Lifeboat Foundation

Engineered vesicular stomatitis virus (VSV) pseudotyping offers an essential method for exploring virus–cell interactions, particularly for viruses that require high biosafety levels. Although this approach has been employed effectively, the current methodologies for virus visualization and labeling can interfere with infectivity and lead to misinterpretation of results. In this study, we introduce an innovative approach combining genetic code expansion (GCE) and click chemistry with pseudotyped VSV to produce highly fluorescent and infectious pseudoviruses (clickVSVs). These clickVSVs enable robust and precise virus–cell interaction studies without compromising the biological function of the viral surface proteins. We evaluated this approach by generating VSVs bearing a unique chemical handle for click labeling and assessing the infectivity in relevant cell lines.

In 1916, famed theoretical physicist Albert Einstein put the finishing touches on his Theory of General Relativity, a geometric theory for how gravity alters the curvature of spacetime. The revolutionary theory remains foundational to our models of how the Universe formed and evolved. One of the many things GR predicted was what is known as gravitational lenses, where objects with massive gravitational fields will distort and magnify light coming from more distant objects. Astronomers have used lenses to conduct deep-field observations and see farther into space.

In recent years, scientists like Claudio Maccone and Slava Turyshev have explored how using our Sun as a Solar Gravity Lens (SGL) could have tremendous applications for astronomy and the Search for Extratterstiral Intelligence (SETI). Two notable examples include studying exoplanets in extreme detail or creating an interstellar communication network (a “galactic internet”). In a recent paper, Turyshev proposes how advanced civilizations could use SGLs to transmit power from star to star – a possibility that could have significant implications in our search for technosignatures.

The preprint of Turyshev’s paper, “Gravitational lensing for interstellar power transmission,” recently appeared online and is being reviewed for publication. Slava G. Turyshev is a research scientist with the Structure of the Universe Research Group at NASA’s Jet Propulsion Laboratory. This group is engaged in a wide range of research topics associated with the evolution of the Universe from the Big Bang to the present day. This includes the formation of the first stars and galaxies, the role of Dark Matter and Dark Energy in the formation of large-scale cosmic structures, and the accelerating expansion of the cosmos Universe (respectively).

The European Space Agency (ESA) has just released the first full-color images captured by its groundbreaking Euclid space telescope. These stunning images are part of the mission’s Early Release Observations, which showcase the telescope’s ability to capture razor-sharp astronomical views across a vast expanse of the sky.

Unlike any telescope before it, Euclid is able to capture high-resolution images of the cosmos, revealing cosmic secrets waiting to be uncovered. These captivating images provide a glimpse into the vastness and beauty of our universe.

Euclid’s main objective is to create the most comprehensive 3D map of the universe ever recorded. Over its six-year mission, the telescope will generate an immense amount of data, equivalent to a million DVDs. This massive amount of data will be crucial in unraveling the mysteries surrounding dark matter and dark energy.

Space Force and SpaceX announced that they’ve reached a deal for a brand-new military capability: Starshield. Is it a new laser defense shield against nuclear missiles? An Ultron for our time to destroy alien armadas? Or Starlink, but with new branding and (probably) a new fleet of satellites?

Yup, the last one. But with how clutch Starlink is in Ukraine, a military-controlled version of the network could change operations there. And it would dramatically improve U.S. and allied military communications in future conflicts. Now, the American military will lead military space-based communications with the start of Starshield. But expect allies to clamor aboard and other nations to try developing rival platforms.

Space Force has one of the most descriptive, succinct names in the modern military, but it appears to be even worse at naming its programs than the other branches. Still, its Proliferated Low Earth Orbit Program, or “PLEOP,” for acronym addicts who want to hear the sound of a dump every time they discuss the program, is promising.

These risks may be amplified with longer-lasting treatments, as Dr. Shafipour cautioned:

“Higher levels of GLP-1 are associated with more gastrointestinal side effects, including nausea, acid reflux, constipation, and bloating, which in some individuals, could be a cause for discontinuation of the drug.”

However, she added: “If this is not a side effect due to this novel technology, this could be a great advantage over the current GLP-1 receptor agonists.”

A new study reveals a previously undiscovered way that we can feel light touches: directly through our hair follicles.

Before now, it was thought that only nerve endings in the skin and around the hair follicles could transmit the sensation.

The team behind the study, led by researchers from Imperial College London in the UK, used an RNA sequencing process to find that cells in part of the hair follicle called the outer root sheath (ORS) had a higher percentage of touch-sensitive receptors than equivalent cells in the skin.

#HumanEvolution #UnipolarWorldOrder #MultipolarWorldOrder #GlobalBrain #GenerativeAdversarialNetworks #GlobalMind #SyntellectHypothesis #Geomind

What may seem like discord and chaos at first glance is, in actuality, the driving force behind harmony, balance, and evolutionary progress. In this grand cosmic symphony, each note—be it dissonant or melodious—has its unique place, contributing to the overarching masterpiece that is the universe. Thus, the ongoing struggle of opposites is not a malign cosmic joke but rather the divine mechanism through which the universe finds its equilibrium. And so, amid all the clashing and clamor, let’s not forget: even chaos has a purpose, and that purpose is nothing short of cosmic harmony.

-Alex Vikoulov

Continue reading “The Dialectics of Chaos and Order: A Digital Philosophy Perspective” »

Epigenetics, the chemical mechanisms that controls the activity of genes, allows our cells, tissues and organs to adapt to the changing circumstances of the environment around us. This advantage can become a drawback, though, as this epigenetic regulation can be more easily altered by toxins than the more stable genetic sequence of the DNA.

An article recently published at Science with the collaboration of the groups of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute (IJC-CERCA), ICREA Research Professor and Chairman of Genetics at the University of Barcelona, and Dr. Lucas Pontel, Ramon y Cajal Fellow also of the Josep Carreras Institute, demonstrates that the substance called formaldehyde, commonly present in various household and cosmetic products, in polluted air, and widely used in construction, is a powerful modifier of normal epigenetic patterns.

The publication is led by Dr. Christopher J. Chang, of the University of California Berkeley in the United States, whose research group is pioneer in the study of the effects of various chemical products on cell metabolism. The research has focused on investigating the effects of high concentrations of formaldehyde in the body, a substance already been associated with an increased risk of developing cancer (nasopharyngeal tumours and leukaemia), hepatic degeneration due to fatty liver (steatosis) and asthma. Dr. Esteller points out that this is relevant because “formaldehyde enters our body mainly during our breathing and, because it dissolves well in an aqueous medium, it ends up reaching all the cells of our body”.

On its way to the Trojan swarms, the spacecraft made a pit stop at a rock named Dinkinesh — and the images it sent back revealed that this asteroid has its own moon.