Lifeboat Foundation

It could help researchers and builders find better ways to keep people cool in extreme temperatures.

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

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Dr Ben Goertzel is a cross-disciplinary scientist, futurist, author and entrepreneur, who has spent the best part of his working life focused on creating benevolent superhuman artificial general intelligence (AGI).

Continue reading “Artificial Intelligence & The Singularity — Dr. Ben Goertzel” »

Whether or not life exists elsewhere in the Universe, we can be assured of one thing: We are the only human beings in the cosmos.

One of the most surrealist anc controversial science fiction writers.

We are living in strange times. Politics. Society. Culture wars. Things have gone weird. We’re looking for knowledge and wisdom to guide us in strange times.

Continue reading “The 9 prophetic visions of Philip K Dick” »

A team of geneticists and systems biologists at Stanford University has associated 169 genes that with the production of melanin in the skin, hair and eyes. In their study, reported in the journal Science, the group conducted a flow cytometry analysis and genome-wide CRISPR screen of cell samples.

Prior research has shown that the production and distribution of melanin in the body is responsible for skin tone, hair color and eye pigmentation. Such characteristics are important for more than appearance’s sake; skin with more melanin, for example, is better able to protect against ultraviolet radiation. In this new effort, the researchers noted that while many of the genes responsible for melanin production have been identified, many more have not.

The researchers began with an effort to differentiate high and low melanin melanocytes—the cells that make melanin. They used the light-reflecting properties of melanin to sort cells in a lab dish by aiming a fluorescent lamp at them. Once they had the cells sorted, they edited them using CRISPR-Cas9. Genes were systematically mutated to switch them off and then tested to see how well the cell continued to produce melanin.

India’s moon rover is now also on the moon, moving around and leaving its imprint on the soil, said a senior official of the Indian space agency.

“The rover rolled down onto the moon surface from the lander sometime around 12.30 a.m. Thursday. It is moving around. It is leaving its imprint on the moon’s surface,” Dr. S. Unnikrishnan Nair, Director, Vikram Sarabhai Space Centre (VSSC) told IANS.

The logo of Indian Space Research Organisation (ISRO) and the national emblem have been engraved on the wheels of the rover to leave the imprint when it moves around.

Scientists have created one of the most detailed 3D images of the synapse.

A synapse is a specialized junction between nerve cells that allows for the transfer of electrical or chemical signals, through the release of neurotransmitters by the presynaptic neuron and the binding of receptors on the postsynaptic neuron. It plays a key role in communication between neurons and in various physiological processes including perception, movement, and memory.