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Researchers using the new FLSHclust algorithm discovered 188 unique CRISPR-linked gene modules, including a novel type VII CRISPR-Cas system, in a massive protein database. This breakthrough enhances our understanding of CRISPR systems and their potential in biotechnological innovations.

Researchers have developed a new algorithm, FLSHclust (“flash clust”), leading to the discovery of 188 rare and previously unknown CRISPR-linked gene modules. This includes a novel type VII CRISPR-Cas system found among billions of protein sequences. The findings of this approach offer new possibilities for exploiting CRISPR systems and exploring the vast diversity of microbial proteins.

CRISPR’s Growing Impact in Biotechnology.

The flash drive of the future?

Scattered evidence suggests that aberrant proteins act as “seeds” to transmit neurodegenerative disease, but the jury is still out.

By Esther Landhuis

Not a cure all but it helps fight some cancer.

Lidocaine, a common local anesthetic, activates proteins that cause certain types of cancer cells to self-destruct.

Artificial intelligence (AI) was utilised by researchers to find a novel antibiotic that can eradicate a dangerous species of superbug. Thousands of possible substances were reduced using artificial intelligence (AI) to a small number that could be evaluated in a lab. Abaucin, a strong experimental antibiotic that was the end result, needs to undergo more testing before it can be utilised.

#superbug #AI #WION

Continue reading “New Superbug-killing antibiotic discovered | Latest World News | English News | WION” »

Good telescope that I’ve used to learn the basics: https://amzn.to/35r1jAk.
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Hello and welcome! My name is Anton I’m away for a few days due to voice issues, so enjoy this older video where we talk about the incredible invention of 3D printed bio ink that could be used to print any biological tissue (in theory). 3D printed heart anyone?

Continue reading “Bio Ink Made out of Bacteria Could Be Used to 3D Print Organs” »

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then hold those antibodies in abeyance in case they encounter that same pathogen again, the way we do. Instead, they incorporate some of the pathogen’s DNA into their own genome and link it to an enzyme that can use it to recognize that pathogenic DNA sequence and cut it to pieces if the pathogen ever turns up again.

The enzyme that does the cutting is called Cas, for CRISPR associated. Although the CRISPR-Cas system evolved as a bacterial defense mechanism, it has been harnessed and adapted by researchers as a powerful tool for genetic manipulation in laboratory studies. It also has demonstrated agricultural uses, and the first CRISPR-based therapy was just approved in the UK to treat sickle-cell disease and transfusion-dependent beta-thalassemia.

Now, researchers have developed a new way to search genomes for CRISPR-Cas-like systems. And they’ve found that we may have a lot of additional tools to work with.

A new study in mice, published recently in the journal Cell Metabolism, shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.

There’s a popular saying in some circles that “a calorie is a calorie,” but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.

“We like to say a calorie is not just a calorie,” says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health. “Different components of your diet have value and impact beyond their function as a calorie, and we’ve been digging in on one component that many people may be eating too much of.”

Beyond glycemic benefits, users of the app also reported significantly less-related emotional distress than standard care (−1.9 vs 1.7 points in composite survey scores, P =0.03).

“We are currently working on making technology like this accessible to patients outside of research settings because we think it can really help patients in underserved areas who need high-touch care to get their under control,” Nayak said.

The researchers developed their custom voice-based AI app and had it powered by Alexa (Amazon wasn’t involved with the study). The software was equipped with titration algorithms by the American Association of Clinical Endocrinologists and the American College of Endocrinology and included emergency protocols to handle hypoglycemia and hyperglycemia.