Lifeboat Foundation

Julia Greer discusses her life background and research career in this five-part oral history.

Study reveals an important discovery in the realm of nanomachines within living systems. Prof. Sason Shaik from the Hebrew University of Jerusalem and Dr. Kshatresh Dutta Dubey from Shiv Nadar University, conducted molecular-dynamics simulations of Cytochromes P450 (CYP450s) enzymes, revealing that these enzymes exhibit unique soft-robotic properties.

Cytochromes P450 (CYP450s) are enzymes found in living organisms and play a crucial role in various biological processes, particularly in the metabolism of drugs and xenobiotics. The researchers’ simulations demonstrated that CYP450s possess a fourth dimension — the ability to sense and respond to stimuli, making them soft-robot nanomachines in “living matters.”

In the catalytic cycle of these enzymes, a molecule called a substrate binds to the enzyme. This leads to a process called oxidation. The enzyme’s structure has a confined space that allows it to act like as a sensor and a soft robot. It interacts with the substrate using weak interactions, like soft impacts. These interactions transfer energy, causing parts of the enzyme and the molecules inside it to move. This movement generates ultimately a special substance called oxoiron species, which serves the enzyme to oxidize a variety of different substances.

Sandwich compounds are special chemical compounds used as basic building blocks in organometallic chemistry. So far, their structure has always been linear.

Recently, researchers of Karlsruhe Institute of Technology (KIT) and the University of Marburg were the first to make stacked sandwich complexes form a nano-sized ring. Physical and other properties of these cyclocene structures will now be further investigated. The researchers report their findings in Nature.

Sandwich complexes were developed about 70 years ago and have a sandwich-like structure. Two flat aromatic organic rings (the “slices of bread”) are filled with a single, central metal atom in between. Like the slices of bread, both rings are arranged in parallel. Adding further layers of “bread” and “filling” produces triple or multiple sandwiches.

The next generation of 2D semiconductor materials doesn’t like what it sees when it looks in the mirror. Current synthesizing approaches to make single-layer nanosheets of semiconducting material for atomically thin electronics develop a peculiar “mirror twin” defect when the material is deposited on single-crystal substrates like sapphire. The synthesized nanosheet contains grain boundaries that act as a mirror, with the arrangement of atoms on each side organized in reflected opposition to one another.

This is a problem, according to researchers from the Penn State’s Two-Dimensional Crystal Consortium-Materials Innovation Platform (2DCC-MIP) and their collaborators. Electrons scatter when they hit the boundary, reducing the performance of devices like transistors. This is a bottleneck, the researchers said, for the advancement of next-generation electronics for applications such as Internet of Things and artificial intelligence. But now, the research team may have come up with a solution to correct this defect. They have published their work in Nature Nanotechnology.

This study could have a significant impact on semiconductor research by enabling other researchers to reduce mirror twin defects, according to lead author Joan Redwing, director of 2DCC-MIP, especially as the field has increased attention and funding from the CHIPS and Science Act approved last year. The legislation’s authorization increased funding and other resources to boost America’s efforts to onshore the production and development of semiconductor technology.

Seitz et al. use DNA origami as a scaffold for viral capsid proteins to create virus capsids in the shapes of rings, tubes, and more! They employ cryo-EM to obtain 3D structures of some of their nanomolecular constructs and they show that multi-layer capsids occur at high concentrations of capsid proteins. Exciting work! #nanotechnology #biotechnology #syntheticbiology #genetherapy

DNA and RNA origami nanostructures direct the size, shape and topology of different virus capsids in a user-defined manner while shielding encapsulated origamis from degradation.

Still a big maybe but it gives them other ideas/possibilities. Hopefully they succeed soon! My mother has glaucoma. It’ll probably be decades before this cure happens though. Unless it can be accelerated which is predicted by Ray Kurzweil in his book The Singularity is Near. I think other futurists have said similar things though I’m not familiar with all of them, I saw a talk by one for NASA.

In efforts to tackle the leading cause of blindness in developed countries, researchers have recruited nanotechnology to help regrow retinal cells.

Macular degeneration is a form of central vision loss, which has massive social, mobility, and mental consequences. It impacts hundreds of millions of people globally and is increasing in prevalence.

Continue reading “Scientists Regrow Retinal Cells in The Lab Using Nanotechnology” »

A German-Chinese research team has successfully created a quantum bit in a semiconductor nanostructure. Using a special energy transition, the researchers created a superposition state in a quantum dot – a tiny area of the semiconductor – in which an electron hole simultaneously possessed two different energy levels. Such superposition states are fundamental for quantum computing.

Previously, the induction of such a state necessitated a large-scale, free-electron laser capable of emitting light in the terahertz range. Unfortunately, this wavelength was too long to accurately focus the beam on the quantum dot. This team, however, achieved the excitation with two carefully calibrated, short-wavelength optical laser pulses.

The team headed by Feng Liu from Zhejiang University in Hangzhou, together with a group led by Dr. Arne Ludwig from Ruhr University Bochum and other researchers from China and the UK, report their findings in the journal Nature Nanotechnology, published online on July 24, 2023.

Optical phase retrieval and imaging appear in a wide variety of science fields, such as imaging of quasi-transparent biological samples or nanostructures metrological characterization, for example, in the semiconductor industry. At a fundamental level, the limit to imaging accuracy in classical systems comes from the intrinsic fluctuation of the illuminating light, since the photons that form it are emitted randomly by conventional sources and behave independently of one another.

Quantum correlation in light beams, in which photons show certain cooperation, can surpass those limits. Although quantum advantage obtained in phase estimation through first-order interference is well understood, interferometric schemes are not suitable for multi-parameter wide-field imaging, requiring raster scanning for extended samples.

In a new paper published in Light Science & Application, a team of scientists from the Quantum Optics Group of the Italian National Metrology Institute (INRiM), Italy, and from the Imaging Physics Dept. Optics Research Group, Faculty of Applied Sciences of Delft University of Technology, The Netherlands, has developed a technology exploiting quantum correlations to enhance imaging of phase profiles in a non-interferometric way.

Using conventional testing techniques, it can be challenging—sometimes impossible—to detect harmful contaminants such as nano-plastics, air pollutants and microbes in living organisms and natural materials. These contaminants are sometimes found in such tiny quantities that tests are unable to reliably pick them up.

This may soon change, however. Emerging nanotechnology (based on a “twisted” state of light) promises to make it easier to identify the chemical composition of impurities and their geometrical shape in samples of air, liquid and live tissue.

An international team of scientists led by physicists at the University of Bath is contributing toward this technology, which may pave the way to new environmental monitoring methods and advanced medicines. Their work is published in the journal Advanced Materials.