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New research shows that nasal drops of neuropeptide Y triggers extinction of fear memories in an animal model of PTSD.

We conducted a multicenter, nested case–control study of Alzheimer’s disease biomarkers in cognitively normal participants who were enrolled in the China Cognition and Aging Study from January 2000 through December 2020. A subgroup of these participants underwent testing of cerebrospinal fluid (CSF), cognitive assessments, and brain imaging at 2-year–to–3-year intervals. A total of 648 participants in whom Alzheimer’s disease developed were matched with 648 participants who had normal cognition, and the temporal trajectories of CSF biochemical marker concentrations, cognitive testing, and imaging were analyzed in the two groups.

The median follow-up was 19.9 years (interquartile range, 19.5 to 20.2). CSF and imaging biomarkers in the Alzheimer’s disease group diverged from those in the cognitively normal group at the following estimated number of years before diagnosis: amyloid-beta (Aβ)₄₂, 18 years; the ratio of Aβ₄₂ to Aβ₄₀, 14 years; phosphorylated tau 181, 11 years; total tau, 10 years; neurofilament light chain, 9 years; hippocampal volume, 8 years; and cognitive decline, 6 years. As cognitive impairment progressed, the changes in CSF biomarker levels in the Alzheimer’s disease group initially accelerated and then slowed.

In this study involving Chinese participants during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease, we observed the time courses of CSF biomarkers, the times before diagnosis at which they diverged from the biomarkers from a matched group of participants who remained cognitively normal, and the temporal order in which the biomarkers became abnormal. (Funded by the Key Project of the National Natural Science Foundation of China and others; ClinicalTrials.gov number, NCT03653156. opens in new tab.)

“A New York City medical school will offer students free tuition following a $1bn donation from the 93-year-old widow of a major Wall Street investor.”

The record-breaking donation came from a 93-year-old former professor, who is the widow of a wealthy investor.

Scientists can now 3D print more-realistic prosthetic eyes in a fraction of the time and effort required by traditional approaches.

The property is currently an observatory surrounded by open land. System officials say they’ll use it for agricultural research and other opportunities.

The International Astronomical Union has confirmed the existence of three currently unnamed moons — one around Uranus and two orbiting Neptune.

Important lessons from the Big Tech CEO of the hour.

Joe Louca: “Think of it like a realistic video game set on the Moon – we want to make sure the virtual version of moon dust behaves just like the actual thing, so that if we are using it to control a robot on the Moon, then it will behave as we expect.”

After Neil Armstrong took his first steps on the Moon, he said, “It’s almost like a powder”, as he described the lunar regolith, and astronauts on future Apollo missions found working on the lunar surface rather cumbersome and tedious due to the much finer lunar dust compared to Earth’s dirt. Therefore, what steps can be taken to better prepare future rovers and astronauts for NASA’s Artemis program to work on the lunar surface?

This is what a recent study published in Frontiers in Space Technologies hopes to address as a team of researchers led by the University of Bristol developed virtual models of lunar regolith simulants that could provide cost-effective methods to prepare astronauts and robots to work on the lunar surface, someday.

Continue reading “Enhancing Lunar Exploration: Realistic Simulation of Moon Dust for Robot Operation” »

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