Lifeboat Foundation

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Continue reading “Intimations of Imitations: Visions of Cellular Prosthesis & Functionally-Restorative Medicine” »

This essay was also published by the Institute for Ethics & Emerging Technologies and by Transhumanity under the title “Is Price Performance the Wrong Measure for a Coming Intelligence Explosion?”.

Introduction

Most thinkers speculating on the coming of an intelligence explosion (whether via Artificial-General-Intelligence or Whole-Brain-Emulation/uploading), such as Ray Kurzweil [1] and Hans Moravec [2], typically use computational price performance as the best measure for an impending intelligence explosion (e.g. Kurzweil’s measure is when enough processing power to satisfy his estimates for basic processing power required to simulate the human brain costs $1,000). However, I think a lurking assumption lies here: that it won’t be much of an explosion unless available to the average person. I present a scenario below that may indicate that the imminence of a coming intelligence-explosion is more impacted by basic processing speed – or instructions per second (ISP), regardless of cost or resource requirements per unit of computation, than it is by computational price performance. This scenario also yields some additional, counter-intuitive conclusions, such as that it may be easier (for a given amount of “effort” or funding) to implement WBE+AGI than it would be to implement AGI alone – or rather that using WBE as a mediator of an increase in the rate of progress in AGI may yield an AGI faster or more efficiently per unit of effort or funding than it would be to implement AGI directly.

Loaded Uploads:

Continue reading “How Could WBE+AGI be Easier than AGI Alone?” »

There is a real power in the act of physically moving. In so doing, each and every morning I can escape the cacophonous curse of the ubiquitous ESPN in the gym locker room. I toss my bag in my locker and immediately escape to the pure, perfect, custom designed peace of my iPod’s audio world. I also well remember the glorious day I moved away from the hopelessness of my roommate’s awful sub-human, sub-slum stench and into my own private apartment. The universe changed miraculously overnight. I think you can get my drift. The simple act of moving itself can be powerfully transformational. Sometimes, there is not enough bleach and not enough distance between the walls to have the desired effect. Physically moving is quite often the only answer.

As we consider transhumanist societies, such transitional power is certainly the result by many magnitudes. My team has been engaged in developing the first permanent human undersea settlement over the past few decades. In this process we have had the distinct advantage of planning profoundly transhumanist advances specifically because of the advantageous context of relative community isolation. Further we have the benefit of deriving change as a community necessity — as a psychological and cultural imperative for this degree of advanced cultural evolution. It is a real kind of powerfully driven societal punctuated equilibrium that can be realized in few other ways.

In moving into the oceans, the submarine environment itself immediately establishes the boundary between the new, evolving culture and the old. While the effect and actual meaning of this boundary is almost always overrated, it is nonetheless a real boundary layer that allows the new culture to flourish sans the interferences or contamination from the old. Trying to accomplish transhumanist goals while culturally embedded is far more difficult and far less persuasive to those who must undergo dramatic change and for the transformation to actually take hold and survive generationally. But in a new, rather isolated environment, the pressure to evolve and integrate permanent change is not only easier, it is rather expected as a part of the reasonable process of establishment.

Continue reading “The Power of the Move Outbound” »

Congratulations Drs. Musha, Pinheiro & Valone on their soon to be published new book.

For those who are interested T. Musha, M.J. Pinheiro and T. Valone (Advanced Science Technology Research Organization, Yokohama, Japan, and others) have a new book that will be published soon:

The Rocky Mountain chapter of the American Institute of Astronautics & Aeronautics (AIAA) will be having their 2^nd Annual Technical Symposium, October 25 2013. The call for papers ends May 31 2013. I would recommend submitting your papers. This conference gives you the opportunity to put your work together in a cohesive manner, get feedback and keep your copyrights, before you write your final papers for journals you will submitting to. A great way to polish your papers.

Here is the link to the call for papers: http://www.iseti.us/pdf/RMAIAA_Call_For_Abstracts_2013-0507.pdf

Here is the link to the conference: http://www.iseti.us/pdf/RMAIAA_General_Advert_2013-0507.pdf

I’ll be presenting 2 papers. The first is a slightly revised version of the presentation I gave at the APS April 2013 conference here in Denver (http://www.iseti.us/WhitePapers/APS2013/Solomon-APS-April(2013-04-15).pdf). The second is titled ‘The Mechanics of Gravity Modification’.

Continue reading “Mechanics of Gravity Modification” »

I had a great time at APS 2013 held April 13 — 16, 2013. I presented my paper “Empirical Evidence Suggest A Different Gravitational Theory” in track T10, Tuesday afternoon. A copy of the slides is available at this link.

http://www.iseti.us/WhitePapers/APS2013/Solomon-APS-April(2013-04-15).pdf

Have fun.

——————————————

Continue reading “Need for a New Theory on Gravity” »

The APS April Meeting 2013, Vol. 58 #4 will be held Saturday–Tuesday, April 13–16, 2013; Denver, Colorado.

I am very pleased to announce that my abstract was accepted and I will be presenting “Empirical Evidence Suggest A Need For A Different Gravitational Theory” at this prestigious conference.

For those of you who can make it to Denver, April 13–16, and are interested in alternative gravitational theories, lets meet up.

I am especially interested in physicists and engineers who have the funding to test gravity modification technologies, proposed in my book An Introduction to Gravity Modification.

Continue reading “American Physical Society (APS) Conference in Denver” »

Fukushima’s Second Anniversary…
Two years ago the international robot dorkosphere was stunned when, in the aftermath of the Tohoku Earthquake and Tsunami Disaster, there were no domestically produced robots in Japan ready to jump into the death-to-all-mammals radiation contamination situation at the down-melting Fukushima Daiichi nuclear power plant.

…and Japan is Hard at Work.
Suffice it to say, when Japan finds out its robots aren’t good enough — JAPAN RESPONDS! For more on how Japan has and is addressing the situation, have a jump on over to AkihabaraNews.com.

Oh, and here’s some awesome stuff sourced from the TheRobotReport.com:

Larger Image - PDF With Links

1. Thou shalt first guard the Earth and preserve humanity.

Impact deflection and survival colonies hold the moral high ground above all other calls on public funds.

2. Thou shalt go into space with heavy lift rockets with hydrogen upper stages and not go extinct.

Continue reading “Ten Commandments of Space” »