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Peppermint oil plasma coating could cut catheter infections without releasing drugs

Australian researchers have developed a high‑performance coating made from peppermint essential oil that can be applied to the surfaces of many commonly used medical devices, offering a safer way to protect patients from infection and inflammation.

Matthew Flinders Professor and senior author of the new study, Professor Krasimir Vasilev, says the idea emerged after noticing that eating peppermint leaves from his drink significantly relieved his sore throat, inspiring him to explore whether its bioactivity could be converted into a durable coating using plasma technology—something he has been researching for more than two decades.

The team from Flinders’s Biomedical Nanoengineering Laboratory—including Professor Vasilev (Director), Associate Professor Vi‑Khanh Truong, Dr. Andrew Hayes, and Ph.D. candidates Trong Quan Luu and Tuyet Pham—created a nanoscale peppermint‑oil coating that protects against infection, inflammation and oxidative stress, while remaining compatible with human tissue and suitable for medical materials.

Joscha Bach presents “Machine Consciousness and Beyond” | dAGI Summit 2025

Bach reframes AI as the endpoint of a long philosophical project to “naturalize the mind,” arguing that modern machine learning operationalizes a lineage from Aristotle to Turing in which minds, worlds, and representations are computational state-transition systems. He claims computer science effectively re-discovers animism—software as self-organizing, energ†y-harvesting “spirits”—and that consciousness is a simple coherence-maximizing operator required for self-organizing agents rather than a metaphysical mystery. Current LLMs only simulate phenomenology using deepfaked human texts, but the universality of learning systems suggests that, when trained on the right structures, artificial models could converge toward the same internal causal patterns that give rise to consciousness. Bach proposes a biological-to-machine consciousness framework and a research program (CIMC) to formalize, test, and potentially reproduce such mechanisms, arguing that understanding consciousness is essential for culture, ethics, and future coexistence with artificial minds.

Key takeaways.

▸ Speaker & lens: Cognitive scientist and AI theorist aiming to unify philosophy of mind, computer science, and modern ML into a single computationalist worldview.
▸ AI as philosophical project: Modern AI fulfills the ancient ambition to map mind into mathematics; computation provides the only consistent language for modeling reality and experience.
▸ Computationalist functionalism: Objects = state-transition functions; representations = executable models; syntax = semantics in constructive systems.
▸ Cyber-animism: Software as “spirits”—self-organizing, adaptive control processes; living systems differ from dead ones by the software they run.
▸ Consciousness as function: A coherence-maximizing operator that integrates mental states; second-order perception that stabilizes working memory; emerges early in development as a prerequisite for learning.
▸ LLMs & phenomenology: Current models aren’t conscious; they simulate discourse about consciousness using data full of “deepfaked” phenomenology. A Turing test cannot detect consciousness because performance ≠ mechanism.
▸ Universality hypothesis: Different architectures optimized for the same task tend to converge on similar internal causal structures; suggests that consciousness-like organization could arise if it’s the simplest solution to coherence and control.
▸ Philosophical zombies: Behaviorally identical but non-conscious agents may be more complex than conscious ones; evolution chooses simplicity → consciousness may be the minimal solution for self-organized intelligence.
▸ Language vs embodiment: Language may contain enough statistical structure to reconstruct much of reality; embodiment may not be strictly necessary for convergent world models.
▸ Testing for machine consciousness: Requires specifying phenomenology, function, search space, and success criteria—not performance metrics.
▸ CIMC agenda: Build frameworks and experiments to recreate consciousness-like operators in machines; explore implications for ethics, interfaces, and coexistence with future minds.

Mars Base

To become an Interplanetary Species we need to colonize another planet, and Mars will be our first target. To establish a base there, and a future settlement, we need to get their first, so we will also examine the Aldrin Cycler, a type of spacecraft that may make traveling to other worlds far easier.

Visit our sponsor, Brilliant: https://brilliant.org/IsaacArthur/

National Space Society Roadmap:
https://space.nss.org/nss-roadmap-to–… this channel to get access to perks: / @isaacarthursfia Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord version: / mars-base-narration-only Credits: Becoming an Interplanetary Species: Mars Base Science & Futurism with Isaac Arthur Episode 261; October 22, 2020 Written, Produced & Narrated by Isaac Arthur Written by: Isaac Arthur Editors: Jerry Guern Keith Blockus Matthew Acker Cover Art: Jakub Grygier https://www.artstation.com/jakub_grygier Graphics: Jeremy Jozwik https://www.artstation.com/zeuxis_of_… Sam McNamara Sergio Botero https://www.artstation.com/sboterod?f… Tristan 3D Music Sergey Cheremisninov, “Sirius” https://www.s-cheremisinov.com Reign Pagaran, “Distant Voyager” Aerium, “Fifth Star of Aldebaran” / @officialaerium Denny Schneidemesser, “Across the Universe” & “Luminous Rays” / denny-schneidemesser.
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Credits:
Becoming an Interplanetary Species: Mars Base.
Science & Futurism with Isaac Arthur.
Episode 261; October 22, 2020
Written, Produced & Narrated by Isaac Arthur.

Written by:
Isaac Arthur.

Editors:

Sentience Beyond Biology — Debate w/Dmitry Volkov, Joscha Bach, Matthew MacDougall, Murray Shanahan

What happens when biology is no longer the foundation for sentience, agency, and consciousness?

This groundbreaking panel discussion brings together some of the world’s most brilliant minds in AI, neuroscience, and philosophy to tackle humanity’s most profound questions about the future of intelligence.

Chaired by neuroscientist Patrick House, the conversation explores the boundaries of machine agency, the possibility of AI emotion, and the future of human–machine interaction.

🎙 Featured Speakers:
- Joscha Bach – Cognitive Scientist, AI Researcher, Philosopher.
- Dmitry Volkov – Co-founder of the International Center for Consciousness Studies (ICCS), Philosopher, Entrepreneur, Founder of Social Discovery Group & EVA AI
- Matthew Macdougall – Head of Surgery at Neuralink, Pioneer in Brain–Computer Interfaces.
- Murray Shanahan – Professor of Cognitive Robotics at Imperial College London, Scientist at DeepMind.

Key Topics in This Debate:
- Whether giving machines “agency” is just a useful human shortcut (The Intentional Stance).
- If the deeper question is not “Is AI conscious?” but “Can it truly love?”
- How modern AI is erasing the Uncanny Valley.
- The challenge of true individuality and creativity in AI-generated art.
- How human biological hardware shapes consciousness — and what this means for building sentient machines.

00:00:00 — Introduction and Presentation of Participants.

Sri Newsletter — “We Speak For The Settlers!”

Space Renaissance International (SRI) is a Permanent Observer at the UN’s Committee on the Peaceful Uses of Outer Space (COPUOS). We are currently advocating for: Ownership of resources removed from in place (being considered by the COPUOS Working Group on the Legal Aspects of Space Resource Activity); Permanent advisory status for the private sector in Read More

Hypoperfusion on Early MRI Despite Successful Thrombectomy: A Prospective Imaging and Inflammatory Biomarkers Study

ISC26 After successful EVT for stroke, early MRI shows residual hypoperfusion in a substantial subset of patients. Perfusion deficits mainly reflected distal emboli and were not associated with inflammatory biomarkers.


In acute ischemic stroke (AIS) due to large-vessel occlusion (LVO), endovascular treatment (EVT) achieves over 80% recanalization rates and improves functional outcomes.1 However, nearly half of recanalized patients fail to achieve functional independence,1 a phenomenon termed futile recanalization.2,3 Mechanisms of futile recanalization include early extensive infarct core—that is, tissue that is already irreversibly damaged at the time of reperfusion—as well as edema, hemorrhagic transformation, and no-reflow.3 The latter, defined as impaired capillary reperfusion despite angiographic success, has gained increasing attention.4–15

In experimental models, no-reflow occurs early after arterial reopening and is driven by multifactorial microvascular dysfunction.16–19 Reported mechanisms include astrocyte and endothelial swelling, pericyte contraction, leukocytes, platelets and erythrocytes aggregation, and the release of inflammatory mediators.20–24 Regarding the latter, cytokines and adhesion molecules have been implicated in its pathogenesis in preclinical studies.24 These findings have led to the hypothesis that inflammation may contribute to microvascular perfusion failure after EVT, potentially opening the door to targeted therapeutic interventions.20–24 However, this has never been systematically investigated in humans.

In clinical practice, persistent hypoperfusion on post-EVT computed tomography (CT) perfusion or magnetic resonance perfusion imaging is frequently interpreted as a radiological correlate of no-reflow.4–15 Yet this interpretation remains uncertain. First, no direct histological evidence of no-reflow has been demonstrated in human stroke to date. Second, most imaging-based studies on no-reflow have included patients with residual distal emboli,10,12,25 which cause residual hypoperfusion on a macrovascular level.26 Third, many studies did not exclude confounders, such as perfusion abnormalities caused by carotid stenosis, parenchymal hemorrhage, or reocclusion.14 These limitations may explain the wide variability in the reported prevalence of postthrombectomy hypoperfusion, from 0% to 80%.14,25.

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