Systolic blood pressure trajectory and outcomes in acute intracerebral hemorrhage: pooled analysis of the 4 INTERACT and ATACH-II clinical trials.
Background and Objectives.
Category: biotech/medical
Abstract: Immune signaling and function in neurodegeneration:
Yvonne L. Latour & Dorian B. McGavern contribute a Review to the JCI Series on Neurodegeneration, discussing signaling pathways, cellular players, and immune responses shared across multiple neurodegenerative diseases, while considering external factors that may influence CNS disease progression. Neurodegeneration.
Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Intranasal Human NSC‐Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS‐STING Signalling, in Aged Hippocampus
Tiny “fires” of inflammation smolder deep within the brain’s memory center, creating a persistent brain fog that makes it harder to think, form new memories or even adapt to new environments, all the while increasing the risk to disorders like Alzheimer’s disease.
Scientists call this slow burn “neuroinflammaging,” and for decades it was thought to be the inevitable price of growing older.
Until now.
A landmark study from researchers at the Texas A&M University Naresh K. Vashisht College of Medicine suggests the inflammatory tide responsible for brain aging and brain fog might actually be reversible. And the solution doesn’t involve brain surgery, but a simple nasal spray.
Led by Dr. Ashok Shetty, university distinguished professor and associate director of the Institute for Regenerative Medicine, along with senior research scientists Dr. Madhu Leelavathi Narayana and Dr. Maheedhar Kodali, the team developed a nasal spray that, with just two doses, dramatically reduced brain inflammation, restored the brain’s cellular power plants and significantly improved memory.
The most surprising part? It all happened within weeks and lasted for months.
The findings, published in the Journal of Extracellular Vesicles, could reshape the future of neurodegenerative therapies and may even change how scientists think about brain aging itself.
Scientists Just Took A Major Step Towards One Of Sci-Fi’s Biggest Tropes
Major milestone in the viability of cryonic suspension in the form of revival of cells after vitrification. Vitrification is basically the use of chemical fixation at ultra cold temperatures, kinda like antifreeze. It prevents ice crystals forming in your cells, preventing them from being torn apart.
It’s INSANELY toxic, so solving that problem would mean we can really revive people in suspension who underwent vitrification (which is standard practice at ALCOR for a long time now).
That said, we still will need ways to repair whatever disease or injury that the patient actually died from. 😁👍
Researchers in Germany have developed a technique to vitrify mouse brain tissue and then thaw it out, all without significant loss of function.
Human Gene Editing Has Begun | George Church
We are already gene editing humans. You just haven’t noticed.
George Church, Harvard geneticist and Human Genome Project pioneer, explains why CRISPR wasn’t the real breakthrough, how multiplex gene editing unlocked organ transplants and de-extinction, and why aging will likely require rewriting many genes at once.
Hosted by Mgoes → https://twitter.com/m_goes_distance
Brought to you by SuperHuman Fund → https://superhuman.fund/
0:00 — Gene Editing Mammals → Humans
8:36 — Germline vs Somatic
14:56 — Modified Humans Are Already Here
18:50 — Enhancing Healthy Humans
25:00 — Aging Therapies vs Cognitive Enhancement
30:20 — Embryo Selection
38:10 — Is US Losing To UAE?
42:33 — Biotech Failures
49:31 — Next Dire Wolf Moment
54:21 — AI x Science
1:02:07 — Synthetizing Entire Genomes.
The Accelerate Bio Podcast explores the future of humanity in the age of Artificial Intelligence. Subscribe for deep-dive conversations with founders, scientists, and investors shaping AI, biotechnology, and human progress.
This episode discusses George Church, gene editing, CRISPR, human enhancement, longevity, aging, embryo selection, synthetic biology, multiplex editing, AI biotech.
Genetic atlas reveals how human liver cells divide their labor
If scientists could shrink themselves to microscopic size and take a journey through the human body—like the submarine crew in the 1966 science fiction classic “Fantastic Voyage”—one of their first stops would no doubt be the liver. The unique structure of our largest internal organ comprises small, hexagonal functional units called lobules, each carrying out more than 500 functions simultaneously. Studies from the 1970s and 1980s revealed that liver cells divide these many tasks among themselves according to their location within each subunit; however, the technology available at the time provided only a blurred picture of this division of labor.
In a new study published in Nature, scientists from the Weizmann Institute of Science, together with colleagues at Sheba Medical Center and the Mayo Clinic, present the first genetic atlas of a healthy human liver at a resolution of 2 microns. The findings show that the division of labor in the human liver differs from that of other mammals and is more extensive than previously recognized, helping explain why certain regions of the liver are particularly vulnerable to fatty liver disease.
In recent years, technological advances have made it possible to identify which genes are active in each individual cell while also mapping the cells’ precise spatial positions within the tissue. Still, a comprehensive map of functional division in the human liver remained elusive, largely due to the difficulty of obtaining tissue samples from healthy donors.
By cutting selected synapses, brain circuit ‘editing’ could make memory stronger and rewire how learning works
Every thought, memory, and feeling we experience depends on trillions of tiny connection points in the brain called synapses. These are the junctions where one neuron passes signals to another, forming the vast communication network known as the connectome—the brain’s wiring diagram. Although scientists have developed powerful tools to increase or decrease neural activity, directly redesigning the brain’s physical wiring has remained far more difficult.
A research team led by Dr. Sangkyu Lee and Director C. Justin Lee at the Center for Memory and Glioscience within the Institute for Basic Science (IBS), in collaboration with Dr. Kea Joo Lee of the Korea Brain Research Institute (KBRI), has now developed a molecular tool that makes such structural editing possible. The new platform, called SynTrogo (Synthetic Trogocytosis), enables researchers to induce astrocytes to selectively remodel synaptic connections in a targeted brain circuit. The paper is published in the journal Nature Communications.
The brain already has a natural mechanism for refining its wiring. During development and throughout life, unneeded or weak connections are removed in a process known as synaptic pruning, much like trimming unnecessary branches from a tree. This pruning is partly carried out by astrocytes—star-shaped glial cells that closely surround synapses and help maintain the neural environment. When this process becomes dysregulated, either through too much or too little pruning, it has been linked to disorders such as schizophrenia, autism spectrum disorder, and Alzheimer’s disease.
Implantable islet cells could control diabetes without insulin injections
Most diabetes patients must carefully monitor their blood sugar levels and inject insulin multiple times per day, to help keep their blood sugar from getting too high. As a possible alternative to those injections, MIT researchers are developing an implantable device that contains insulin-producing cells. The device encapsulates the cells, protecting them from immune rejection, and it also carries an onboard oxygen generator to keep the cells healthy.
This device, the researchers hope, could offer a way to achieve long-term control of type 1 diabetes. In a new study, they showed that these encapsulated pancreatic islet cells could survive in the body for at least 90 days. In mice that received the implants, the cells remained functional and produced enough insulin to control the animals’ blood sugar levels.
“Islet cell therapy can be a transformative treatment for patients. However, current methods also require immune suppression, which for some people can be really debilitating,” says Daniel Anderson, a professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science. “Our goal is to find a way to give patients the benefit of cell therapy without the need for immune suppression.”
Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells
Although radioresistant and circulating tumor cell survival has been attributed to altered metabolism, the metabolic impact of radiation therapy on stromal cells is unknown. Corn et al. demonstrate radiation-induced mitochondrial and metabolic changes in fibroblasts that are regulated by autophagy and drive growth in triple-negative breast cancer.
Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders
The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences. Key findings include specific miRNAs associated with inflammatory processes and dietary patterns. Notably, miR-155 was associated with subjects with metabolic diseases and upregulated in age. Additionally, the study revealed diet-related miRNA expressions: high consumption of vegetables, fruits, and whole grains correlated with increased levels of miR-let-7a and miR-328, both implicated in anti-inflammatory pathways, and decreased expression of pro-inflammatory miR-21.