Lifeboat Foundation

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Nano electron guns can help zap cancers and drive new classes of lasers.

From medication to therapy, see how you can relieve back pain caused by ankylosing spondylitis of the spine.

A cholesterol-lowering drug may help reduce the risk of heart failure in people with lymphoma who receive chemotherapy drugs called anthracyclines, results from a clinical trial suggest.

Anthracyclines, such as doxorubicin, are used to treat many types of cancer. But these drugs may affect the heart’s ability to pump blood, potentially leading to heart failure.

In the trial, atorvastatin (Lipitor) was found to reduce the risk of some cardiac changes linked to heart failure among patients treated with anthracyclines.

The anti–PD-1 agent tislelizumab was noninferior, but not superior, to the tyrosine kinase inhibitor sorafenib for unresectable hepatocellular cancer.

First-line treatment for patients with unresectable hepatocellular cancer (HCC) is either combination immunotherapy with bevacizumab and atezolizumab or tremelimumab and durvalumab. Although immunotherapy-based combination therapy has replaced tyrosine kinase inhibitors (TKIs) as initial therapy, randomized trials have not indicated superiority of single agent anti–PD-1 or PD-L1 therapy over TKIs.

Investigators have now conducted an industry-sponsored, global, open-label, randomized, phase 3 trial (RATIONALE-301) to compare first-line treatment with the anti–PD-1 agent tislelizumab versus the TKI sorafenib in 674 patients with Child-Pugh class A unresectable HCC. Of the patients, 85% were men, 58% had distant metastases, 76% had received prior locoregional therapy, 60% had hepatitis B, 13% had hepatitis C, and 3% had hepatitis B and C.

The primary endpoint of noninferiority for overall survival (OS) was achieved with tislelizumab compared with sorafenib (median 15.9 vs. 14.1 months; hazard ratio, 0.85; 95% confidence interval, 0.71–1.02), reaching the noninferiority margin upper limit of a hazard ratio 1.08. Superiority for OS with tislelizumab was not met. Antitumor response was numerically higher with tislelizumab than with sorafenib (14.3% vs. 5.4%), and median duration of response was longer with tislelizumab than with sorafenib (36.1 vs. 11.0 months). Median progression-free survival was similar with tislelizumab and sorafenib (2.1 and 3.4 months, respectively). Grade 3–4 treatment-related adverse events were more common with sorafenib than with tislelizumab (53.4% vs. 22.2%).

Continue reading “Tislelizumab vs. Sorafenib for Unresectable Hepatocellular Cancer” »

An international research consortium led by Ludwig Maximilian University of Munich (LMU) has tested a rapid new analytical tool which needs just a blood sample from the fingertip.

About 240,000 children worldwide die of tuberculosis every year. The disease is among the top 10 causes of death in children under the age of 5. One of the main reasons for this mortality is that tuberculosis is often misdiagnosed or not diagnosed in time, particularly in regions with limited resources.

A new diagnostic tool, which an international research consortium led by LMU medical scientists Laura Olbrich and Norbert Heinrich from the Division of Infectious Diseases and Tropical Medicine at LMU University Hospital Munich has tested as part of a large-scale study in five countries, offers significant progress in this area. The authors report on their findings in The Lancet Infectious Diseases.

A recent experiment suggests the brain is not too warm or wet for consciousness to exist as a quantum wave that connects with the rest of the universe.

Even as toddlers, we have an uncanny ability to turn what we learn about the world into concepts. With just a few examples, we form an idea of what makes a “dog” or what it means to “jump” or “skip.” These concepts are effortlessly mixed and matched inside our heads, resulting in a toddler pointing at a prairie dog and screaming, “But that’s not a dog!”

Last week, a team from New York University created an AI model that mimics a toddler’s ability to generalize language learning. In a nutshell, generalization is a sort of flexible thinking that lets us use newly learned words in new contexts—like an older millennial struggling to catch up with Gen Z lingo.

When pitted against adult humans in a language task for generalization, the model matched their performance. It also beat GPT-4, the AI algorithm behind ChatGPT.

Summary: Scientists unraveled how animals differentiate distinct scents, even those that seem remarkably similar.

While some neurons consistently identify differing smells, others respond unpredictably, aiding in distinguishing nuanced aromas over time. This discovery, inspired by previous research on fruit flies, could enhance machine-learning models.

By introducing variability, AI might mirror the discernment found in nature.