MIT and Harvard scientists have created engineered CAR-NK cells that can hide from the immune system and more effectively destroy cancer.
The cells are designed to suppress immune-rejection signals and enhance tumor-killing power. Tested in humanized mice, they wiped out cancer while avoiding dangerous immune reactions.
A major breakthrough in immune engineering.
One of the newest weapons that scientists have developed against cancer is a type of engineered immune cell known as CAR-NK (natural killer) cells. Similar to CAR-T cells, these cells can be programmed to attack cancer cells.
MIT and Harvard Medical School researchers have now come up with a new way to engineer CAR-NK cells that makes them much less likely to be rejected by the patient’s immune system, which is a common drawback of this type of treatment.
The new advance may also make it easier to develop “off-the-shelf” CAR-NK cells that could be given to patients as soon as they are diagnosed. Traditional approaches to engineering CAR-NK or CAR-T cells usually take several weeks.
A new one‑step, water‑, acid‑, and alkali‑free method for extracting high‑purity lithium from spodumene ore has the potential to transform critical metal processing and enhance renewable energy supply chains. The study is published in Science Advances.
As the demand for lithium continues to rise, particularly for use in electric cars, smartphones and power storage, current extraction methods are struggling to keep pace. Extracting lithium from salty water is a lengthy process, and traditional methods that use heat and chemicals to extract lithium from rock produce significant amounts of harmful waste.
Researchers led by James Tour, the T.T. and W.F. Chao Professor of Chemistry and professor of materials science and nanoengineering at Rice University, have developed a faster and cleaner method using flash Joule heating (FJH). This technique rapidly heats materials to thousands of degrees within milliseconds and works in conjunction with chlorine gas, exposing the rock to intense heat and chlorine gas, they can quickly convert spodumene ore into usable lithium.
Electron microscopy is an exceptional tool for peering deep into the structure of isolated molecules. But when it comes to imaging thicker biological samples to understand how those molecules function in their cellular environments, the technology gets a little murky.
Cornell researchers devised a new method, called tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM), to image thick samples with higher contrast and a fivefold increase in efficiency.
The Sept. 23 publication of the findings, in Nature Methods, arrives two years after the death of co-author Lena Kourkoutis, M.S. ‘06, Ph.D. ‘09, associate professor in applied and engineering physics in Cornell Engineering, whose work in cryo-electron microscopy drove much of the nearly 10-year effort.
In nature, random fiber networks such as some of the tissues in the human body, are strong and tough with the ability to hold together but also stretch a lot before they fail. Studying this structural randomness—that nature seems to replicate so effortlessly—is extremely difficult in the lab and is even more difficult to accurately reproduce in engineering applications.
Recently, researchers at The Grainger College of Engineering, University of Illinois Urbana-Champaign and the Rensselaer Polytechnic Institute devised a method to repeatedly print random polymer nanofiber networks with desired characteristics and use computer simulations to tune the random network characteristics for improved strength and toughness.
“This is a big leap in understanding how nanofiber networks behave,” said Ioannis Chasiotis, a professor in the Department of Aerospace Engineering. “Now, for the first time, we can reproduce randomness with desirable underlying structural parameters in the lab, and with the companion computer model, we can optimize the network structure to find the network parameters, such as nanofiber density, that produce simultaneously higher network strength, stiffness and toughness.”
A supercritical fluid refers to a state in which the temperature and pressure of a substance exceed its critical point, where no distinction exists between liquid and gas phases. Traditionally, it has been regarded as a single, uniform phase. However, a research team at POSTECH (Pohang University of Science and Technology) experimentally demonstrated nonequilibrium phase separation within supercritical fluids by observing nanometer-sized “liquid clusters” that persist for up to one hour.
The research team led by Professor Gunsu Yun from the Division of Advanced Nuclear Engineering and the Department of Physics at POSTECH, in collaboration with Dr. Jong Dae Jang’s group at the Korea Atomic Energy Research Institute (KAERI), Professor Min Young Ha at Kyung Hee University, and Dr. Changwoo Do’s team at Oak Ridge National Laboratory (ORNL) in the U.S., experimentally verified the existence of nano-clusters that exist separately in a liquid-like state within supercritical fluids previously considered a uniform phases.
The experiment utilized the Small-Angle Neutron Scattering (SANS) instrument at Korea’s neutron research facility, HANARO.
What if the next battery you buy was made from the same kinds of ingredients found in your body? That’s the idea behind a breakthrough battery material made from natural, biodegradable components. It’s so natural, it could even be consumed as food.
A team of researchers at Texas A&M University, including Distinguished Professor of Chemistry Dr. Karen Wooley and Professor of Chemical Engineering Dr. Jodie Lutkenhaus, has developed a biodegradable battery using natural polymers. The findings are published in the Proceedings of the National Academy of Sciences.
Wooley’s research group in the College of Arts and Sciences has spent the past 15 years shifting toward natural products for the construction of sustainable and degradable plastics materials. Lutkenhaus, associate dean for research in the College of Engineering, has been using organic materials to design a better battery. She suggested collaboration to combine Wooley’s naturally sourced polymers with her battery expertise.
Zap Energy has advanced its Century fusion engineering test platform to operate for more than one hundred plasma shots at 0.2 Hz, or one shot every five seconds, with the resulting heat captured by surfaces coated with circulating liquid metal.
Concentrated inside a vacuum chamber about the size of a hot water heater, each plasma carried up to 500 kA of current—about 20 times stronger than a bolt of lightning—discharged into a vessel lined with flowing liquid bismuth. During the record run, Century’s total input power was 57 kilowatts, with 39 kilowatts delivered directly to the cables leading to the plasma chamber.
Compared with Century’s commissioning milestone in 2024, this achievement represents an increase of 20 times in sustained average power and is a major step toward developing commercial fusion power plants using repetitive pulsed power and liquid metal energy transfer.
High-grade gliomas are aggressive brain tumors with poor prognosis, largely because even after surgical removal, infiltrative residual tumor cells often regrow during the latency before radiotherapy, leading to recurrence. The standard chemoradiotherapy only modestly improves survival. A crucial window of vulnerability arises post-surgery, before radiotherapy begins, where residual tumor cells are not well addressed by systemic chemotherapy.
Prof. Feng-Huei Lin and Dr. Jason Lin from National Taiwan University have designed a local post-surgical gel packing with sequential delivery of platinum agents that could maintain therapeutic drug concentrations intracranially and synergize with subsequent radiotherapy to eliminate glioma tissue. Their study is published in the Chemical Engineering Journal.
The cutting-edge drug-delivery gel can be directly injected into the surgical cavity following tumor resection. This gel provides sustained local delivery of platinum-based anticancer agents, ensuring effective eradication for residual glioma tissue that remain after surgery. The gel is designed to maximize the therapeutic impact while minimizing systemic exposure.
Cultured neural tissues have been widely used as a simplified experimental model for brain research. However, existing devices for growing and recording neural tissues, which are manufactured using semiconductor processes, have limitations in terms of shape modification and the implementation of three-dimensional (3D) structures.
By thinking outside the box, a KAIST research team has successfully created a customized 3D neural chip. They first used a 3D printer to fabricate a hollow channel structure, then used capillary action to automatically fill the channels with conductive ink, creating the electrodes and wiring. This achievement is expected to significantly increase the design freedom and versatility of brain science and brain engineering research platforms. The paper is published in the journal Advanced Functional Materials.
A research team led by Professor Yoonkey Nam from the Department of Bio and Brain Engineering has successfully developed a platform technology that overcomes the limitations of traditional semiconductor-based manufacturing. This technology allows for the precise fabrication of a 3D microelectrode array (neural interfaces with multiple microelectrodes arranged in a 3D space to measure and stimulate the electrophysiological signal of neurons) in various customized forms for in vitro culture chips.