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Clearing Damaged Mitochondria to Fight Skin Photoaging

Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced skin aging (photoaging) in mice by restoring their cells’ ability to get rid of their own damaged mitochondria (mitophagy).

Wrinkles are only a small part of the problem

Chronic exposure to ultraviolet light is the main driver of photoaging, which is characterized by the accumulation of senescent cells in the skin along with the depletion of DNA-protecting lamins [1]. It causes skin to become thickened, wrinkled, and rough while accumulating visible veins [2]. This damage is more than cosmetic; photoaging can lead to precancerous lesions along with cancer itself [3]. Retinoids and other antioxidants have been found to have some effects but cannot completely reverse this damage [4], and laser-based treatments may be expensive and painful while causing other symptoms [5].

MOLOCH | Official Teaser Trailer HD | When AI Replaces Us All

MOLOCH — Premiering 29 September on Omeleto.

Subscribe so you don’t miss it: / @omeleto.

As the technology she built rips her family apart and triggers worldwide job loss, an AI engineer battles spiritual forces — and the CEO of her own company — to pull the plug.

Everyone sees the danger. No one can afford to stop.

Starring Fiona Hampton, Parker Sawyers, David Buttle, and Buddy Wignall-Ho.
Written & directed by Tom Cozens.
An Owl In Space production in collaboration with the Future of Life Institute.

#Moloch #ShortFilm #SciFi #AI #AISafety #Superintelligence #Omeleto

Continue reading “MOLOCH | Official Teaser Trailer HD | When AI Replaces Us All” | >

Google cofounder Larry Page’s wife, a Stanford-trained scientist, has built an ocean-tech organisation; company has donated $120 million-plus in science projects

Around the world, ultra-wealthy individuals and institutions are pouring massive fortunes into projects designed to heal the planet. One of them is Lucinda Southworth, wife of Google co-founder Larry Page, a Stanford-trained scientist and one of the most prolific backers of high-tech ocean conservation.

Insilico Medicine AI Drug Rentosertib Cuts Biological Age on Six Independent Protein Clocks

Didn’t say by how much unless I skimmed over it.

Not proven yet. The study found a coordinated shift in blood proteins associated with younger predicted biological age in treated IPF patients. It cannot prove the drug reversed the aging process itself, because all study participants had IPF — a disease that alters the very protein patterns the clocks are trained on. The critical next test, which Nobel laureate Michael Levitt explicitly named, is a trial in healthy volunteers without IPF. If the biological age signal persists in people without the disease confound, the case for systemic geroprotective activity becomes substantially stronger. The ongoing Phase III trial in IPF (320 patients, 47 centers in China) is designed to assess lung function, not aging per se — but its larger sample may provide additional proteomic data over a longer time horizon.

What makes rentosertib different from other longevity drugs like rapamycin or metformin?

Rapamycin, metformin, and the senolytic combination dasatinib plus quercetin are repurposed drugs: they were developed for other indications (organ transplant, diabetes, and cancer, respectively) and discovered through subsequent research to interact with aging-relevant pathways. None was designed with aging biology as the primary specification. Rentosertib was. Insilico’s AI platform scored TNIK — the drug’s molecular target — against the 12 hallmarks of aging framework, found it relevant to six hallmarks, and designed a molecule specifically to inhibit it. That makes rentosertib, if its geroprotective effects are confirmed in further studies, the first drug created from scratch specifically for the biology of aging to produce a clinical signal in humans.

AI Pioneer Andrew Ng Calls Extinction Fears ‘Science Fiction’

Artificial intelligence pioneer Andrew Ng said warnings about existential AI risks from researchers at top model makers are “science fiction” that may be detrimental to ensuring the technology’s maximum benefits to society.

Ng, who helped start Google Brain and Coursera Inc., said the tech industry previously stoked fears about the potential catastrophic harms of artificial intelligence earlier in the AI boom in an apparent bid to bolster publicity and shape regulation.

A single IV treatment retrains immune cells to fight autoimmune diseases in early trial

CAR T-cell therapy is an immune-reprogramming procedure that turns a patient’s own immune cells into cancer-fighting specialists. The entire process is complex, but researchers have now found a faster way to achieve similar effects using a single intravenous (IV) drip of a harmless engineered virus.

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