Lifeboat Foundation

The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells comprising the immune system is lacking. Here, we estimated the abundance of the primary immune cell types throughout all tissues in the human body. We conducted a literature survey and integrated data from multiplexed imaging and methylome-based deconvolution. We also considered cellular mass to determine the distribution of immune cells in terms of both number and total mass. Our results indicate that the immune system of a reference 73 kg man consists of 1.8 × 10¹² cells (95% CI 1.5–2.3 × 10¹²), weighing 1.2 kg (95% CI 0.8–1.9). Lymphocytes constitute 40% of the total number of immune cells and 15% of the mass and are mainly located in the lymph nodes and spleen. Neutrophils account for similar proportions of both the number and total mass of immune cells, with most neutrophils residing in the bone marrow. Macrophages, present in most tissues, account for 10% of immune cells but contribute nearly 50% of the total cellular mass due to their large size. The quantification of immune cells within the human body presented here can serve to understand the immune function better and facilitate quantitative modeling of this vital system.

Astronomers studying data from NASA’s retired Kepler space telescope discovered a new system of seven “scorching” planets orbiting a distant star that is bigger and hotter than the sun, the space agency said Thursday.

NASA described the newly found planets as “sweltering” and “bathed” in radiant heat emitted by the host star that was described as “sun-like.” That star is 10% larger and 5% “hotter than the sun,” NASA said, and there is more heat per area from that star than any planet in our solar system experiences.

All of the planets are larger than Earth, with the two inner planets just slightly larger and the other five planets even bigger, about twice the size of Earth. The inner planets are “probably rocky and may have thin atmospheres,” NASA said, while the five outer planets are expected to have thick atmospheres.

In order to survive, organisms must control the pressure inside them, from the single-cell level to tissues and organs. Measuring these pressures in living cells and tissues in physiological conditions is a challenge.

In research that has its origin at UC Santa Barbara, scientists now at the Cluster of Excellence Physics of Life (PoL) at the Technical University in Dresden (TU Dresden), Germany, report in the journal Nature Communications a new technique to ‘visualize’ these pressures as organisms develop. These measurements can help understand how cells and tissues survive under pressure, and reveal how problems in regulating pressures lead to disease.

When molecules dissolved in water are separated into different compartments, water has the tendency to flow from one compartment to another to equilibrate their concentrations, a process known as osmosis. If some molecules cannot cross the membrane that separates them, a pressure imbalance—osmotic pressure—builds up between compartments.

In a recent study published in Nature Communications, researchers report that osteoarthritis (OA) is caused by the loss of Gremlin 1 (Grem1)-lineage chondrogenic progenitor (CP) cells.

Study: Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Image Credit: airdone / Shutterstock.com.

Despite exciting advances in gene editing, the efficient delivery of genetic tools to extrahepatic tissues remains challenging. This holds particularly true for the skin, which poses a highly restrictive delivery barrier. In this study, we ran a head-to-head comparison between Cas9 mRNA or ribonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) to deliver gene editing tools into epidermal layers of human skin, aiming for in situ gene editing. We observed distinct LNP composition and cell-specific effects such as an extended presence of RNP in slow-cycling epithelial cells for up to 72 h. While obtaining similar gene editing rates using Cas9 RNP and mRNA with MC3-based LNPs (10–16%), mRNA-loaded LNPs proved to be more cytotoxic. Interestingly, ionizable lipids with a p K_a ∼ 7.1 yielded superior gene editing rates (55%–72%) in two-dimensional (2D) epithelial cells while no single guide RNA-dependent off-target effects were detectable. Unexpectedly, these high 2D editing efficacies did not translate to actual skin tissue where overall gene editing rates between 5%–12% were achieved after a single application and irrespective of the LNP composition. Finally, we successfully base-corrected a disease-causing mutation with an efficacy of ∼5% in autosomal recessive congenital ichthyosis patient cells, showcasing the potential of this strategy for the treatment of monogenic skin diseases. Taken together, this study demonstrates the feasibility of an in situ correction of disease-causing mutations in the skin that could provide effective treatment and potentially even a cure for rare, monogenic, and common skin diseases.

Link :- https://interestingengineering.com/science/blood-test-detect…tent=Nov03

Angelp/iStock.

Scientists are looking for specific DNA, cells, and molecules in our body which may be cancerous. They’ve made progress in finding some of these markers in the blood, but it’s still tricky to find them accurately and affordably for routine screening.

A team of researchers has now been able to show that there is an incredibly high biodiversity of environmentally relevant microorganisms in nature. This diversity is at least 4.5 times greater than previously known. The researchers recently published their findings in the journals Nature Communications and FEMS Microbiology Reviews.

The hidden world of microorganisms is often overlooked, even though many climate-relevant processes are influenced by microorganisms, often associated with an incredible diversity of species within the groups of bacteria and archaea (“primitive bacteria”).

For example, sulfate-reducing microorganisms convert a third of the organic carbon in marine sediments into carbon dioxide. This produces toxic hydrogen sulfide. On the positive side, sulfur-oxidizing microorganisms quickly use this as an energy source and render it harmless.

A giant underground pyramid hidden beneath a hillside in Indonesia far outdates Stonehenge or the Giza Pyramids and may come to rival the oldest megalithic structures ever built by human hands.

Remember the name Gunung Padang.

The exceptional hillside of ancient stone structures on the island of West Java is sacred to locals, who call this kind of structure a ‘punden berundak’, meaning stepped pyramid, for the terraces that lead to its peak.

A scientist claims to have developed an inexpensive system for using quantum computing to crack RSA, which is the world’s most commonly used public key algorithm.

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The response from multiple cryptographers and security experts is: Sounds great if true, but can you prove it? “I would be very surprised if RSA-2048 had been broken,” Alan Woodward, a professor of computer science at England’s University of Surrey, told me.