superconductor would enable power grids with unprecedented efficiency, ultrafast microchips, and electromagnets so powerful they could levitate trains or control fusion reactors.

In their search, scientists are probing multiple classes of materials, slowly nudging up the temperature they superconduct at and decreasing the pressure they require to remain stable. One such group of materials is polyhydrides—compounds with extremely high hydrogen content. At −23°C, the current champion for high-temperature superconductivity is a lanthanum polyhydride with the formula LaH₁₀. The trade-off: It requires the pressure of 1.5 million atmospheres. At the opposite end of the spectrum, cuprates are a class of materials that superconduct under normal atmospheric pressure but require cooler temperatures —no more than −140°.