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Aug 25, 2023

Paralysis can rob people of their ability to speak. Now researchers hope to give it back

Posted by in categories: biotech/medical, computing, neuroscience

That early experience drove his professional interest in helping people communicate.

Now, Henderson’s an author on one of two papers published Wednesday showing substantial advances toward enabling speech in people injured by stroke, accident or disease.

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Aug 25, 2023

Cancer’s origin story features predictable plot line, Stanford Medicine researchers find

Posted by in categories: biotech/medical, genetics

Human cells evolving in the laboratory undergo a series of predictable, sequential genetic changes that lead to pre-cancer. Blocking these changes may allow intervention before cancer occurs.

Aug 25, 2023

Screening during IVF for inherited diseases greatly reduces costs of care

Posted by in categories: biotech/medical, genetics, health

For prospective parents who are carriers of many inherited diseases, using in vitro fertilization along with genetic testing would significantly lower health care expenditures, according to researchers at Stanford Medicine.

Preimplantation genetic diagnostic testing during IVF, or PGD-IVF, is being used to screen for single-gene defect conditions such as cystic fibrosis, sickle cell disease and Tay-Sachs disease, along with nearly 400 others.

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Aug 25, 2023

ChatGPT Still Needs Humans

Posted by in categories: employment, existential risks, robotics/AI

The media frenzy surrounding ChatGPT and other large, language model, artificial intelligence systems spans a range of themes, from the prosaic – large language models could replace conventional web search – to the concerning – AI will eliminate many jobs – and the overwrought – AI poses an extinction-level threat to humanity. All of these themes have a common denominator: large language models herald artificial intelligence that will supersede humanity.

But large language models, for all their complexity, are actually really dumb. And despite the name “artificial intelligence,” they’re completely dependent on human knowledge and labor. They can’t reliably generate new knowledge, of course, but there’s more to it than that.

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Aug 25, 2023

Common hormone could hold key to treating endometrial cancer

Posted by in category: biotech/medical

New research from QIMR Berghofer has found that the hormone testosterone may play an important role in the development of endometrial cancer.

The discovery raises exciting new possibilities for screening, preventing and fighting this increasingly prevalent disease.

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Aug 25, 2023

Novel chamber created to find carbon-free ways to keep people cool

Posted by in category: futurism

It could help researchers and builders find better ways to keep people cool in extreme temperatures.

Aug 25, 2023

How mRNA Could Safely Replace Blood Stem Cell Transplantation

Posted by in categories: biotech/medical, chemistry, genetics, life extension

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.

Aug 25, 2023

Naked Mole Rats’ Longevity Gene Successfully Transferred to Mice

Posted by in categories: biotech/medical, life extension

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

Aug 25, 2023

Artificial Intelligence & The Singularity — Dr. Ben Goertzel

Posted by in categories: robotics/AI, singularity

https://www.youtube.com/watch?v=SMNqLV17qJQ

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Dr Ben Goertzel is a cross-disciplinary scientist, futurist, author and entrepreneur, who has spent the best part of his working life focused on creating benevolent superhuman artificial general intelligence (AGI).

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Aug 25, 2023

What is life like elsewhere in the Universe?

Posted by in category: futurism

Whether or not life exists elsewhere in the Universe, we can be assured of one thing: We are the only human beings in the cosmos.