A combination of advances in magnetic resonance imaging to help track the movement of fluids in the brain and supercomputer-powered simulations are modifying our understanding of cognitive decline.
DESI Survey announces the most precise measurements of our expanding #universe using the BAO signal in 6.1 Million #galaxies and #Quasars from Year 1, tracing dark energy through cosmic time.
With 5,000 tiny robots in a mountaintop telescope, researchers can look 11 billion years into the past. The light from far-flung objects in space is just now reaching the Dark Energy Spectroscopic Instrument (DESI), enabling us to map our cosmos as it was in its youth and trace its growth to what we see today. Understanding how our universe has evolved is tied to how it ends, and to one of the biggest mysteries in physics: dark energy, the unknown ingredient causing our universe to expand faster and faster.
A generation of physicists has referred to the dark energy that permeates the universe as “the cosmological constant.” Now the largest map of the cosmos to date hints that this mysterious energy has been changing over billions of years.
Did Mars once contain life, or even the building block for life? This is what NASA’s Perseverance (Percy) rover has been trying to determine ever since it landed in Jezero Crater, which has shown an overwhelming amount of evidence to have once been site to a massive lakebed. Now, NASA recently announced that Percy has collected its 24th rock sample on March 11th, nicknamed “Comet Geyser”, with this sample being unlike the first 23 in that evidence suggests it was submerged in standing water for an indeterminant amount of time when Mars had liquid water billions of years ago.
Mosaic image of the drill holes where NASA’s Perseverance Mars rover extracted the “Comet Geyser” rock sample. (Credit: NASA/JPL-Caltech/ASU/MSSS)
“To put it simply, this is the kind of rock we had hoped to find when we decided to investigate Jezero Crater,” said Dr. Ken Farley, who is a project scientist for Perseverance and a professor of geochemistry at the California Institute of Technology. “Nearly all the minerals in the rock we just sampled were made in water; on Earth, water-deposited minerals are often good at trapping and preserving ancient organic material and biosignatures. The rock can even tell us about Mars climate conditions that were present when it was formed.”
Andrew Scott on why humanity must pursue an ‘evergreen’ agenda to become a longevity society, rather than an aging one.
Pittsburgh biotech grows second liver in-body:
As per Nature, the experimental procedure was conducted in Houston on March 25. The report also states that the patient is “recovering well” after receiving the treatment. However, the formation of the new liver-like organ in the lymph node may take several months.
Moreover, the individual will be kept on immunosuppressive drugs to prevent any initial rejection of the donor cells.
Continue reading “Groundbreaking trial to grow ‘mini liver’ from patient’s own lymph node” »
Company eyes clinical trials of mRNA therapy targeting intracellular free cholesterol after receiving ‘favorable’ pre-IND feedback.
“Gravity pulls matter together, so that when we throw a ball in the air, the Earth’s gravity pulls it down toward the planet,” Mustapha Ishak-Boushaki, a professor of physics in the School of Natural Sciences and Mathematics (NSM) at UT Dallas, and member of the DESI collaboration, said in a statement. “But at the largest scales, the universe acts differently. It’s acting like there is something repulsive pushing the universe apart and accelerating its expansion. This is a big mystery, and we are investigating it on several fronts. Is it an unknown dark energy in the universe, or is it a modification of Albert Einstein’s theory of gravity at cosmological scales?”
DESI’s data, however, shows that the universe may have evolved in a way that isn’t quite consistent with the Lambda CDM model, indicating that the effects of dark energy on the universe may have changed since the early days of the cosmos.
“Our results show some interesting deviations from the standard model of the universe that could indicate that dark energy is evolving over time,” Ishak-Boushaki said. “The more data we collect, the better equipped we will be to determine whether this finding holds. With more data, we might identify different explanations for the result we observe or confirm it. If it persists, such a result will shed some light on what is causing cosmic acceleration and provide a huge step in understanding the evolution of our universe.”
USA: Using an electronic health record (EHR)-based algorithm plus practice facilitators embedded in primary care clinics did not reduce hospitalization at one year, according to a pragmatic trial involving patients with the triad of chronic kidney disease, hypertension, and type 2 diabetes.
“The hospitalization rate of patients in the intervention group at one year was about the same as that with usual care (20.7% vs 21.1%),” the researchers reported in the ICD-Pieces study published in the New England Journal of Medicine.
Patients with chronic kidney disease (CKD), type 2 diabetes (T2D), and hypertension (the kidney-dysfunction triad) are at high risk for multiple complications, end-stage kidney disease, and premature death. Despite the availability of effective therapies for these patients, there is a lack of results of large-scale trials examining the implementation of guideline-directed therapy to reduce death and complications risk in this population.
A theory of consciousness should capture its phenomenology, characterize its ontological status and extent, explain its causal structure and genesis, and describe its function. Here, I advance the notion that consciousness is best understood as an operator, in the sense of a physically implemented transition function that is acting on a representational substrate and controls its temporal evolution, and as such has no identity as an object or thing, but (like software running on a digital computer) it can be characterized as a law. Starting from the observation that biological information processing in multicellular substrates is based on self organization, I explore the conjecture that the functionality of consciousness represents the simplest algorithm that is discoverable by such substrates, and can impose function approximation via increasing representational coherence. I describe some properties of this operator, both with the goal of recovering the phenomenology of consciousness, and to get closer to a specification that would allow recreating it in computational simulations.
