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Category: biotech/medical

Senescent neutrophils: a hidden role in cancer progression

Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body of literature has shown that tumor-associated neutrophils (TANs) acquire a prolonged lifespan. This review discusses recent work surrounding the mechanisms by which neutrophils can persist in the tumor microenvironment (TME). It also highlights different scenarios for therapeutic targeting of protumorigenic neutrophils, supporting the idea that, in tumors, inhibition of neutrophil recruitment is not sufficient because these cells can persist and remain hidden from current interventions. Hence, the elimination of long-lived neutrophils should be pursued to increase the efficacy of standard therapy.

New multiple sclerosis criteria could reveal disease before symptoms appear

The international guidelines for diagnosing multiple sclerosis (MS), called the McDonald criteria, underwent their most significant overhaul in a decade in 2024. The internationally recognized framework is used to diagnose MS by combining clinical, imaging and laboratory findings. Dr. Jiwon Oh, director of the BARLO MS Centre at St. Michael’s Hospital, was among the experts who helped write them.

Now, in a commentary published in Nature Medicine, Oh has brought together nearly 30 of the world’s leading MS clinicians to critically evaluate what those changes mean and where the field must go next to improve health outcomes for people with MS. Many of its co-authors also helped develop the revised criteria in 2024.

“This commentary looks critically at the new criteria and explains why these changes matter, what challenges may arise as they’re used, and what can be done to address them,” explains Oh. “It also takes a broader look at where the field needs to go next.”

AI tool improves DNA-DNA predictions

Researchers have demonstrated a novel AI model that can predict which DNA molecules bind with which other DNA molecules. Providing a more thorough understanding of these hypercomplex binding relationships has utility in applications ranging from biomedical diagnostic tools to DNA computing.

“We often think about binding as a very simple relationship – Molecule A binds to Molecule B,” says the co-corresponding author of the study. “But in biological systems, it’s far from simple. Molecule A may bind to dozens of other molecules, to varying degrees.

Capturing that hypercomplexity is a significant challenge, but it is critical if we want to better understand natural genetic systems, says the author. And capturing that hypercomplexity is also critical if we want to develop tools that make full use of biomolecules, such as diagnostic tools that are sensitive to genetic differences or DNA computing systems that rely on DNA to store and retrieve data.

New model improves short- and long-term disease risk prediction

Researchers developed ALADYNOULLI, a Bayesian generative model that combines longitudinal health records, age, and polygenic risk to identify reproducible disease signatures across more than 683,000 participants. In UK Biobank testing, the framework achieved stronger short- and long-term risk discrimination than established clinical scores while revealing disease subgroups and genetic associations.

This sugar-coated therapy boosted survival against deadly brain cancer by 50% in mice

A new experimental treatment may have found a way to outsmart glioblastoma’s toughest defense: the blood-brain barrier. Researchers used sugar-coated nanoparticles to ferry genetic instructions that restore a key tumor-suppressing protein directly into brain cancer cells. In mouse studies, the therapy increased median survival by 50% while shrinking tumors without noticeable damage to other organs.

Engineers shrink powerful terahertz systems onto a single semiconductor chip

High-frequency waves classified as terahertz occupy a relatively underused region of the electromagnetic spectrum between infrared light and microwaves. Researchers have long recognized their unique potential for applications including ultrafast wireless communication, security screening, remote sensing and medical imaging.

As technologies push toward higher operating frequencies and data rates, photonics-based terahertz systems, which use light at high speed to generate and process terahertz signals, have emerged as a promising alternative to conventional electronic technologies because of their superior bandwidth and power efficiency. However, today’s terahertz optoelectronic systems, which are electronic systems that control light, remain bulky, complex and difficult to scale for widespread use. They typically rely on multiple separate components—including lasers, amplifiers, modulators, sources and detectors—that must be individually made, aligned and interconnected, limiting their use outside specialized laboratory settings.

Now, a UCLA–led research team has demonstrated a way to integrate these functions onto a single semiconductor chip compatible with modern photonic technologies. The breakthrough, published in Nature Communications, paves the way for compact, scalable terahertz systems for next-generation communication, imaging and sensing applications.

New computational imaging method cuts X-ray dose while preserving high resolution

Researchers have shown that it’s possible to take clear, high-resolution X-ray images using very little radiation. With more development, the new approach could eventually make medical X-ray diagnostics less risky and more accessible.

“While traditional X-ray imaging relies on enough X-ray photons reaching a detector to form a clear image, our approach uses computational techniques to reconstruct an image from fewer photons,” said research team leader Tiqiao Xiao from the Shanghai Advanced Research Institute, Chinese Academy of Sciences. “We were able to show the low-dose potential of this approach by achieving megapixel radiology with ultra-low-light.”

In Optica, the researchers demonstrate X-ray ghost images with nearly 2-megapixel resolution using only 0.48% of the X-ray photons typically required for X-ray imaging. The proof-of-concept study suggests that comparable X-ray image quality may eventually be achievable with far lower radiation doses than are used today.

CSF Testing for Neuroinvasive West Nile Virus and Measures to Improve Guideline Adherence

Background and ObjectivesDiagnosis of West Nile virus (WNV) neuroinvasive disease, an important cause of neurologic disability in endemic areas, requires appropriate testing given its often nonspecific presentation. Guidelines recommend CSF testing of WNV-…

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