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Category: life extension

New brain atlas offers unprecedented detail in MRI scans

The human brain comprises hundreds of interconnected regions that drive our thoughts, emotions, and behaviours. Existing brain atlases can identify major structures in MRI scans – such as the hippocampus, which supports memory and learning – but their finer sub-regions remain hard to detect. These distinctions matter because sub-regions of areas like the hippocampus, for example, are affected differently during Alzheimer’s disease progression.

Examining the brain at the cellular level is achievable using microscopy (histology), but cannot be done in living individuals, limiting its potential for understanding how the human brain changes during development, ageing and disease.

Published in Nature, the new study introduces NextBrain, an atlas of the entire adult human brain that can be used to analyse MRI scans of living patients in a matter of minutes and at a level of detail not possible until now.

The creators of the atlas, which is freely available, hope it will ultimately help to accelerate discovery in brain science and its translation into better diagnosis and treatment of conditions such as Alzheimer’s.

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Japan’s vision for AI robots to empower humans

What if instead of replacing us in our jobs, AI-enabled robots were to help us become the best versions of ourselves? Prompted by the ageing crisis and a projected shortfall of carers, a research team in Japan is seeking to create a new robotic paradigm, where AI-enabled robots help us to help ourselves.

“By 2050, I’d like to realize a smarter, more inclusive society, where everyone will be able to use AI robots anytime and anywhere,” says Yasuhisa Hirata, a mechanical engineer at Tohoku University in Sendai, Japan1. Hirata is the project manager on the ‘Adaptable AI-enabled Robots to Create a Vibrant Society’ project of the Japanese Government’s Moonshot Research and Development Program.

He envisages future AI-enabled robots functioning somewhere between a carer and a coach — a tool that can provide support, but which makes users feel as though they are performing tasks independently rather than being assisted by a robot. Such tasks might range from people standing up out of a chair, lifting a heavy object, or expressing themselves through dance.

We doubled human lifespans in the last 200 years. Can we do it again? | Andrew Steele

“Over the last 10 or 15 years, scientists have really started to understand the fundamental underlying biology of the aging process. And they broke this down into 12 hallmarks of aging.”

Up next, Why 2025 is the single most pivotal year in our lifetime | Peter Leyden ► • Why 2025 is the single most pivotal year i…

We track age by the number of birthdays we’ve had, but scientists are arguing that our cells tell a different, more truthful story. Our biological age reveals how our bodies are actually aging, from our muscle strength to the condition of our DNA.

The gap between these two numbers may hold the key to treating aging – which could help save 100,000 lives per day and win us $38 trillion dollars.

00:00 Rethinking longevity.
01:27 Understanding aging.
02:58 Biological age and epigenetics.
04:29 New frontiers in longevity science.
08:04 Future possibilities and ethical questions.
10:24 The moral debate around living longer.

‘Young’ Immune Cells Partly Reverse Alzheimer’s Symptoms in Mice

Specially engineered ‘young’ immune cells could help to reverse the effects of aging and the damage to brain cells caused by diseases such as Alzheimer’s, according to a new study in mice.

In their natural state, these immune cells are known as mononuclear phagocytes, and they flow around the body, cleaning up waste.

As we get older, however, these immune-cell cleaners get a bit sloppy, clearing away less cellular debris and triggering more inflammation than before. Inflammation and protein aggregation are features of many age-related diseases, including Alzheimer’s.

The Future of Aging: How Science Could Prevent You From Growing Old

Most people accept aging as inevitable. Aubrey de Grey refuses to.

In this episode, the world’s most recognized longevity scientist breaks down why aging is a solvable engineering problem — not a mystery of biology.

Aubrey shares the moments that shaped his mission to defeat death, the science behind “longevity escape velocity”, and how AI breakthroughs like AlphaFold are accelerating humanity’s fight against aging.

He also reveals what he actually does to stay biologically younger at 62 — from cutting-edge diagnostics to his take on rapamycin, plasma exchange, GLP-1s, and Brian Johnson’s Blueprint.

If you’re a founder, technologist, or anyone fascinated by the future of the human body — this conversation will completely reframe how you think about aging, biology, and time itself.

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A gene from 100-year-olds could help kids who age too fast

Scientists have uncovered a breakthrough in the fight against a rare genetic condition that causes children to age much faster than normal. The discovery involves “longevity genes” found in people who live exceptionally long lives, often beyond 100 years. Researchers from the University of Bristol and IRCCS MultiMedica found that these genes, which help maintain the health of the heart and blood vessels during aging, could reverse some of the damage caused by this devastating disease.

The study, published in Signal Transduction and Targeted Therapy, is the first to show that a gene from long-lived individuals can slow down heart aging in a model of Progeria. Known scientifically as Hutchinson-Gilford Progeria Syndrome (HGPS), this rare and fatal disorder causes children to exhibit signs of “accelerated aging.”

Progeria stems from a mutation in the LMNA gene, which leads to the creation of a harmful protein called progerin. This protein disrupts normal cell function, particularly in the heart and blood vessels. Most affected children die in their teenage years from heart complications, though some, like Sammy Basso — the oldest known person with Progeria — live longer. Sammy passed away on October 24, 2024, at the age of 28.

Scientists Have Discovered a Way to Boost Memory in Aging Brains

Virginia Tech scientists found that age-related memory loss stems from molecular changes in the brain. Memory decline might not be just a natural part of aging. Researchers at Virginia Tech have discovered that it is connected to particular molecular changes in the brain, and that fine-tuning these

How just minutes of running can supercharge your health

Interval running condenses the powerful effects of regular running into shorter, high-intensity bursts. Research shows it can improve cardiovascular health, regulate blood sugar, and reduce body fat more effectively than longer steady runs. Just a few short sprints per session can deliver major fitness gains.

Running offers a wide range of advantages for both body and mind. It can protect against disease, improve mood, and even slow down the body’s natural aging process.

Yet about 31% of adults still don’t get enough physical activity, including running. The most common reason people give is simple — they don’t have enough time.

HUMAN Stem Cells Have Reversed Age In Monkey’s with ZERO Side Effects

Age Reversal in Primates has been achieved. We have it now.

Anti-aging gene therapy, stem cell rejuvenation, and FOXO3 longevity research take center stage in this episode of Longevity Science News with Emmett Short. This groundbreaking study out of Beijing shows that gene-edited human stem cells—specifically FOXO3-enhanced senescence-resistant mesenchymal progenitor cells (SRCs)—can reverse biological aging in elderly monkeys, restoring youthful brain structure, bone density, immune strength, and even ovarian function. By upgrading the FOXO3 longevity gene, scientists created stem cells that resist cellular senescence, DNA damage, and oxidative stress, effectively making the monkeys younger from the inside out. MRI scans revealed increased cortical thickness and improved memory-related connectivity, while biological age clocks showed a 3–5 year reversal across 54% of tissues—equivalent to 9–15 years of human rejuvenation. Emmett explains how these anti-aging stem cells, epigenetic resets, and exosome-based rejuvenation pathways could revolutionize regenerative medicine, longevity biotech, and future human trials. He also explores the costs, ethics, and long-term implications of turning back time at the cellular level. If you’re passionate about biohacking, gene editing, lifespan extension, or the future of anti-aging science, this is the video for you.

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Watch next: Artificial Blood: The SciFi Anti-Aging Tech That’s Now in Human Trials.
https://www.youtube.com/watch?v=3xz1lcGdQPc.

If you’re into the cutting edge of anti-aging science, subscribe and share with someone who wants to live longer, healthier, and stronger.

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