Lifeboat Foundation

Following your gut. Losing your appetite. A gutsy move. Though we often consider the gut as merely a digestive tool, these common expressions reflect the central role the gut plays in a much wider range of essential functions.

The entire digestive tract is lined by the enteric nervous system (ENS), a vast network of millions of neurons and glial cells—the two primary cell types also found in the central nervous system. While often called the second brain, the ENS not only generates the same neurotransmitters but actually predates the evolution of the central nervous system in the brain.

The functions of the ENS are crucial to life and extend far beyond digestion, as it regulates immunity, gut secretions, and enables complex, bi-directional communication between the gut and the brain. This is why a happy gut co-exists with a happy brain, and why digestive issues can lead to changes in mood and behavior.

Most children receiving radiation therapy for cancer can hold still without anesthesia if they watch videos during the treatment, a study of a technique developed at Stanford Medicine found.

Scientists investigating the possible health effects of microplastics have uncovered some disturbing initial results in an experiment based on mice.

When old and young rodents drank microscopic fragments of plastic suspended in their water over the course of three weeks, researchers at the University of Rhode Island found traces of the pollutants had accumulated in every organ of the tiny mammal’s body, including the brain.

The presence of these microplastics was also accompanied by behavioral changes akin to dementia in humans, as well as changes to immune markers in the liver and brain.

A machine-learning algorithm demonstrated the capability to process data that exceeds a computer’s available memory by identifying a massive data set’s key features and dividing them into manageable batches that don’t choke computer hardware. Developed at Los Alamos National Laboratory, the algorithm set a world record for factorizing huge data sets during a test run on Oak Ridge National Laboratory’s Summit, the world’s fifth-fastest supercomputer.

Equally efficient on laptops and supercomputers, the highly scalable algorithm solves hardware bottlenecks that prevent processing information from data-rich applications in cancer research, satellite imagery, social media networks, national security science and earthquake research, to name just a few.

“We developed an ‘out-of-memory’ implementation of the non-negative matrix factorization method that allows you to factorize larger data sets than previously possible on a given hardware,” said Ismael Boureima, a computational physicist at Los Alamos National Laboratory. Boureima is first author of the paper in The Journal of Supercomputing on the record-breaking algorithm.

Besides recognizing cancer signatures, liquid biopsy technologies are informing treatment decisions and predicting patient outcomes.

Congestive heart failure (also called heart failure) is a serious condition in which the heart doesn’t pump blood as efficiently as it should. Despite its name, heart failure doesn’t mean that the heart has literally failed or is about to stop working. Rather, it means that the heart muscle has become less able to contract over time or has a mechanical problem that limits its ability to fill with blood. As a result, it can’t keep up with the body’s demand, and blood returns to the heart faster than it can be pumped out—it becomes congested, or backed up. This pumping problem means that not enough oxygen-rich blood can get to the body’s other organs.

The body tries to compensate in different ways. The heart beats faster to take less time for refilling after it contracts—but over the long run, less blood circulates, and the extra effort can cause heart palpitations. The heart also enlarges a bit to make room for the blood. The lungs fill with fluid, causing shortness of breath. The kidneys, when they don’t receive enough blood, begin to retain water and sodium, which can lead to kidney failure. With or without treatment, heart failure is often and typically progressive, meaning it gradually gets worse.

More than 5 million people in the United States have congestive heart failure. It’s the most common diagnosis in hospitalized patients over age 65. One in nine deaths has heart failure as a contributing cause.

We don’t treat Isla’s vision loss as a sad circumstance or as something that is broken in her. It’s so important for us that she knows her vision impairment is not something that makes her less than. If anything, it makes her a stronger, more amazing person, and we couldn’t be prouder of who she is.

Vision impairment is the only symptom she displays of this disease, and we are fighting with everything we have to ensure it stays this way. We were told on diagnosis day that that day was the healthiest Isla would ever be, and that she was at her peak; two years later, and she has continued to defy that, Stockdale added.

The family believes that Isla’s incredible development is a result of the medication, called Miglustat, which she has been taking since November 2022.

In the study, published today in Science Translational Medicine, the researchers used engineered CAR T cells to target CD45—a surface marker found on nearly all blood cells, including nearly all blood cancer cells. Because CD45 is found on healthy blood cells too, the research team used CRISPR base-editing to develop a method called “epitope editing” to overcome the challenges of an anti-CD45 strategy, which would otherwise result in low blood counts, with potentially life-threating side effects. The early results represent a proof-of-concept for epitope editing, which involves changing a small piece of the target CD45 molecule just enough so that the CAR T cells don’t recognize it, but it… More.

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. A new preclinical, proof-of-concept study details the “epitope-editing” approach.

PHILADELPHIA—Trying to finish your homework while the big game is on TV? “Visual-movement” neurons in the front of your brain can help you stay focused, according to a new study from neuroscientists in the Perelman School of Medicine at the University of Pennsylvania.

In the study, published recently in Neuron, the scientists sought to illuminate the neural mechanism that helps the brain decide whether to focus visual attention on a rewarding task or an alluring distraction. By analyzing neuron activity in animal models as they faced this kind of attentional conflict, the researchers discovered that a pattern of coordinated activity called “beta bursts” in a set of neurons in the lateral prefrontal cortex (LPFC)—a section in the front of the brain responsible for motivation and rewards—appears to have a major role in keeping attention task-focused, essentially by suppressing the influence of the distracting stimulus.

“Our research suggests that while all brains have the ability to focus on a rewarding task and filter out distractions, some are better at it than others,” said senior author Bijan Pesaran PhD, the Robert A Groff II Professor of Neurosurgery at Penn Medicine. “By understanding how our brains process rewarding stimuli, we hope to be able to also understand failures to do so in a variety of cognitive and psychiatric disorders, including attention deficit disorder, schizophrenia, and obsessive-compulsive disorder.”