Saw this early this morning…better than getting stuck AND might work better in humans…Let’s hope! I mean, monkeys are even closer to humans than rats.
New results hint at how to perfect ‘mucosal’ vaccines, which are delivered up the nose or down the throat.
In a new paper, Sinclair and his co-authors outline a theory arguing that epigenetic changes are the underlying cause of aging [1].
It is not every day that one of the most prominent geroscientists presents a new theory of aging. David Sinclair of Harvard, along with two co-authors, Yuancheng Ryan Lu and Xiao Tian, have just published “The Information Theory of Aging” in Nature Aging. This theory was proposed by Sinclair years ago [2], and this new paper is an attempt to summarize it based on the most recent research.
The ability to store and retrieve information is central to life, which relies on the constant reproduction of complex organisms using DNA blueprints. However, on top of that digital genetic code, there is a much messier realm of epigenetics, which regulates how genetic information is translated into proteins.
A study led by researchers at Stanford Medicine questions the long-held belief that adult liver cells rarely divide:
Cells in the adult liver were thought to divide rarely. But a study led by Stanford Medicine researchers found intermittent fasting causes rapid cell division.
Why are we mentally sharper at certain times of day? A study led by Jonathan Lipton MD, Ph.D., at Boston Children’s Hospital spells out the relationship between circadian rhythms—the body’s natural day/night cycles—and the brain connections known as synapses.
The work is the first to provide a cellular and molecular explanation for natural fluctuations over the day in alertness, cognition, and the ability to learn and remember.
“We have known for more than a century that the time of day influences cognition and memory, but until now the mechanisms have been elusive,” says Lipton, a sleep physician in the Department of Neurology and researcher in the F.M. Kirby Neurobiology Center.
DNA is the building block of life, and the genetic alphabet comprises just four letters or nucleotides. These biochemical building blocks comprise all types of DNA, and scientists have long wondered whether creating working artificial DNA would be possible. Now, a breakthrough may finally provide the answer.
The main goal of a new study, the findings of which were published in Nature Communications this month, shows that scientists may finally be able to create new medicines for certain diseases by creating DNA with new nucleotides that can create custom proteins.
Being able to create artificial DNA could open the door for several important uses. Being able to expand the genetic code could very well diversify the “range of molecules we can synthesize in the lab,” the study’s senior author Dong Wang, Ph.D., explained (via Phys.org).
Scientists have fused human brain tissue to a computer chip, creating a mini cyborg in a petri dish that can perform math equations and recognize speech.
Dubbed Brainoware, the system consists of brain cells artificially grown from human stem cells, which have been fostered to develop into a brain-like tissue. This mini-brain organoid is then hooked up to traditional hardware where it acts as a physical reservoir that can capture and remember the information it receives from the computer inputs.
The researchers wanted to explore the idea of exploiting the efficiency of the human brain’s architecture to supercharge computational hardware. The rise of artificial intelligence (AI) has massively increased the demand for computing power, but it’s somewhat limited by the energy efficiency and performance of the standard silicon chips.
A hole in your throat is nothing to sneeze at, as shown by a case report recently published in BMJ Case Reports. And the case report showed the dangers of pinching your nose and closing your mouth in an attempt to stifle a sneeze. A man in his 30s tried doing this and was left with a hole is his trachea, which can be a hole lot of trouble.
This man who had a history of allergies was wearing a seat belt while driving his car when he felt the need to sneeze and in a pinch tried to keep the sneeze from exiting from either his nostrils or his mouth. This led to quite a pressure-filled situation. Normally, sneezing can generate a pressure of one to two kilopascals in the upper airways which, in turn, can blast air and accompanying gunk out through your nose and mouth. But guess what happens when you pinch your nose shut and keep your mouth closed at the same time? Rather than rushing out of these holes, the air has no place to go. That can build up pressure your the upper airways that is up to 20 times higher than what a released sneeze would generate.
After this sneezus interruptus, the man began experiencing severe neck pain and eventually ended up in the emergency department of Ninewells Hospital in Dundee, UK. The four authors of the case report (Rasads Misirovs, Gary Hoey, Calum Carruthers and Samit Majumdar) work at this hospital. There doctors found the man’s neck to be swollen on both sides. An X-ray of his neck revealed evidence of air where it wasn’t supposed to be, and a CT of the neck and chest with contrast showed a 2 mm by 2 mm by 5 mm in his trachea, otherwise known as his windpipe.
In this episode, my guest is Dr. Robert Lustig, M.D., neuroendocrinologist, professor of pediatrics at the University of California, San Francisco (UCSF), and a bestselling author on nutrition and metabolic health. We address the “calories in-calories out” (CICO) model of metabolism and weight regulation and how specific macronutrients (protein, fat, carbohydrates), fiber and sugar can modify the CICO equation. We cover how different types of sugars, specifically fructose, sugars found in liquid form, taste intensity, and other factors impact insulin levels, liver, kidney, and metabolic health. We also explore how fructose in non-fruit sources can be addictive (acting similarly to drugs of abuse) and how sugar alters brain circuits related to food cravings and satisfaction. We discuss the role of sugar in childhood and adult obesity, gut health and disease and mental health. We also discuss how the food industry uses refined sugars to create pseudo foods and what these do to the brain and body. This episode is replete with actionable information about sugar and metabolism, weight control, brain health and body composition. It ought to be of interest to anyone seeking to understand how specific food choices impact the immediate and long-term health of the brain and body. For the show notes, including referenced articles and additional resources, please visit https://www.hubermanlab.com/episode/dr-robert-lustig-how-sug…our-health Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Levels: https://levels.link/huberman AeroPress: https://aeropress.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Robert Lustig Website: https://robertlustig.com Books: https://robertlustig.com/books Publications: https://robertlustig.com/publications Blog: https://robertlustig.com/blog UCSF academic profile: https://profiles.ucsf.edu/robert.lustig Metabolical (book): https://amzn.to/48mNhOE SugarScience: http://sugarscience.ucsf.edu X: https://twitter.com/RobertLustigMD Facebook: https://www.facebook.com/DrRobertLustig LinkedIn: https://www.linkedin.com/in/robert-lustig-8904245 Instagram: https://www.instagram.com/robertlustigmd Threads: https://www.threads.net/@robertlustigmd Timestamps 00:00:00 Dr. Robert Lustig 00:02:02 Sponsors: Eight Sleep, Levels & AeroPress 00:06:41 Calories, Fiber 00:12:15 Calories, Protein & Fat, Trans Fats 00:18:23 Carbohydrate Calories, Glucose vs. Fructose, Fruit, Processed Foods 00:26:43 Fructose, Mitochondria & Metabolic Health 00:31:54 Trans Fats; Food Industry & Language 00:35:33 Sponsor: AG1 00:37:04 Glucose, Insulin, Muscle 00:42:31 Insulin & Cell Growth vs. Burn; Oxygen & Cell Growth, Cancer 00:51:14 Glucose vs. Fructose, Uric Acid; “Leaky Gut” & Inflammation 01:00:51 Supporting the Gut Microbiome, Fasting 01:04:13 Highly Processed Foods, Sugars; “Price Elasticity” & Food Industry 01:10:28 Sponsor: LMNT 01:11:51 Processed Foods & Added Sugars 01:14:19 Sugars, High-Fructose Corn Syrup 01:18:16 Food Industry & Added Sugar, Personal Responsibility, Public Health 01:30:04 Obesity, Diabetes, “Hidden” Sugars 01:34:57 Diet, Insulin & Sugars 01:38:20 Tools: NOVA Food Classification; Perfact Recommendations 01:43:46 Meat & Metabolic Health, Eggs, Fish 01:46:44 Sources of Omega-3s; Vitamin C & Vitamin D 01:52:37 Tool: Reduce Inflammation; Sugars, Cortisol & Stress 01:59:12 Food Industry, Big Pharma & Government; Statins 02:06:55 Public Health Shifts, Rebellion, Sugar Tax, Hidden Sugars 02:12:58 Real Food Movement, Public School Lunches & Processed Foods 02:18:25 3 Fat Types & Metabolic Health; Sugar, Alcohol & Stress 02:26:40 Artificial & Non-Caloric Sweeteners, Insulin & Weight Gain 02:34:32 Re-Engineering Ultra-Processed Food 02:38:45 Sugar & Addiction, Caffeine 02:45:18 GLP-1, Semaglutide (Ozempic, Wegovy, Tirzepatide), Risks; Big Pharma 02:57:39 Obesity & Sugar Addiction; Brain Re-Mapping, Insulin & Leptin Resistance 03:03:31 Fructose & Addiction, Personal Responsibility & Tobacco 03:07:27 Food Choices: Fruit, Rice, Tomato Sauce, Bread, Meats, Fermented Foods 03:12:54 Intermittent Fasting, Diet Soda, Food Combinations, Fiber, Food Labels 03:19:14 Improving Health, Advocacy, School Lunches, Hidden Sugars 03:26:55 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter #HubermanLab #Science #Nutrition Title Card Photo Credit: Mike Blabac — https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer
In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don’t Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. #HubermanLab #DavidSinclair #Longevity
A new study in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University of Washington School of Medicine used software to create protein molecules that bind with exceptionally high affinity and specificity to a variety of challenging biomarkers, including human hormones.
Notably, the scientists achieved the highest interaction strength ever reported between a computer-generated biomolecule and its target.
Senior author David Baker, professor of biochemistry at UW Medicine and Howard Hughes Medical Institute investigator, emphasized the potential impact: “The ability to generate novel proteins with such high binding affinity and specificity opens up a world of possibilities, from new disease treatments to advanced diagnostics.”
