Lifeboat Foundation

The psychedelic substances 5-MeO-DMT causes a long-lasting increase in the number of tiny protrusions called dendritic spines in the brain, according to new research published in Neuropsychopharmacology. The study, which was conducted on mice, sheds light on the behavioral and neural mechanisms of 5-MeO-DMT.

Serotonergic psychedelics (such as psilocybin and LSD) have shown promise as potential therapeutics for mental illnesses like depression and anxiety. Short-acting compounds are particularly interesting because they require less dosing time, which could improve patient access to treatment. In humans, 5-MeO-DMT produces a short-lasting experience due to its rapid breakdown in the body.

“My lab started research on psychiatric drugs like ketamine and psychedelics about 10 years ago. We were motivated by how basic science and clinical research can together powerfully move a drug forward to become medicine. Specifically I believe there is a lot of potential for psychedelics as therapeutics, and that drives our interest in this topic,” said study author Alex Kwan (@kwanalexc), an associate professor in the Meinig School of Biomedical Engineering at Cornell University.

The startup tested its technology on primates for several years.

Language models similar to ChatGPT have started to transform neuroscience.

The billionaire’s Neuralink implant company wants to help restore people’s vision and mobility.

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Neuralink, Elon Musk’s brain-implant company, said on Thursday it had received a green light from the US Food and Drug Administration (FDA) to kickstart its first in-human clinical study, a critical milestone after earlier struggles to gain approval.

Musk has predicted on at least four occasions since 2019 that his medical device company would begin human trials for a brain implant to treat severe conditions such as paralysis and blindness.

Continue reading “Elon Musk’s brain implant company Neuralink approved for in-human study” »

Implanted brain electrodes send signals that bypass damaged spinal cord area, using man’s thoughts to stimulate leg movement.

Scientists have found a way to restore the brain and spinal cord interface, developing an implantable device that enables paralyzed patient to stand and walk again.

A spinal cord injury (SCI) can be debilitating for some people, making it difficult for them to walk normally again. Some individuals may take weeks to recover their ability to walk after an injury, while others may take months or even suffer from paralysis.

This is mainly due to the SCI hindering communication between the brain and the region of the spinal cord responsible for limb movement.

In short blood dilution is very, very good for you.

In this talk, Dr. Irina Conboy discusses the role of repair and regeneration in lifespan and healthspan, contending that these factors, rather than entropy and time progression, truly govern our aging process. She describes the research her team is pursuing, investigating whether improving the efficiency of bodily repair in older individuals could effectively make them younger. She suggests that biological age could potentially be reversed and discusses heterochronic parabiosis and plasma dilution as potential ways to accomplish that. Conboy highlights recent research suggesting that old blood has a greater impact on cellular health and function than young blood. She presents her team’s experimental research on the rejuvenation effects of plasma dilution, demonstrating its significant impact on reducing senescence, neuroinflammation, and promoting neurogenesis in the brains of old mice.

Continue reading “Decoding the Aging Process: The Impact of Blood Dilution on Biological Age (Irina Conboy at EARD)” »

I had an amazing experience at the Foresight Institute’s Whole-Brain Emulation (WBE) Workshop at a venue near Oxford! For more information and a list of participants, see: https://foresight.org/whole-brain-emulation-workshop-2023/ I had the opportunity to work within a group of some of the most brilliant, ambitious, and visionary people I’ve ever encountered on the quest for recreating the human brain in a computer. We also discussed in depth the existential risks of upcoming artificial superintelligence and how to mitigate these risks, perhaps with the aid of WBE.

My subgroup focused on exploring the challenge of human connectomics (mapping all of the neurons and synapses in the brain).

WBE is a potential technology to generate software intelligence that is human-aligned simply by being based directly on human brains. Generally past discussions have assumed a fairly long timeline to WBE, while past AGI timelines had broad uncertainty. There were also concerns that the neuroscience of WBE might boost AGI capability development without helping safety, although no consensus did develop. Recently many people have updated their AGI timelines towards earlier development, raising safety concerns. That has led some people to consider whether WBE development could be significantly speeded up, producing a differential technology development re-ordering of technology arrival that might lessen the risk of unaligned AGI by the presence of aligned software intelligence.