Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: nanotechnology – Page 2

Memristors achieve stable resistance values tied to fundamental constants of nature

Researchers at Forschungszentrum Jülich, together with international collaborators, have demonstrated for the first time that memristors—novel nanoscale switching devices—can provide stable resistance values directly linked to fundamental constants of nature. This paves the way for electrical units such as electrical resistance to be traced back far more simply and directly than it has been possible to date. By contrast, conventional, quantum-based measurement technology is so demanding that it can only be carried out in a few specialized laboratories worldwide.

The paper is published in the journal Nature Nanotechnology.

Since 2019, all base units of the International System of Units (SI)—including the meter, second, and kilogram—have been based on fundamental natural constants. For example, the kilogram, which was once based on the “prototype kilogram,” is now linked to Planck’s constant h. A meter is defined by the speed of light, and a second by the oscillation of the cesium atom.

Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning

I first explored this amazing work back when it was a preprint! Wang et al. herein developed VIPS (volumetric imaging via photochemical sectioning), a way of using UV light to remove layers of expanded tissue-hydrogel, allowing combination of high-resolution lattice-light sheet microscopy with expansion microscopy. Link: [ https://www.science.org/doi/10.1126/science.adr9109]

In my opinion, this technology has enormous future promise for high-throughput connectomics! They will need to improve their labeling density so that higher expansion factors can be used, but this problem is well-studied and I think the issue will likely be solvable with additional resources/effort.

Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structures with molecular contrast. However, existing high-resolution fluorescence microscopes are physically limited by objective-to-specimen distance, which prevents the study of whole-mount specimens without physical sectioning. To address this challenge, we developed a photochemical strategy for spatially precise sectioning of specimens. By combining serial photochemical sectioning with lattice light-sheet imaging and petabyte-scale computation, we imaged and reconstructed axons and myelin sheaths across entire mouse olfactory bulbs at nanoscale resolution.

Jeremy Barton | A Path to Atomically Precise Manufacturing @ Paths to Progress

Jeremy Barton and Nanotechnology.

*This video was recorded at ‘Paths to Progress’ at LabWeek hosted by Protocol Labs & Foresight Institute.*

Protocol Labs and Foresight Institute are excited to invite you to apply to a 5-day mini workshop series to celebrate LabWeek, PL’s decentralized conference to further public goods. The theme of the series, Paths to Progress, is aimed at (re)-igniting long overdue progress in longevity bio, molecular nanotechnology, neurotechnology, crypto & AI, and space through emerging decentralized, open, and technology-enabled funding mechanisms.

*This mini-workshop is focused on Paths to Progress in Molecular Nanotechnology*
Molecular manufacturing, in its most ambitious incarnation, would use programmable tools to bring together molecules to make precisely bonded components in order to build larger structures from the ground up. This would enable general-purpose manufacturing of new materials and machines, at a fraction of current waste and price. We are currently nowhere near this ambitious goal. However, recent progress in sub-fields such as DNA nanotechnology, protein-engineering, STM, and AFM provide possible building blocks for the construction of a v1 of molecular manufacturing; the molecular 3D printer. Let’s explore the state of the art and what type of innovation mechanisms could bridge the valley of death: how might we update the original Nanotech roadmap; is a tech tree enough? how might we fund the highly interdisciplinary progress needed to succeed: FRO vs. DAO?

*About The Foresight Institute*

Continue reading “Jeremy Barton | A Path to Atomically Precise Manufacturing @ Paths to Progress” | >

How San Francisco became Waymo-pilled

Shifted from slightly against to strongly in favor. 2023: half oppose, 2025: only 29 oppose. People fear new technology… until it is no longer new.

Expect this to happen with things like cell ag (lab grown meat), nanobots, and the like. Most people are not ideologically oppose to them, they just want enough time for them to prove themselves as safe.

“Opposition to autonomous vehicles is on the decline, the poll showed: In 2023, more than 50% of voters opposed driverless cars; now, it’s 29%.”

And:

“Two-thirds of voters said they support allowing fully autonomous vehicles to operate in San Francisco. It’s a significant increase from 2023, when fewer than half agreed with the sentiment.”

(https://sfstandard.com/2025/10/08/san-francisco-became-waymo-pilled/)

Continue reading “How San Francisco became Waymo-pilled” | >

This experimental “super vaccine” stopped cancer cold in the lab

Researchers at the University of Massachusetts Amherst have shown that their nanoparticle-based vaccine can successfully prevent several aggressive cancers in mice, including melanoma, pancreatic cancer, and triple-negative breast cancer. Depending on the cancer type, up to 88% of vaccinated mice stayed tumor-free (depending on the cancer), and the vaccine also reduced — and in some cases completely prevented — the spread of cancer throughout the body.

“By engineering these nanoparticles to activate the immune system via multi-pathway activation that combines with cancer-specific antigens, we can prevent tumor growth with remarkable survival rates,” says Prabhani Atukorale, assistant professor of biomedical engineering in the Riccio College of Engineering at UMass Amherst and corresponding author on the paper.

Atukorale had previously shown that her nanoparticle-based drug design could shrink or eliminate tumors in mice. The new findings reveal that this approach can also prevent cancer from forming in the first place.

Nanoparticles supercharge vinegar’s old-fashioned wound healing power

Wounds that do not heal are often caused by bacterial infections and are particularly dangerous for the elderly and people with diabetes, cancer and other conditions. Acetic acid (more commonly known as vinegar) has been used for centuries as a disinfectant, but it is only effective against a small number of bacteria, and it does not kill the most dangerous types.

New research led by researchers at University of Bergen in Norway, QIMR Berghofer and Flinders University in Australia has resulted in the ability to boost the natural bacterial killing qualities of vinegar by adding antimicrobial nanoparticles made from carbon and cobalt. The findings have been published in the journal ACS Nano.

Molecular biologists Dr. Adam Truskewycz and Professor Nils Halberg found these particles could kill several dangerous bacterial species, and their activity was enhanced when added to a weak vinegar solution.

Scientists map dendritic cell reactions to mRNA vaccines

Belgian scientists have uncovered new details about how the immune system responds to vaccines. Dendritic cells, which are key immune messengers that help kick-start the body’s defenses, show specific responses to lipid nanoparticles. These findings, published in Cell Reports, could lead to safer and more effective vaccines.

Dendritic cells are among the first to detect viruses, bacteria, or other immune challenges. These cells help coordinate the immune system’s response by alerting T cells, the immune system’s soldiers trained to eliminate threats. But dendritic cells don’t always respond in the same way. Some keep the immune system calm and balanced (homeostatic), while others drive a full immune attack (immunogenic).

Until now, little was known about what determines these different responses, especially when dendritic cells encounter vaccines.

The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing

The rise of cell-based therapies, regenerative medicine, and synthetic biology, has created an urgent need for efficient cell engineering, which involves the manipulation of cells for specific purposes. This demand is driven by breakthroughs in cell manufacturing, from fundamental research to clinical therapies. These innovations have come with a deeper understanding of developmental biology, continued optimization of mechanobiological processes and platforms, and the deployment of advanced biotechnological approaches. Induced pluripotent stem cells and immunotherapies like chimeric antigen receptor T cells enable personalized, scalable treatments for regenerative medicine and diseases beyond oncology. But continued development of cell manufacturing and its concomitant clinical advances is hindered by limitations in the production, efficiency, safety, regulation, cost-effectiveness, and scalability of current manufacturing routes. Here, recent developments are examined in cell engineering, with particular emphasis on mechanical aspects, including biomaterial design, the use of mechanical confinement, and the application of micro-and nanotechnologies in the efficient production of enhanced cells. Emerging approaches are described along each of these avenues based on state-of-the-art fundamental mechanobiology. It is called on the field to consider mechanical cues, often overlooked in cell manufacturing, as key tools to augment or, at times, even to replace the use of traditional soluble factors.

Current manufacturing workflows for CAR-based immunotherapies, particularly CAR T, and the emerging CAR NK and CAR macrophage platforms, generally involve four key stages: (i) isolation of primary immune cells or their precursors, (ii) cell activation or differentiation, (iii) genetic modification with CAR constructs, most often via viral vectors or electroporation (EP), and (iv) expansion or preparation for reinfusion. Among these, transfection remains the most critical and technically challenging step, directly influencing the functionality, safety, and scalability of the final product.

In clinical-scale production, EP remains the most widely used non-viral method for gene delivery into immune cells, yet it is increasingly recognized as suboptimal, particularly when delivering large or complex CAR constructs. It suffers from inefficient nuclear delivery, high cell toxicity, and poor functional yields of viable, potent CAR-expressing cells.[ 113 ] These limitations are further exacerbated in more fragile or less permissive cell types, such as NK cells and macrophages, which show lower transfection efficiencies and greater sensitivity to electroporation-induced stress.[ 114 ] Viral vectors, while still dominant in clinical manufacturing, present their own challenges: they are constrained by limited cargo capacity, are costly to produce at scale, and raise regulatory and safety concerns, especially when applied to emerging CAR-NK and CAR macrophage therapies that require flexible, transient, or multiplexed genetic programs.[ 115 ]

In contrast to immune-cell engineering, stem cell-based approaches present a different set of challenges and engineering requirements. While immune cells are genetically modified to enhance cytotoxicity[ 116 ] and specificity or to mitigate excessive T-cell activation,[ 117 ] stem cells must be engineered to control self-renewal, lineage commitment, and functional integration, often requiring precise, non-integrative delivery of genetic or epigenetic modulators (e.g., mRNA, episomal vectors) to maintain cellular identity and safety.[ 118 ] Stem cells hold exceptional therapeutic promise due to their capacity for self-renewal and differentiation into specialized cell types, supporting applications in personalized disease modeling, tissue repair, and organ regeneration.[ 119 ] However, engineering stem cells in a safe, efficient, and clinically relevant manner remains a major challenge. Conventional delivery methods, such as viral vectors and EP, can compromise genomic integrity,[ 120 ] reduce viability,[ 118 ] and induce epigenetic instability,[ 121 ] limiting their translational potential.

Novel carbon nanotube-based transistors reach THz frequencies

Carbon nanotubes (CNTs), cylindrical nanostructures made of carbon atoms arranged in a hexagonal lattice, have proved to be promising for the fabrication of various electronic devices. In fact, these structures exhibit outstanding electrical conductivity and mechanical strength, both of which are highly favorable for the development of transistors (i.e., the devices that control the flow of current in electronics).

In recent years, several have started using CNTs to develop various electronics, including metal-oxide-semiconductor field-effect transistors (MOSFETs). MOSFETs are transistors that control the flow of current through a semiconducting channel utilizing an applied to a gate electrode.

Notably, when arrays of CNTs are used to develop MOSFETs, they can operate at (RF), the range of electromagnetic waves that support wireless communication. The resulting MOSFETs could thus be particularly advantageous for the advancement of wireless communication systems and technologies.

/* */