Lifeboat Foundation

Weak laser light confined at the apex of a scanning tunnelling microscope tip can drive the tautomerization of a free-base phthalocyanine with atomic-scale precision. The combination of tip-enhanced photoluminescence spectroscopy and hyperspectral mapping paired with theoretical modelling then unravel an excited-state mediated reaction.

We now have a standard model of cosmology, the current version of the Big Bang theory. Although it has proved very successful, its consequences are staggering. We know only 5% of the content of the universe, which is normal matter. The remaining 95% is made up of two exotic entities that have never been produced in the laboratory and whose physical nature is still unknown.

These are dark matter, which accounts for 25% of the content of the cosmos, and dark energy, which contributes 70%. In the standard model of cosmology, dark energy is the energy of empty space, and its density remains constant throughout the evolution of the universe.

According to this theory, sound waves propagated in the very early universe. In those early stages, the universe had an enormous temperature and density. The pressure in this initial gas tried to push the particles that formed it apart, while gravity tried to pull them together, and the competition between the two forces created sound waves that propagated from the beginning of the universe until about 400,000 years after the Big Bang.

It might sound like something from science fiction, but the holographic principle might help us answer the biggest problem in modern physics.

Unless we solve the problem of consciousness, the endeavour remains a dead end.

Replication Crisis.

Revisiting the self-refilling bowl of soup.

A replication of a study is called into question by scientific misconduct.

Simple rules in simple settings continue to puzzle mathematicians, even as they devise intricate tools to analyze them.

Gene regulation in animals depends chiefly on enhancers, yet the underlying mechanisms are poorly understood. This Review discusses enhancer–promoter interactions and transcription activation, focusing on how enhancer–promoter selectivity is achieved and on recent technical advances that may provide new insights into transcription activation.

The miniaturization of spectrometers to a submillimeter-scale footprint opens opportunities for applications in hyperspectral imaging and lab-on-a-chip systems. Here, the authors report a high-performance single-pixel photodetector spectrometer based on the III-V semiconductor p-graded-n junction, featuring a voltage-tunable optical response.

Whether matter could engender cogitation was a very divisive topic of early modern reflection. In his polemic with Descartes, Gassendi appeared to endorse a ‘materialistic’ understanding of cognition. Two objections by Gassendi were particularly relevant to this claim: he challenged the distinction between imagination and intellect, and argued that animal and human cognition only differed quantitatively. Since the intellect was traditionally seen as immaterial, while the imagination was understood as a bodily faculty, these claims appeared to entail a naturalized image of the human soul, and the potential that matter could generate cogitation. Here, I argue that Gassendi’s claims were not only a result of his polemical vein against Descartes; rather, they were part of an intellectual agenda that Gassendi had been pursuing since the early 1620s. I then analyse Gassendi’s change of perspective in Animadversiones (1649) and Syntagma philosophicum (1658), where Gassendi presented arguments for the immateriality of the intellect and its true distinction from the imagination. I argue that Gassendi’s early objections against Descartes provided him with material to revise his own position on these subjects. I then show some of the implications of such a change of heart. Lastly, I address some hypotheses of its cause.

Whether matter in general, and vital matter in particular, could engender cogitation was a much-discussed and divisive topic of early modern reflection. Crucial to this debate was the issue of the distinction between animal and human thinking faculties. Generally, both men and animals were believed to possess imagination or phantasy—a faculty that was seen as depending on the body. Conversely, only men could perform higher thinking by virtue of their possession of the intellect; in turn, this was commonly identified with an operation of the immaterial soul. However, early modern authors sometimes downplayed these distinctions, for instance by presenting a purely materialistic explanation of the soul and of its functions. In doing so, they brought attention, whether explicitly or implicitly, to the ability of vital matter to generate cognition.