Lifeboat Foundation

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Continue reading “Intimations of Imitations: Visions of Cellular Prosthesis & Functionally-Restorative Medicine” »

This essay was also published by the Institute for Ethics & Emerging Technologies and by Transhumanity under the title “Is Price Performance the Wrong Measure for a Coming Intelligence Explosion?”.

Introduction

Most thinkers speculating on the coming of an intelligence explosion (whether via Artificial-General-Intelligence or Whole-Brain-Emulation/uploading), such as Ray Kurzweil [1] and Hans Moravec [2], typically use computational price performance as the best measure for an impending intelligence explosion (e.g. Kurzweil’s measure is when enough processing power to satisfy his estimates for basic processing power required to simulate the human brain costs $1,000). However, I think a lurking assumption lies here: that it won’t be much of an explosion unless available to the average person. I present a scenario below that may indicate that the imminence of a coming intelligence-explosion is more impacted by basic processing speed – or instructions per second (ISP), regardless of cost or resource requirements per unit of computation, than it is by computational price performance. This scenario also yields some additional, counter-intuitive conclusions, such as that it may be easier (for a given amount of “effort” or funding) to implement WBE+AGI than it would be to implement AGI alone – or rather that using WBE as a mediator of an increase in the rate of progress in AGI may yield an AGI faster or more efficiently per unit of effort or funding than it would be to implement AGI directly.

Loaded Uploads:

Continue reading “How Could WBE+AGI be Easier than AGI Alone?” »

Artifacts, Artifictions, Artifutures 0.5

It’s not a physical landscape. It’s a term reserved for the new technologies. It’s a landscape in the future. It’s as though you used technology to take you off the ground and go like Alice through the looking glass.
John Cage, in reference to his 1939 Imagined Landscape [1].

In the last installment (see here, here and here) I argued that the increasing prominence and frequency of futuristic aesthetics and themes of empowerment-through-technology in EDM-based mainstream music videos, as well as the increasing predominance of EDM foundations in mainstream music over the past 3 years, helps promote general awareness of emerging-technology-grounded and NBIC–driven concepts, causes and potential-crises while simultaneously presenting a sexy and self-empowering vision of technology and the future to mainstream audiences. The only reason this is mentionable in the first place is the fact that these are mainstream artists and labels reaching very large audiences.

In this installment, I will be analyzing a number of music videos for tracks by “real EDM” artists, released by exclusively-EDM record labels, to show that these futuristic themes aren’t just a consequence of EDM’s adoption by mainstream music over the past few years, and that there is long history of futuristic aesthetics and gestalts in electronic music, as well as recurrent themes of self-empowerment through technology.

In this part I will discuss some of these recurrent themes, which can be seen to derive from a number of aspects shared by Virtual Art (any art created without the use of physical instruments), of which contemporary electronic music is an example because it is created using software. I argue that this will become the predominant means of art production — via software — for all artistic mediums, from auditory to visual to eventual olfactory, somatosensory and proprioceptual artistic mediums. The interface between artist and art will become progressively thinner and more transparent, culminating in a time where Brain-Computer-Interface technology can sense neural operation and translate this directly into an informational form to be played by physical systems (e.g. speakers) at first, but eventually into a form that can be read by given person’s own BCI instantiated phenomenologically via high-precision technological neuromodulation (of which deep brain stimulation is an early form).

Continue reading “Electronic Music as Emerging Tech. Embryo of Art's Entire Future — Part One” »

This essay is in response to the Debate Forum “Will ‘meatbag’ bodies ever be immortal? Is ‘cyborgification’ the only logical path?”, hosted by ImmortalLife.info

In it, I explore the distinction between therapies for Longer Life (life-extension) and therapies for Unlimited Life (indefinite longevity).

If we’re talking far-future, non-biological approaches to life-extension will win out over biological approaches, due mainly to their comparative advantages (e.g. ease of repair and modification — both of which become methodological problems now rather than technological or “physical” problems so to speak, requiring a reorganization or rewriting of information — thus methodological — rather than a means of figuring out what changes to implement and then devising a technology and technique for actually implementing such changes in physicality) and because they will offer experiential and functional modalities categorically unavailable to biological systems (merely due to the fact that such functional and/or experiential modalities are determined by the structural and operational/procedural modalities of the system, and there are a much larger quantity of potential structures and operational/procedural modalities possible using non-biological systems than are available to what are normatively considered biological systems — that is, based upon cellular units forming emergent tissues, and embodying the structural and operational/procedural modalities of biological systems). That being said, I think that the distinction between non-biological and biological systems (especially if Drexlerian nanotech – that is, using mechanosynthesis – is implemented with any ubiquity) will increasingly dissolve. If a system exhibits the structural, functional and operational modalities of a biological cell, tissue, organ or organism, yet consists of wholly inorganic materials, is it not closer to a biological system than to what we would typically consider a non-biological system? Either the distinction between the two will eventually dissolve, or we will use the term “biological” to designate systems exhibiting the structural, functional, and/or operational modalities of biological systems, rather than designating systems made of specific types of material, such as organic or inorganic molecular substrate.

In the 9th installment of my 10-part introductory essay written for Transhumanity’s Certificate in Transhumanism Studies Program, I make a distinction between life-extension therapies and indefinite-longevity therapies, and I’d like to elaborate more on this distinction here. Life-extension therapies extend longevity, but for various reasons fail to make it necessarily indefinite or unlimited. Often this is because such therapies aren’t comprehensive – a given therapy solves one contributing factor of aging, but not all of them. Others, like SENS (which I’m in no way discounting), fix the major causes of damage, but use a different methodology for each respective source of damage or aging; the drawback of this approach is that if previously overshadowed causes of aging now begin to make a non-negligible impact on aging, in the absence of the more predominant causes, then we have no methodology to combat it. Because each strategy is tied intimately to the cause it seeks to ameliorate, the techniques often cannot be applied to the new source of molecular damage.

Continue reading “Longer Life or Unlimited Life?” »

1. Thou shalt first guard the Earth and preserve humanity.

Impact deflection and survival colonies hold the moral high ground above all other calls on public funds.

2. Thou shalt go into space with heavy lift rockets with hydrogen upper stages and not go extinct.

Continue reading “Ten Commandments of Space” »

The Brain Games Begin
Europe’s billion-Euro science-neuro Human Brain Project, mentioned here amongst machine morality last week, is basically already funded and well underway. Now the colonies over in the new world are getting hip, and they too have in the works a project to map/simulate/make their very own copy of the universe’s greatest known computational artifact: the gelatinous wad of convoluted electrical pudding in your skull.

The (speculated but not yet public) Brain Activity Map of America
About 300 different news sources are reporting that a Brain Activity Map project is outlined in the current administration’s to-be-presented budget, and will be detailed sometime in March. Hoards of journalists are calling it “Obama’s Brain Project,” which is stoopid, and probably only because some guy at the New Yorker did and they all decided that’s what they had to do, too. Or somesuch lameness. Or laziness? Deference? SEO?

For reasons both economic and nationalistic, America could definitely use an inspirational, large-scale scientific project right about now. Because seriously, aside from going full-Pavlov over the next iPhone, what do we really have to look forward to these days? Now, if some technotards or bible pounders monkeywrench the deal, the U.S. is going to continue that slide toward scientific… lesserness. So, hippies, religious nuts, and all you little sociopathic babies in politics: zip it. Perhaps, however, we should gently poke and prod the hard of thinking toward a marginally heightened Europhobia — that way they’ll support the project. And it’s worth it. Just, you know, for science.

Going Big. Not Huge, But Big. But Could be Massive.
Both the Euro and American flavors are no Manhattan Project-scale undertaking, in the sense of urgency and motivational factors, but more like the Human Genome Project. Still, with clear directives and similar funding levels (€1 billion Euros & $1–3 billion US bucks, respectively), they’re quite ambitious and potentially far more world changing than a big bomb. Like, seriously, man. Because brains build bombs. But hopefully an artificial brain would not. Spaceships would be nice, though.

Continue reading “Human Brain Mapping & Simulation Projects: America Wants Some, Too?” »

A response to McClelland and Plaut’s
comments in the Phys.org story:

Do brain cells need to be connected to have meaning?

Asim Roy
Department of Information Systems
Arizona State University
Tempe, Arizona, USA
www.lifeboat.com/ex/bios.asim.roy

Article reference:

Roy A. (2012). “A theory of the brain: localist representation is used widely in the brain.” Front. Psychology 3:551. doi: 10.3389/fpsyg.2012.00551

Continue reading “Response to Plaut and McClelland in the Phys.org story” »

I have been corresponding with John Hunt and have decided that perhaps it is time to start moving toward forming a group that can accomplish something.

The recent death of Neil Armstrong has people thinking about space. The explosion of a meteor over Britain and the curiosity rover on Mars are also in the news. But there is really nothing new under the sun. There is nothing that will hold people’s attention for very long outside of their own immediate comfort and basic needs. Money is the central idea of our civilization and everything else is soon forgotten. But this idea of money as the center of all activity is a death sentence. Human beings die and species eventually become extinct just as worlds and suns also are destroyed or burn out. Each of us is in the position of a circus freak on death row. Bizarre, self centered, doomed; a cosmic joke. Of all the creatures on this planet, we are the freaks the other creatures would come to mock– if they were like us. If they were supposedly intelligent like us. But are we actually the intelligent ones? The argument can be made that we lack a necessary characteristic to be considered truly intelligent life forms.

Truly intelligent creatures would be struggling with three problems if they found themselves in our situation as human beings on Earth in the first decades of this 21st century;

1. Mortality. With technology possible to delay death and eventually reverse the aging process, intelligent beings would be directing the balance of planetary resources towards conquering “natural” death.

Continue reading “The Truth about Space Travel is Stranger than Fiction” »

Whether via spintronics or some quantum breakthrough, artificial intelligence and the bizarre idea of intellects far greater than ours will soon have to be faced.
http://www.sciencedaily.com/releases/2012/08/120819153743.htm