Durable remission was achieved with front-line dasatinib plus blinatumomab in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia.
NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary.
A research team led by the Paul Scherrer Institute has spectroscopically observed the fractionalization of electronic charge in an iron-based metallic ferromagnet. Experimental observation of the phenomenon is not only of fundamental importance. Since it appears in an alloy of common metals at accessible temperatures, it holds potential for future exploitation in electronic devices. The discovery is published in the journal Nature.
Basic quantum mechanics tells us that the fundamental unit of charge is unbreakable: the electron charge is quantized. Yet, we have come to understand that exceptions exist. In some situations, electrons arrange themselves collectively as if they were split into independent entities, each possessing a fraction of the charge.
The fact that charge can be fractionalized is not new: it has been observed experimentally since the early 1980s with the Fractional Quantum Hall Effect. In this, the conductance of a system in which electrons are confined to a two-dimensional plane is observed to be quantized in fractional—rather than integer—units of charge.
Scientists have revealed surprising parallels between aging and schizophrenia. There seem to be similar patterns of gene activity in the brains of people who are aging, and in those with schizophrenia. The same mechanisms may underlie the cognitive disruptions seen in older adults and people with schizophrenia. The findings have been reported in Nature.
In this work, the researchers analyzed gene expression at the single-cell level in post-mortem brain samples from 94 people with schizophrenia and 97 unaffected individuals. This gene activity was altered in two types of cells found in the brain, both neurons and astrocytes. In all, 1.2 million cells from were analyzed. This showed that in neurons, expression changed in genes that are associated with portions of synapses, the space where neurons meet and communicate; and in astrocytes, in genes that are related to synaptic function.
For decades, scientists and pathologists have tried, without much success, to come up with a way to determine which individual lung cancer patients are at greatest risk of having their illness spread, or metastasize, to other parts of the body.
Now a team of scientists from Caltech and the Washington University School of Medicine in St. Louis has fed that problem to artificial intelligence (AI) algorithms, asking computers to predict which cancer cases are likely to metastasize. In a novel pilot study of non-small cell lung cancer (NSCLC) patients, AI outperformed expert pathologists in making such predictions.
These predictions about the progression of lung cancer have important implications in terms of an individual patient’s life. Physicians treating early-stage NSCLC patients face the extremely difficult decision of whether to intervene with expensive, toxic treatments, such as chemotherapy or radiation, after a patient undergoes lung surgery. In some ways, this is the more cautious path because more than half of stage I–III NSCLC patients eventually experience metastasis to the brain. But that means many others do not. For those patients, such difficult treatments are wholly unnecessary.
Colchicine reduced cardiovascular events in patients with diabetes and recent myocardial infarction in a randomized study.
NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary.
A Tufts School of Medicine researcher is developing a test to predict lung cancer risk more accurately and reduce the number of scans to detect the condition.
Dr Freese has also made the case for a Dark Big Bang that could have given rise to dark matter independently of normal matter in the days after the Big Bang. The traditional model of the universe says that matter and dark matter were produced at the same time. The earliest evidence of dark matter, however, only appears later in the early evolution of the universe, when cosmic structure starts to form.
One explanation for this is that matter and dark matter did not, in fact, appear together, but that dark matter entered the universe in a second cataclysmic release of energy from the vacuum—the Dark Big Bang—as much as a month after the traditional Big Bang. The model that Dr Freese and her co-author Martin Winkler explored would explain why dark matter might be completely decoupled from traditional matter and it also naturally produces SIDM candidates. If there was such a Dark Big Bang, it would have left a clear signature—a pattern in the frequencies of the gravitational waves that hum across the universe—that could be picked up by future gravitational-wave detectors.
Cancer cells are characterized by their aggressiveness: they grow rapidly and spread to other parts of the body. To enable this, numerous mechanisms come into play, and one of them involves a protein called MYC, which activates certain genes on the cancer cell’s DNA strand, causing the cancer cell to grow and divide.
The MYC protein is also present in healthy individuals, where it plays a crucial role in regulating many cell functions.
“When cancer occurs, it is due to an accumulation of mutations in our DNA, often resulting in the overactivation of the MYC protein. Therefore, this protein plays a crucial role in most cancer forms,” says Rasmus Siersbæk, head of research at the Department of Biochemistry and Molecular Biology, University of Southern Denmark.
With a mobile app powered by artificial intelligence (AI), Caitlin Hicks, MD, MS, reviews selfies of patients’ feet in real time to track their wounds as part of a clinical trial. The app saves time for Hicks, a vascular surgeon at Johns Hopkins Medicine, but also reduces clinic trips for her patients with diabetes in inner-city Baltimore, many of whom are elderly and less mobile or have other socioeconomic barriers to care. Hicks knows that for these patients, wound vigilance is the linchpin to preventing infection, hospitalization, or, worse, amputation or even death.
Despite their crushing toll, diabetic foot infections remain stubbornly hard to treat, but multidisciplinary care teams, new drugs and devices on the horizon, and practical solutions to socioeconomic factors could budge the needle.
