Lifeboat Foundation

The Y chromosome is a never-ending source of fascination (particularly to men) because it bears genes that determine maleness and make sperm. It’s also small and seriously weird; it carries few genes and is full of junk DNA that makes it horrendous to sequence.

However, new “long-read” sequencing techniques have finally provided a reliable sequence from one end of the Y to the other. The paper describing this Herculean effort has been published in Nature.

The findings provide a solid base to explore how genes for sex and sperm work, how the Y chromosome evolved, and whether—as predicted—it will disappear in a few million years.

Female kidneys are known to be more resilient to disease and injury, but males need not despair. A new USC Stem Cell-led study published in Developmental Cell describes not only how sex hormones drive differences in male and female mouse kidneys, but also how lowering testosterone can “feminize” this organ and improve its resilience.

“By exploring how differences emerge in male and female kidneys during development, we can better understand how to address sex-related health disparities for patients with kidney diseases,” said Professor Andy McMahon, the study’s corresponding author, and the director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of USC.

First authors Lingyun “Ivy” Xiong and Jing Liu from the McMahon Lab and their collaborators identified more than 1,000 genes with different levels of activity in male and female mouse kidneys, in a study supported by the National Institutes of Health. The differences were most evident in the section of the kidney’s filtering unit known as the proximal tubule, responsible for reabsorbing most of the nutrients such as glucose and amino acids back into the blood stream.

A new study reveals the brain circuit that controls sex drive in male mice. Scientists believe this finding could apply to humans and may allow them to manipulate the male libido.

Scientists at Stanford Medicine have identified the exact part of the brain that controls sex drive in mice. It is possible that the same part of the human brain also regulates libido in men.

“We’ve singled out a circuit in male mammals’ brains that controls sexual recognition, libido, and mating behavior and pleasure,” said Nirao Shah, one of the senior researchers and a professor of behavioral sciences at Stanford.

One of the smallest chromosomes in humans, the male sex chromosome is the final one to be fully sequenced.

Brain age was estimated using an algorithm that combined multiple measures of brain structure obtained through MRI scans when the participants were 45 years old. This algorithm quantified the difference between estimated brain age and the participants’ chronological age, referred to as brain age gap estimate.

If the estimated brain age is higher than the chronological age, it suggests that the brain’s structural characteristics are more similar to those of an older individual. Conversely, if the estimated brain age is lower than the chronological age, the brain’s structural characteristics resemble those of a younger individual.

Lay-Yee and his colleagues also adjusted their analyses for various potential confounding factors. These included socio-demographic factors like sex and socio-economic status, as well as family factors (teen-aged mother, single parent, change in residence, maltreatment) and child-behavioral factors (self-control, worry/fearfulness).

People are having sex in the backseat while their driverless robotaxi is ferrying them to their final destination in San Francisco.

Scientists may have successfully spotted the brain center for the male libido responsible for sexual interest and mating in mouse models. The discovery may lead to improved drugs for sexual function.

This is according to a report by Medical Xpress published on Friday.

Senior researcher Dr. Nirao Shah, a professor of psychiatry and neurobiology at Stanford University School of Medicine, in California, said in the article that the newly-discovered region is responsible for recognizing the sex of other mice.

Summary: This week’s neuroscience revelations encompass intriguing findings from the enigmatic genetics of mind-controlling hairworms to the groundbreaking link between alcohol use disorders and certain neuronal plasticity genes.

A novel theory proposes that the location of memory storage in the brain depends on its generalizability rather than age, adding a new dimension to our understanding of memory management. A new AI system demonstrates an impressive ability to identify violations of social norms, promising advancements in AI capabilities.

Continue reading “Brain Bites: Top 5 Neuroscience News Articles of the Week” »

Gay sex – some humans do it, some penguins do it, and as it turns out, many monkeys do it. It’s only natural, according to a study published Monday in the journal Nature Ecology and Evolution.

By watching a group of rhesus macaques over a three-year period in Puerto Rico, scientists from the Imperial College of London found it was more common for the males to engage in sex with the same gender than with the opposite.

The researchers reported 72% of the 236 male monkeys either mounted, or were mounted, by other males, whereas only 46% participated in heterosexual sex.