Lifeboat Foundation

Summary: The neuroscience of fitness explores how regular exercise profoundly impacts our brain and nervous system.

Exercise stimulates neurogenesis – the creation of new neurons – primarily in the hippocampus, influencing memory and learning while increasing key mood-regulating neurotransmitters. It also enhances brain plasticity, essential for recovery from injury and aging, and improves cognitive functions such as attention and memory.

Despite ongoing research, the current evidence underscores the powerful role of physical activity in promoting brain health and cognitive function, emphasizing the importance of integrating regular exercise into our lifestyles.

A new study in Nature hunted down another piece to the aging puzzle. In five species across the evolutionary scale—worms, flies, mice, rats, and humans—the team honed in on a critical molecular process that powers every single cell inside the body and degrades with age.

The process, called transcription, is the first step in turning our genetic material into proteins. Here, DNA letters are reworked into a “messenger” called RNA, which then shuttles the information to other parts of the cell to make proteins.

Scientists have long suspected that transcription may go awry with aging, but the new study offers proof that it doesn’t—with a twist. In all five of the species tested, as the organism grew older the process surprisingly sped up. But like trying to type faster when blindfolded, error rates also shot up.

Never heard of this fellow before but if you have a spare 50 minutes it’s a good listen. A summary of aging and what we might do about it with the goal (after about 26 minutes) of making an aging vaccine.

Lecture given by Dr. Ronjon Nag at “The Peter Wells Memorial Lecture 2023″ which took place in London on May 3rd, 2023.
https://events.theiet.org/events/the-peter-wells-memorial-lecture-2023/

Continue reading “Can We Live Longer than 120? Lecture” »

Researchers at Tufts University developed immortalized bovine muscle stem cells for cellular agriculture, potentially overcoming scaling challenges for meat production.

Andrew Stout, Tufts University.

Currently, it is difficult and expensive to produce cell-cultured meat because muscle and fat cells need to be able to grow and divide rapidly. Normal muscle stem cells can only divide about 50 times before they stop dividing and die. However, immortalized cells developed by the TUCCA team can divide indefinitely, which means they can produce much more meat.

Continue reading “Breakthrough in cellular agriculture, a game changer for cultured meat industry” »

Oldest known animal killed and secrets of immortality.

Ming the ocean quahog lived peacefully for over 500 years off the coast of Iceland. So why did a team of researchers dredge it up and kill it?

Discover the fascinating world of digital immortality and the pivotal role artificial intelligence plays in bringing this concept to life. In this captivating video, we delve into the intriguing idea of preserving our consciousness, memories, and personalities in a digital realm, potentially allowing us to live forever in a virtual environment. Unravel the cutting-edge AI technologies like mind uploading, AI-powered avatars, and advanced brain-computer interfaces that are pushing the boundaries of what it means to be alive.

Join us as we explore the ethical considerations, current progress, and future prospects of digital immortality. Learn about the ongoing advancements in brain-computer interfaces such as Neuralink, AI-powered virtual assistants like ChatGPT, and the challenges and opportunities that lie ahead. Will digital immortality redefine humanity’s relationship with life, death, and existence itself? Watch now to uncover the possibilities.

Continue reading “Digital Immortality Uncovered: How AI Could Help Us Live Forever” »

New research by biotech Integrated Biosciences and scientists from MIT and the Broad Institute of MIT and Harvard has demonstrated the potential of AI in discovering novel senolytic compounds.

Longevity. Technology: Senolytics are small molecules that suppress age-related processes such as fibrosis, inflammation and cancer. They target senescent cells – the so-called ‘zombie’ cells that are no longer dividing, emit toxic chemicals and are a hallmark of aging. Senescent cells have been linked to various age-related diseases, including cancer, cardiovascular disease, diabetes and Alzheimer’s disease, but senolytic compounds can tackle them by selectively inducing apoptosis or programmed cell death in these zombie cells. This new research reduced the number of senescent cells and lowered the expression of senescence-associated genes in aged mice, results which, the authors say “underscore the promise of leveraging deep learning to discover senotherapeutics” [1].

The AI-guided screening of more than 800,000 compounds led to the identification of three drug candidates, which, when compared with senolytics currently under investigation, were found to have comparable efficacy and superior medicinal chemistry properties [1].

Human lifespan is intricately connected to the aging process of individual cells, and this means that scientists have spent decades trying to unravel the mysteries of cellular aging and exploring methods to slow down the ticking of the aging clock.

Longevity. Technology: In 2020, a group of researchers from the University of California San Diego identified two distinct mechanisms of cellular aging and genetically manipulated them to extend cell lifespan [1]. Now, their research has progressed to employ synthetic biology and gene circuits to delay the deterioration associated with cellular aging [2]. The team’s innovative approach could revolutionize scientific methods of aging prevention and contribute to reprogramming aging pathways in various human cell types.

Publishing in Science, the researchers describe how cells in yeast, plants, animals and humans all contain gene regulatory circuits responsible for several physiological functions, including aging. These gene circuits, akin to electric circuits controlling household devices, can operate in different ways, and the UC San Diego team discovered that cells don’t necessarily age the same way – it all depends on their genetic material and environment. The researchers found that cells can age either through DNA stability decline or mitochondrial decline.

Biologist David Sinclair takes 7 supplements and 2 prescription medications to boost longevity. Here’s his full supplement stack.