Now online! Leigh syndrome is a severe and untreatable mitochondrial disease. Using patient-derived models in 2D and 3D, Zink and colleagues identify the PDE5 inhibitor sildenafil as a repurposable drug candidate, leading to lifespan extension in mammalian models and clinical improvement in six individuals with Leigh syndrome.
In the wake of the worldwide increase in type-2 diabetes, a major focus of research is understanding the signaling pathways impacting this disease. Insulin signaling regulates glucose, lipid, and energy homeostasis, predominantly via action on liver, skeletal muscle, and adipose tissue. Precise modulation of this pathway is vital for adaption as the individual moves from the fed to the fasted state. The positive and negative modulators acting on different steps of the signaling pathway, as well as the diversity of protein isoform interaction, ensure a proper and coordinated biological response to insulin in different tissues. Whereas genetic mutations are causes of rare and severe insulin resistance, obesity can lead to insulin resistance through a variety of mechanisms.
Zhang, S., Fu, Q., Yuan, X. et al. Reshaping the colorectal cancer immune microenvironment: insights from single-cell and spatial omics. Cancer Cell Int (2026). https://doi.org/10.1186/s12935-026-04245-y.
New in practicalRO: radonc.
A dose-escalation trial of reirradiation (reRT) was conducted in patients with a diagnosis of recurrent glioblastoma (rGBM) to increase the total overall dose given to the tumor without increasing toxicity. The primary objective of this study was to establish the maximum tolerated dose (MTD) for reRT in patients with rGBM.
A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer developed.
The research, published in Science, was led by physician-scientists in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center. It’s the first time scientists have shown that a medical intervention could stop growth of pre-cancerous lesions in the pancreas before they develop into pancreatic cancer, providing strong evidence for the burgeoning field of cancer interception.
“I’m convinced that cancer interception will become the next frontier of cancer therapy,” said co-corresponding author Robert Vonderheide, MD, DPhil, director of the Abramson Cancer Center.
PGT-SR reveals that even small pericentric and paracentric inversions carry a small but measurable reproductive risk, challenging assumptions of minimal impact in IVF outcomes.
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How does the short-term care burden compare between heart transplants and LVADs? LVADs have higher upfront costs and longer stays; heart transplant recipients incur greater rehospitalization costs over time. @mogga72553 @HartfordHealthC
BackgroundHeart transplant (HT) and left ventricular assist devices (LVADs) are treatment options for advanced heart failure refractory to standard therapy. Historically, LVADs have been used as either destination therapy or a bridge to transplant. However, recent changes to the organ allocation system have deprioritized patients on LVADs as transplant recipients, leading to divisive views on the role of an LVAD. The comparative short‐term care burden with each modality remains unclear.
Researchers have developed a technology to invisibly transmit information disguised as background thermal radiation. Using a phenomenon called “negative light,” they transferred 100 kilobits of data per second in a way that was completely undetectable to outside observers.
Most methods for concealing data during transfer involve hiding it among other data or encrypting it in a way that makes it impossible to read without a cipher or other means of decryption. The new technique, by contrast, makes the data almost impossible to intercept because there’s no indication it’s being sent at all. It can also be encrypted through traditional means to further harden security, the team wrote in a paper published March 5 in the journal Light: Science & Applications.