Lifeboat Foundation

Neurodevelopmental disorders (NDDs) are a group of disorders in which the development of the central nervous system (CNS) is disturbed, resulting in different neurological and neuropsychiatric features, such as impaired motor function, learning, language or non-verbal communication. Frequent comorbidities include epilepsy and movement disorders. Advances in DNA sequencing technologies revealed identifiable genetic causes in an increasingly large proportion of NDDs, highlighting the need of experimental approaches to investigate the defective genes and the molecular pathways implicated in abnormal brain development. However, targeted approaches to investigate specific molecular defects and their implications in human brain dysfunction are prevented by limited access to patient-derived brain tissues. In this context, advances of both stem cell technologies and genome editing strategies during the last decade led to the generation of three-dimensional (3D) in vitro-models of cerebral organoids, holding the potential to recapitulate precise stages of human brain development with the aim of personalized diagnostic and therapeutic approaches. Recent progresses allowed to generate 3D-structures of both neuronal and non-neuronal cell types and develop either whole-brain or region-specific cerebral organoids in order to investigate in vitro key brain developmental processes, such as neuronal cell morphogenesis, migration and connectivity. In this review, we summarized emerging methodological approaches in the field of brain organoid technologies and their application to dissect disease mechanisms underlying an array of pediatric brain developmental disorders, with a particular focus on autism spectrum disorders (ASDs) and epileptic encephalopathies.

Neurodevelopmental disorders (NDDs) encompass a range of frequently co-existing conditions that include intellectual disability (ID), developmental delay (DD), and autism spectrum disorders (ASDs) (Heyne et al., 2018; Salpietro et al., 2019). ASDs represent a complex set of behaviorally defined phenotypes, characterized by impairments in social interaction, communication and restricted or stereotyped behaviors (Chen et al., 2018). Epilepsy and NDDs frequently occur together, and when refractory seizures are accompanied by cognitive slowing or regression, patients are considered to have an epileptic encephalopathy (EE) (Scheffer et al., 2017). Both ID and ASDs are clinically and etiologically heterogeneous and a unifying pathophysiology has not yet been identified for either the disorder as a whole or its core behavioral components (Myers et al., 2020). Family and twin studies suggest high (0.65–0.91) heritability (Chen et al.

Whereas traditional colonoscopy involves snaking a camera called a colonoscope through your colon and rectum, a CT colonography, or virtual colonoscopy, consists of X-rays and a computer creating 3D images of these organs.

If you’re between the ages of 45 and 85, you should have a colorectal cancer screening routine in place, per the American Cancer Society (ACS). But a colonoscopy —in which your doctor uses a special camera to look inside your colon and rectum in search of abnormal growths called polyps —isn’t the only option to take charge of your gastrointestinal health.

You can choose from noninvasive screening methods: computed tomography (CT) colonography and/or a stool-based test. Billionaire entrepreneur and Shark Tank investor Mark Cuban tells Fortune he enjoys the relatively low cost and simplicity of the former, also called virtual colonoscopy. In short, it’s an X-ray exam that doesn’t require sedation or anesthesia.

A destructive storm system spawned new tornadoes and heavy rain as it moved east pummeling multiple states. Kentucky’s governor has declared a state of emergency after three confirmed tornadoes. NBC’s Maggie Vespa reports and TODAY’s Al Roker tracks the latest forecast.

https://youtube.com/watch?v=UamFgixecF0

Learn about Corning Willow Glass, an ultra-thin, conformable, flexible glass fusion-formed for an incredibly smooth, flat surface, virtually free of defects.

Year 2023 face_with_colon_three

The new manufacturing method deals with the packaging substrate, the material to which chip dies are bonded. Intel and others have long used plastic (also known as organic) substrates, but the material can shrink or warp during the chip-making process, leading to defects.

Continue reading “Intel to Build Next-Generation Chips Using ‘Glass Substrate’” »

Year 2013 face_with_colon_three

We need them because thin, pliable organic semiconductors are too slow to serve in tomorrow’s 3‑D chips.

The recent development of AI presents challenges, but also great opportunities. In this clip I will discuss the topiv in general.
… whar hasn’t worked perfectly is AI sound post-production, I apologize smile

Mind also my backup channel:
https://odysee.com/@TheMachian: c.
My books: www.amazon.com/Alexander-Unzicker/e/B00DQCRYYY/

The first crewed test launch of Boeing’s troubled Starliner spacecraft has been delayed yet again.

This time, however, it’s seemingly not about the aerospace giant’s massive technical difficulties in getting its astronaut shuttle off the ground — with or without a crew on board.

“Following a review of the International Space Station operations, NASA’s Boeing Crew Flight Test now is targeting no earlier than Monday, May 6, for Starliner’s first launch with astronauts to the orbital complex,” reads an official NASA update. “The date adjustment optimizes space station schedule of activities planned toward the end of April, including a cargo spacecraft undocking and a crew spacecraft port relocation required for Starliner docking.”

The total solar eclipse isn’t the only reason to keep your eyes to the sky this year. For the first time in 80 years, a star system 3,000 light years away will be visible to the naked eye thanks to a once-in-a-lifetime nova outburst.

NASA announced that the nova, which will create a “new” star in the night sky, will light up the night sky some time between now and September and be as bright as the North Star. One of only five recurring novae in our galaxy, it will be visible for a week before it fades back down.

Jonathan Blazek, an assistant professor of physics at Northeastern University, says this is an exciting moment for amateur astronomers and astrophysicists alike. It’s not technically a new star, just a star that is now bright enough for people to see more clearly, Blazek says, but it provides an opportunity to see and understand the cosmos in a new way.