Lifeboat Foundation

Acute myeloid leukemia (AML) is a rare and aggressive hematologic malignancy. AML progresses rapidly and is indicated by an excess of immature white blood cells. It is caused by high mutational burden over the span of a person’s life. One signature mutated gene includes the tumor suppressor gene TP53. Normally, TP53 helps make protein to stop oncogenesis or the formation of tumors. However, mutated TP53 loses that function and commonly results in AML. Unfortunately, those that have a TP53 mutation have an extremely aggressive tumor that is resistant to conventional chemotherapy drugs and results in poor prognosis. Other standard treatments include stem-cells transplants, and sometimes targeted drugs such as intracellular pathway inhibitors. Although many treatments are routine and help the patient reduce symptoms, there is no cure. Extensive research is currently being done by researchers and physicians to identify new approaches for AML treatment.

One novel therapy used in other hematologic malignancies includes chimeric antigen receptor (CAR)-T cell therapy. This therapy takes immune T cells (responsible for lysing or kill infections) from the patient or a donor and engineers them to target the tumor. Normally, these T cells would not recognize tumor growth, therefore, the engineered CAR-T cells are programmed to elicit an immune response and recognize surface markers on the tumor to lyse it. This therapy has been successful in other leukemias such as B-cell acute leukemia, and researchers are working to overcome treatment resistant AML using the same approach.

A recent article in EMBO Molecular Medicine, by Drs. Markus Manz, Stephen Boettcher and others, demonstrate that TP53-mutated AML is resistant to CAR-T cell therapy as a single agent, but can be overcome through combination therapy. Manz and Boettcher are principal investigators from the University of Zurich and the Department of Medical Oncology and Hematology at the University Hospital Zurich (USZ) and focus on mechanisms surrounding hematological diseases. The Zurich team first reported why TP53-mutated AML is resistant to CAR-T cell therapy. Using various models, it was noted that the engineered T cells quickly become ‘exhausted’ or inactive due to overstimulation or surrounding stimuli. The team further studied the underlying mechanism in this disease by concluding that TP53-deficient cells caused resistance through several metabolic pathways. Moreover, these pathways including the mevalonate and Wnt pathways were identified to improve therapeutic efficacy.

An AI tool called Mia found missed breast cancer symptoms in the scans of 11 women during an NHS test.

Solar eruptions are sending a stream of particles towards Earth, creating spectacular auroras in both hemispheres.

The aurora borealis – in the northern hemisphere – will be potentially visible on Monday night in the US as far south as the midwest. The northern lights, more commonly seen within the Arctic Circle, could also be visible in Scotland.

Odysseus, which was built by Houston-based company Intuitive Machines, powered down one week after landing as lunar night began for 14 days. Flight controllers ordered the spacecraft to snooze for three weeks, while the moon’s south pole faced away from the sun, but they hoped Odie would reawaken once sunlight hit its solar panels again.

“Intuitive Machines started listening for Odie’s wake-up signal on March 20, when we projected enough sunlight would potentially charge the lander’s power system and turn on its radio,” representatives of the company wrote on X, formerly called Twitter.

With no biology expertise, GPT-4 performs as good or better than human experts for single-cell RNA-seq cell annotation.

This study evaluates the performance of GPT-4 in single-cell type annotation.

“For the first time we have shown that even a tiny fraction of cellular material could be identified by a mass spectrometer onboard a spacecraft,” said Dr. Fabian Klenner.

How will we find life on Jupiter’s icy moon, Europa, and Saturn’s icy moon, Enceladus? This is what a recent study published in Science Advances hopes to address as a team of international researchers investigate how ice grains that are discharged from the active plumes of these small moons could possess enough organic material for life to exist. This study holds the potential to help astrobiologists develop the necessary instruments and methods to find life on these small moons, specifically with NASA’s Europa Clipper scheduled to launch this October, whose goal will be to investigate Europa’s habitability potential.

Artist’s illustration of Saturn’s moon, Enceladus, seen here upside down as the plumes are on the south pole. (Credit: NASA/JPL-Caltech)

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AllHands.

Ask me anything on large-scale verbatim feedback via large language models.

Verbatim feedback constitutes a valuable repository of user experiences, opinions, and requirements essential for software development.

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Vernor Vinge the coming technological singularity 1993.

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The Peace Warby Vernor VingeRead by Bruce HunteyThis book was first published in 1984Audio originally issued by NLS on cassette in 1988 The Peace Authority g…