Lifeboat Foundation

Drug development is a huge component of healthcare research that continues to grow, however, about 90% of drugs generated fail to make it to clinical trials. Drugs designed to target cancer fail due to many different obstacles including the tumor microenvironment (TME), which is the area surrounding the tumor. The TME is comprised of multiple cells generated to suppress the immune system and allow the tumor to grow. Since there are many mechanisms involved that makeup the TME, it is difficult to prescribe patients anti-cancer drugs that completely kill the tumor. Often a combination therapies are needed, but doctors run the risk of adverse side effects in patients due to toxicity of too many drugs.

Recently, a study published in eLife from Dr. Jennifer Gerton at the Stowers Institute for Medical Research in Kansas City, Missouri reported one critical reason why patients may experience unexpected side effects on the cellular level.

SBUDNIC, built by an academically diverse team of students, was confirmed to have successfully reentered Earth’s atmosphere in August, demonstrating a practical, low-cost method to cut down on space debris.

When it comes to space satellites, getting the math wrong can be catastrophic for an object in orbit, potentially leading to its abrupt or fiery demise. In this case, however, the fiery end was cause for celebration.

About five years ahead of schedule, a small cube satellite designed and built by Brown University students to demonstrate a practical, low-cost method to cut down on space debris reentered Earth’s atmosphere sometime on Tuesday, Aug. 8 or immediately after—burning up high above Turkey after 445 days in orbit, according to its last tracked location from U.S. Space Command.

Flying robotic systems have already proved to be highly promising for tackling numerous real-world problems, including explorations of remote environments, the delivery of packages in inaccessible sites, and searches for survivors of natural disasters. In recent years, roboticists and computer scientists have introduced a multitude of aerial vehicle designs, each with distinct advantages and features.

Researchers at Sharif University of Technology in Iran recently carried out a study exploring the potential of flying robotic systems with a single wing, known as mono-wing aerial vehicles. Their paper, published in the Journal of Intelligent & Robotic Systems, outlines a new approach that could help to better control the flight of these vehicles as they navigate their surrounding environment.

“Unconventional vehicles inspired by natural phenomena consistently captivate the attention of engineers,” Afshin Banazadeh, one of the researchers who carried out the study, told Tech Xplore. “One such vehicle, the mono-wing, a single-bladed aerial vehicle, is no exception.

Research has brought clarity to the longstanding question of how starch granules form in the seeds of Triticeae crops—wheat, barley, and rye—unlocking diverse potential benefits for numerous industries and for human health.

Starch in wheat, maize, rice and potatoes is a vital energy-giving part of our diet and a key ingredient in many industrial applications from brewing and baking to the production of paper, glue, textiles, and construction materials.

Starch granules of different crops vary greatly in size and shape. Wheat starch (and those of other Triticeae) uniquely have two distinct types of granules: large A-type granules and smaller B-type granules.

Fascinating discussion of how biotech companies (esp. Paratus) and academic researchers are leveraging the unique immunobiology of bats to find new ways of treating inflammation, cancer, infections, metabolic diseases, and more. Exploration through comparative genomic approaches as well as newly created bat iPSCs is yielding mechanistic discoveries that could inform the medicines of tomorrow. #biotech #molecularbiology #genomics #stemcells

Harnessing the unusual biology of bats, researchers aim to turn drug discovery upside-down.

Part of the Large Hadron Collider’s Compact Muon Solenoid detector. (CERN) A mysterious particle thought to have existed briefly just after the Big Bang has now been detected for the first time in the ‘primordial soup’.

This study has successfully developed a high-efficiency neutron detector array with an exceptionally low background to measure the cross-section of the 13C(α, n)16O reaction at the China Jinping Underground Laboratory (CJPL). Comprising 24 3He proportional counters embedded in a polyethylene moderator, and shielded with 7% borated polyethylene layer, the neutron background at CJPL was as low as 4.5 counts/h, whereby 1.94 counts/h was attributed to the internal α radioactivity. Remarkably, the angular distribution of the 13C(α, n)16O reaction was proven to be a primary variable affecting the detection efficiency. The detection efficiency of the array for neutrons in the range of 0.1MeV to 4.5 MeV was determined using the 51V(p, n)51Cr reaction carried out with the 3 MV tandem accelerator at Sichuan University and Monte Carlo simulations. Future studies can be planned to focus on further improvement of the efficiency accuracy by measuring the angular distribution of 13C(α, n)16O reaction.

Gamow window is the range of energies which defines the optimal energy for reactions at a given temperature in stars. The nuclear cross-section of a nucleus is used to describe the probability that a nuclear reaction will occur. The 13C(α, n)16O reaction is the main neutron source for the slow neutron capture process (s-process) in asymptotic giant branch (AGB) stars, in which the 13C(α, n)16O reaction occurs at the Gamow window spanning from 150 to 230 keV. Hence, it is necessary to precisely measure the cross-section of 13C(α, n)16O reaction in this energy range. A low-background and high detection efficiency neutron detector is the essential equipment to carry out such measurements. This study developed a low-background neutron detector array that exhibited high detection efficiency to address the demands. With such development, advanced studies, including direct cross-section measurements of the key neutron source reactions in stars, can be conducted in the near future.

Low-background neutron detectors play a crucial role in facilitating research related to nuclear astrophysics, neutrino physics, and dark matter. By improving the efficiency and upgrading the technological capability of low background neutron detectors, this study indirectly contributes to the enhancement of scientific research. Additionally, fields involving material science and nuclear reactor technology would also benefit from the perfection of neutron detector technology. Taking into consideration the potential application and expansion of these findings, such innovative attempt aligns well with UNSDG9: Industry, Innovation & Infrastructure.

Monash University researchers have uncovered why some intestinal worm infections become chronic in animal models, which could eventually lead to human vaccines and improved treatments.

Parasitic worms, also called helminths, usually infect the host by living in the gut. About a quarter of the world population is afflicted with helminth infections.

They are highly prevalent in developing countries such as sub-Saharan Africa, South America and some tropical countries in Asia. In Australia, they can be a problem in First Nations communities.

One of the most promising developments in the fight against cybersecurity threats is the use of artificial intelligence (AI). This cutting-edge technology has the potential to revolutionize the way organizations manage cyberthreats, offering unprecedented levels of protection and adaptability. AI is set to be embedded into every security product, enabling organizations to quickly remediate attacks and stay ahead of the threat landscape. However, bad actors are equally interested in unlocking the power of AI to easily launch sophisticated and targeted attacks.

The convergence of AI and cybersecurity will create opportunities and challenges for organizations. In this blog post, we will delve into the transformative impact that AI will have on cybersecurity, explore its potential to empower organizations to stay ahead of threats, and examine the ways bad actors could use it for their own nefarious purposes.

By harnessing the power of AI while remaining vigilant to its potential misuse, organizations can stay ahead of emerging threats and better protect their valuable applications, APIs, and data.