Lifeboat Foundation

Studies on the synthesis and application of chiral materials has important scientific significance and market value. However, the design, synthesis and application of chiral materials are still in their infancy, and relevant research is limited to natural chiral polymer materials and very few artificial synthetic chiral materials.

In response to the key problems of synthesis, characterization, and mechanism research in the field of chiral materials, researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences have proposed a novel concept of “asymmetric kinetic resolution polymerization” (AKRP), which provides a new method for the efficient synthesis, direct characterization of chiral polymer materials, and a new approach for studying the reaction mechanism of asymmetric polymerization.

The challenge in achieving AKRP is the design and synthesis of highly enantioselective catalysts. To solve this problem, the researchers proposed the “dual-ligand” strategy for the first time, enabling the highly enantioselective chiral (BisSalen)Al catalysts. The research is published in Journal of the American Chemical Society.

The barren, dusty Red Planet was not always a lifeless mess. In fact, scientists have often theorized that Mars was once covered in vast waterways. There’s a lot of evidence to suggest that may be the case, too. However, new research involving that evidence suggests that it might not have been water that left those marks after all and that the chance of finding life on Mars is actually much slimmer than we hoped.

Mars is by far the planet that humanity has explored the most, with several rovers now having made their way across the barren surface of our neighboring planet. One of the key missions with those rovers has always been to find signs of life, or signs that life once existed on Mars. We’ve come close a couple of times, with some theorizing that NASA accidentally killed the only Martian life we’ve ever discovered on the planet.

Through it all, though, the hope that our chances to find life on Mars were high has relied on one key thing: the existence of water in Mars’s past. However, that watery past we believe the planet had may not have been as long or as extensive as we thought. New evidence suggests that places we thought had been carved out by water flowing through them could have actually been created by explosively evaporating carbon dioxide ice.

Scientists transplant a pig’s liver into a brain-dead patient with no organ rejection. This may solve the problem of scarcity of donors.

The immune system is comprised of two separate responses referred to as either innate or adaptive immunity. Both work in collaboration to elicit protection against anything the body encounters as ‘foreign’. In many cases foreign pathogens that enter the body are recognized by the innate immune system first which then activate adaptive immunity. The innate immune system uses many broad, non-specific cells to detect anything that might cause harm to the body. These cells initiate inflammation and the overall immune response. The adaptive immune system comes second and is more specific to the invading pathogen. Adaptive immune cells can not only help lyse or kill the invaders, but also generate cells to ‘remember’ that pathogen in the future. This is a common phenomenon that occurs when we overcome an illness and is known as immunological memory. Vaccine biology is based on this concept that we will generate ‘memory cells’ in response to attenuated viruses.

The study of immunity and how our body fights off disease is a progressively growing field. Currently, scientists know many of the key players that drive this immunological memory. However, researchers and physicians are working together to better understand this process and how to generate more effective treatments for various diseases. An exciting article in Nature, published by Dr. Francisco J. Quintana and others, demonstrate that a glial cell can generate immunological memory. Quintana, an investigator at Brigham and Women’s Hospital, and his team study different signaling pathways associated with immune activity to identify novel therapeutic treatments and biomarkers to measure treatment efficacy. The glial cell Quintana and his team found to aid in immunity is known as an astrocyte, which is a key cell within the central nervous system (CNS). Astrocytes help promote synapse formation, clear excess neurotransmitters, and maintain the blood-brain barrier.

For the first time astrocytes have been connected to obtain memory-like properties and aid in immunity. The team used multiple models to demonstrate that astrocytes can remember previous interactions with immune cells. Not only did this function improve response time to infection but induced a stronger immune response when re-exposed to the same disease. Due to similarities in memory formation, Quintana and others refer to this process as ‘astrocyte immune memory’. Interestingly, due to astrocytes long lifespan, these cells could provide insight into chronic neurologic disorders.

A map of mouse development from conception to birth tracks 12.4 million cells at single-cell resolution as they mature into organs and other tissues.

Sakana AI, a Tokyo-based artificial intelligence startup founded by two prominent former Google researchers, released AI models on Wednesday it said were built using a novel method inspired by evolution, akin to breeding and natural selection.

Bloomberg connects decision makers to a dynamic network of data, delivering business and financial information, news and insights globally.

The Biden administration has today announced new vehicle emission standards for 2027–2032, as it pushes for wider adoption of hybrid and electric vehicles.

Tesla Model 3 at a charging station in Delaware, United States. Credit: K.A

Automobile emissions in the United States could be slashed by half within the next eight years, thanks to new standards finalised and published today by the Environmental Protection Agency (EPA). The ambitious set of rules – not only aimed at reducing air pollution, but also cutting fuel costs – are to be phased in between 2027 and 2032.

Researchers from the Oxford Martin Programme on Ethical Web and Data Architectures (EWADA), University of Oxford, have called for a more considered approach when embedding ethical principles in the development and governance of AI for children.