Lifeboat Foundation

A genetic editing system similar to CRISPR-Cas9 has been uncovered for the first time in eukaryotes – the group of organisms that include fungi, plants, and animals. The system, based on a protein called Fanzor, can be guided to precisely target and edit sections of DNA, and that could open up the possibility of its use as a human genome editing tool.

The research team, led by Professor Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard, began to suspect that Fanzor proteins might act as nucleases – enzymes that can chop up nucleic acids, like DNA – during a previous investigation.

Continue reading “Newfound CRISPR-Like System In Animals Could Be Used To Manipulate Human Genomes” »

The arrangement of electrons in matter, known as the electronic structure, plays a crucial role in fundamental but also applied research, such as drug design and energy storage. However, the lack of a simulation technique that offers both high fidelity and scalability across different time and length scales has long been a roadblock for the progress of these technologies.

Researchers from the Center for Advanced Systems Understanding (CASUS) at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) in Görlitz, Germany, and Sandia National Laboratories in Albuquerque, New Mexico, U.S., have now pioneered a machine learning–based simulation method that supersedes traditional electronic structure simulation techniques.

Their Materials Learning Algorithms (MALA) software stack enables access to previously unattainable length scales. The work is published in the journal npj Computational Materials.

Interesting discovery! I’d love to see it in action.

A new ferroelectric polymer that efficiently converts electrical energy into mechanical strain has been developed by Penn State researchers. This material, showing potential for use in medical devices and robotics, overcomes traditional piezoelectric limitations. Researchers improved performance by creating a polymer nanocomposite, significantly reducing the necessary driving field strength, expanding potential applications.

A new type of ferroelectric polymer that is exceptionally good at converting electrical energy into mechanical strain holds promise as a high-performance motion controller or “actuator” with great potential for applications in medical devices, advanced robotics, and precision positioning systems, according to a team of international researchers led by Penn State.

Continue reading “Artificial Muscles Flex for the First Time: Ferroelectric Polymer Innovation in Robotics” »

Plants have the unique ability to regenerate entirely from a somatic cell, i.e., an ordinary cell that does not typically participate in reproduction. This process involves the de novo (or new) formation of a shoot apical meristem (SAM) that gives rise to lateral organs, which are key for the plant’s reconstruction.

At the cellular level, SAM formation is tightly regulated by either positive or negative regulators (genes/protein molecules) that may induce or restrict shoot regeneration, respectively. But which molecules are involved? Are there other regulatory layers that are yet to be uncovered?

To seek answers to the above questions, a research group led by Nara Institute of Science and Technology (NAIST), Japan studied the process in Arabidopsis, a plant commonly used in genetic research. Their research—which was published in Science Advances —identified and characterized a key negative regulator of shoot regeneration.

The mesh has already proved successful on fruit fly larvae in Minnesota, and with two species of mushroom coral in Hawaii and Australia. In Florida, Hagedorn and colleagues were trying it on Diploria labyrinthiformis, a kind of brain coral whose larvae are more than 100 times bigger than those of mushroom coral. In the first few attempts, rewarmed larvae were falling apart. Each larval size, Hagedorn was learning, needs its own version of the treatment. “We’re struggling a little bit to get this to work,” she says.

WHILE SCIENTISTS such as Bischof and Hagedorn wrestle with vitrification, others are seeking an easier route by avoiding ultralow temperatures that require large infusions of cryoprotectant and make rewarming so challenging.

At Harvard University and MGH, scientists are taking cues from nature to push tissues below freezing while holding back the ice. The wood frog (Rana sylvatica) is a champion of this realm. Found in much of North America, including the frigid Canadian Arctic, it can spring to life after spending months with as much as two-thirds of its body frozen at temperatures as low as −16°C.

Each time our cells divide, the protective caps that keep our chromosomes from fraying, called telomeres, lose a bit of their DNA. Telomeres shorten steadily as we age, but in certain medical conditions like dyskeratosis congenita, the process is accelerated.

“Your telomeres determine your lifeline; how long they are determines how old your body is,” says Becca Hudson, who was diagnosed with dyskeratosis congenita at age 14. “My telomere length was below the first percentile for my age.”

Trying out for cheerleading, 14-year-old Becca was pulled when testing found something amiss with her blood work. She had very low counts of platelets, red cells, and white cells. Her doctor called later that day and said she should be admitted that night to Boston Children’s Hospital.

A bit long 😪

Anyone can have a Mastodon server. People turned their backs on Tom, whose Myspace was the best space. Zuckerberg copied both Tom and the Twins. I rejoined Myspace after Facebook started harrassing my account because of the Virality Project because I questioned the popular vaccines, and told people how long it took to create an effective vaccine, and the effectiveness of the BCG vaccine I took as an infant. They silenced me.

In this group even before Musk paid for Twitter I posted about Mastodon, an open source Twitter option, and I still will pay for a blue tick. I won’t pay for anything Zuckerberg does what Mastodon already did, and people line up like sheep, yet… More.

Continue reading “Fully Managed Mastodon Hosting” »

Discovering new materials and drugs typically involves a manual, trial-and-error process that can take decades and cost millions of dollars. To streamline this process, scientists often use machine learning to predict molecular properties and narrow down the molecules they need to synthesize and test in the lab.

Researchers from MIT and the MIT-Watson AI Lab have developed a new, unified framework that can simultaneously predict molecular properties and generate new molecules much more efficiently than these popular deep-learning approaches.

To teach a machine-learning model to predict a molecule’s biological or mechanical properties, researchers must show it millions of labeled molecular structures—a process known as training. Due to the expense of discovering molecules and the challenges of hand-labeling millions of structures, large training datasets are often hard to come by, which limits the effectiveness of machine-learning approaches.

Welcome to this week’s installment of The Intelligence Brief… in recent days, DARPA has announced a new program that aims to protect warfighters from bloodstream infections caused by bacterial and fungal agents. This week, we’ll be examining 1) the announcement of the agency’s new SHIELD program, 2) past challenges that inspired the new DARPA initiative, and 3) how they say SHIELD will manage to clean your bloodstream, similar to a Roomba.

Quote of the Week

Continue reading “DARPA’S New SHIELD Program Plans to Purge Your Blood of Pathogens, Roomba-Style” »