When a person goes into deep sleep, waterlike fluid circulates around the brain, washing away metabolic waste that is linked to diseases such as Alzheimer’s. This process, known as the glymphatic system, was first described in 2012 by Maiken Nedergaard, a pioneering neuroscientist and co-director of the University of Rochester Center for Translational Neuromedicine.
But questions remain about the system’s mechanics—notably, how quickly the fluid circulates around the brain. Studying the circulation within a living brain is difficult to do without causing irreparable harm to a subject.
“You can put a microscope on a small patch of the brain and watch what’s happening there with a lot of detail, and we’ve worked with that type of data in the past, but it’s only a tiny view of the overall process,” says Professor Douglas Kelley from the University of Rochester’s Department of Mechanical Engineering.
Investigating how aging predisposes individuals to a higher metastatic risk, the authors identify that extracellular vesicles secreted by senescent hepatocytes carry miRNAs that enhance metastatic potential in tumor-bearing aged mice, with relevance for older adults with cancer.
Wang et al. profile mitochondrial RNA across 47 human tissues from 838 individuals, observing that mitochondria keep two different aging clocks: proliferative tissues accumulate many random mutations, whereas nondividing tissues progressively acquire recurrent hotspot mutations.
Investigadores enseñan a las células cerebrales a jugar a ‘Doom’
Australian researchers have trained lab-grown brain cells on a silicon computer chip to play the nineties shooter game “Doom” and say they are just scratching the surface of what the neurons could be capable of doing.
It’s the science-fiction work of biotech boffins at Cortical Labs, who researched and developed the technology that harnesses the workings of the brain’s networking system.
Each so-called “biological computer” contains around 200,000 living human brain cells, grown from stem cells that were harvested from blood donations.
The fractures aren’t in our biology. They’re in our agreements, our economic systems, and our willingness to extend the definition of “us” to include the health minister in a lower-middle-income country holding a terrifying lab result and staring at a phone they are afraid to pick up.
A study that followed more than 4,400 patients aged 40 and over found chemotherapy had ‘little or no additional benefit’ to people whose tumours had a low Prosigna test score.
In this exciting episode, we dive deep into the world of bio-inspired robotics with Prof. Auke Jan Ijspeert, a Swiss-Dutch roboticist and neuroscientist at the École Polytechnique Fédérale de Lausanne (EPFL). As the head of the Biorobotics Laboratory, Prof. Ijspeert shares how nature serves as the ultimate blueprint for designing the robots of the future. 🌿🤖
🔑 Key Highlights:
Bio-Inspired Robotics: Explore how Prof. Ijspeert and his team are mimicking nature to create innovative robots that move and behave like animals. Neuroscience & Robotics: Learn how insights from neuroscience help reverse-engineer the sensorimotor coordination found in animals, applying it to robotic systems. From Simulation to Reality: Discover the challenges of translating robotic simulations into real-world applications. Exoskeletons & Assistive Technologies: Prof. Ijspeert discusses the development of exoskeletons for healthcare and military use, along with assistive furniture for people with limited mobility. Humanoid Robots & Autonomous Systems: Get a sneak peek into the future of autonomous robotics, from central pattern generators to humanoid robots.
💡 Why You Should Watch: Prof. Ijspeert is a trailblazer in the field of biorobotics, blending biology, neuroscience, and engineering to push the boundaries of what robots can achieve. Whether you’re a robotics enthusiast, a neuroscientist, or just curious about how nature inspires technology, this episode is packed with insights that could shape the future of robotics and artificial intelligence.
🔗 Connect with Prof. Auke Ijspeert:
https://www.epfl.ch/labs/biorob/peopl… / biorob_epfl / biorob_epfl Time Stamp 0:00 to 02:35 — Intro, Bio-Inspired Robots 02:35 to 04:13 — Neuroscience to back engineer bio-robots 04:13 to 06:22 — Mimicking nature & biorobots examples 06:22 to 07:55 — Simulation to real life translation challenges 07:55 to 09:10 — Central pattern generators & their role in robotic motion 09:10 to 10:47 — Learnings from creating bio-inspired robots 10:47 to 13:40 — EPFL Bio-Robotics laboratory 13:40 to 15:43 — Applications of Bio-robotics 15:43 to 20:05 — Exoskeleton 18:19 to 20:05 — Assertive furniture robotics 20:05 to 26:30 — exoskeleton in healthcare & military warfare 26:30 to 31:51 — Humanoid Robots 31:51 to 34:42 — Autonomous Robots 34:42 to 37:04 — Rhex Robots & Partnerships 37:04 to 40:04 — The future of robotics Watch our highest-viewed videos: 1-DR R VIJAYARAGHAVAN — PROF & PRINCIPAL INVESTIGATOR AT TIFR India’s 1st Quantum Computer– • Quantum computer from India with Dr r vija… 2-TATA MOTORS-DRIVING THE FUTURE OF MOBILITY IN INDIA-SHAILESH CHANDRA-MD: TATA MOTORS– • TATA MOTORS-DRIVING THE FUTURE OF MOBILIT… 3-MIT REPORT PREDICTS SOCIETAL COLLAPSE BY 2040 — GAYA HERRINGTON DIR SUSTAINABILITY: KPMG • MIT Report predicts Total Societal Collaps… 4-WORLDS 1ST HUMAN HEAD TRANSPLANTATION-DR SERGIO CANAVERO — • WORLDS 1ST HUMAN HEAD TRANSPLANTATION-DR… 5-DR HAROLD KATCHER — CTO NUGENICS RESEARCH Breakthrough in Age Reversal– • BREAKTHROUGH IN AGE REVERSAL WITH YOUNGBLO… 6-How Neuroscience Will Change The Future Of Technology — Dr. James Giordano • How Neuroscience Will Change The Future Of… 7-STARTUP FROM INDIA AIMING FOR LEVEL 5 AUTONOMY — SANJEEV SHARMA CEO SWAAYATT ROBOTS — • SELF-DRIVING STARTUP FROM INDIA AIMING FOR… 8-MAN BEHIND GOOGLE QUANTUM SUPREMACY — JOHN MARTINIS — • MAN BEHIND GOOGLE QUANTUM SUPREMACY — JOHN… 9-BANKING 4.0 — BRETT KING FUTURIST, BESTSELLING AUTHOR & FOUNDER MOVEN — • BANKING 4.0 — BRETT KING FUTURIST, BESTSEL… 10-E-VTOL & HYPERLOOP-FUTURE OF INDIA” S MOBILITY-SATYANARAYANA CHAKRAVARTHY • E-VTOL & HYPERLOOP-FUTURE OF INDIA“S MOBI… 11-HOW NEUROMORPHIC COMPUTING WILL ACCELERATE ARTIFICIAL INTELLIGENCE — PROF SHUBHAM SAHAY-IIT KANPUR– • HOW NEUROMORPHIC COMPUTING WILL ACCELERATE… 12-How India Is Building a Quantum Computer — Dr. Anirban Bandyopadhyay • How India Is Building a Quantum Computer -… Connect & Follow us at: / eddieavil / change-transform-india / changetransformindia / intothechange / changetransformindia Listen to the Audio Podcast at: https://anchor.fm/transform-impossiblehttps://podcasts.apple.com/us/podcast… https://open.spotify.com/show/56IZXdz… https://www.breaker.audio/change-i-m–… https://www.google.com/podcasts?feed=… Don’t Forget to Subscribe / @toctwpodcast #robot #robotics #artificialintelligence #epfl.
This review examines the clinical utility of circulating tumor DNA assays for detecting minimal residual disease in patients with early-stage breast cancer.
Those who received a high score (above 60) were given chemotherapy and hormone therapy, while those with a low score (less than or equal to 60) were treated with hormone therapy alone.
Of the low-scoring group who did not receive chemotherapy, results showed that outcomes were very similar whether chemotherapy was given or not. Five years after treatment, 94.8 per cent of those who received chemotherapy alongside hormone therapy were alive and free from breast cancer recurrence, and 93.6 per cent of those treated with hormone therapy alone were also alive and recurrence-free.
Doctors said the results show that people aged 40 or older with hormone‑sensitive breast cancer and a low Prosigna score can safely avoid chemotherapy.
