Lifeboat Foundation

Stem cells are valuable to a wide range of biomedical and pharmaceutical research applications because of their high self-renewal and differentiation potential. But working with human stem cells is not easy. For starters, they are high-maintenance and expensive to culture. They also need to be constantly monitored, to ensure they remain pluripotent, viable and homogeneous. In order to set yourself up for success, firstly, you need a precise and gentle way to isolate stem cells.

Challenges of stem cell isolation

Stem cells are cultured in the lab using specialized “recipes” that vary depending on the application. For example, adult cells can be reprogrammed into pluripotent stem cells (iPSCs) by adding cofactors like Oct3/4, KLF4, Sox2 and c-Myc1. Along the way, stem cells are isolated for routine testing to make sure they have the expected features.

Stumbling across seashells and sea creatures is commonplace while on a trip to Florida, but finding a message in a bottle seems like something straight out of a storybook.

Brent Coleman, his 13-year-old son Garrison, and his friend, 13-year-old Lane McCall, had traveled from Georgia for a vacation when they came across a bottle while walking on Bradenton Beach, as reported by WFLA.

Inside the bottle was a handwritten note from a man named Howard Brown. He had written that he would have loved to live a life in Florida with his wife of 57 years, but “cancer had other plans.” The note continued, stating that by the time someone found the bottle, he would be gone.

As researchers make major advances in medical care, they are also discovering that the efficacy of these treatments can be enhanced by individualized approaches. Therefore, clinicians increasingly need methods that can both continuously monitor physiological signals and then personalize responsive delivery of therapeutics.

Implanted bioelectronic devices are playing a critical role in these treatments, but there are a number of challenges that have stalled their widespread adoption. These devices require specialized components for signal acquisition, processing, data transmission, and powering.

Up to now, achieving these capabilities in an implanted device has entailed using numerous rigid and non-biocompatible components that can lead to tissue disruption and patient discomfort. Ideally, these devices need to be biocompatible, flexible, and stable in the long term in the body. They also must be fast and sensitive enough to record rapid, low-amplitude biosignals, while still being able to transmit data for external analysis.

An Israeli startup has developed a wearable device that can predict the likelihood of an imminent stroke through changes in the carotid artery’s blood flow, potentially helping early intervention and preventing disablity.

Strokes are most commonly caused by a clot blocking the essential supply of blood to the brain, and according to the World Health Organization are the second leading cause of death and the leading cause of disability across the globe.

Continue reading “Wearable Device Predicts Stroke, Saving Crucial Treatment Time” »

Working on your muscles could help delay the onset of Alzheimer’s symptoms, researchers have revealed.

Researchers from the Federal University of São Paulo and the University of São Paulo in Brazil have uncovered strong evidence that resistance training – where muscles are worked against a weight or a force – could have significant consequences for the brains of dementia patients.

Before you hurriedly renew your gym membership or break out the home exercise equipment, it’s worth bearing in mind that this was a mouse model study. Nevertheless, the same principles are likely to apply to humans.

A new robotic system promises to bring the best out of human surgeons by allowing them to use their feet along with their hands during a laparoscopic operation.

Some surgeries are so complex and tiresome that while performing them doctors may wish they could have four arms. Laparoscopy is one such operation, it is used to diagnose and treat various problems in the abdomen and pelvis region.

Continue reading “In a first, a robotic system makes four-arm laparoscopy feasible for surgeons” »

These soft-bodied machines are poised to revolutionize confined space tasks and biomedical applications.

Scientists at MIT have achieved a major milestone in robotics by creating tiny soft-bodied robots that can be controlled using a simple magnetic field. These remarkable robots, constructed from flexible magnetic spirals, have the ability to walk, crawl, and even swim, all in response to an easily applicable magnetic force.

Professor Polina Anikeeva, leading the team of researchers behind this innovative creation, expressed her excitement: “This is the first time this has been done, to be able to control three-dimensional locomotion of robots with a one-dimensional magnetic field.”

A new study by researchers at the University of Cambridge reveals a surprising discovery that could transform the future of electrochemical devices. The findings offer new opportunities for the development of advanced materials and improved performance in fields such as energy storage, brain-like computing, and bioelectronics.

Electrochemical devices rely on the movement of charged particles, both ions and electrons, to function properly. However, understanding how these charged particles move together has presented a significant challenge, hindering progress in creating new materials for these devices.

In the rapidly evolving field of bioelectronics, soft conductive materials known as conjugated polymers are used for developing medical devices that can be used outside of traditional clinical settings. For example, this type of materials can be used to make wearable sensors that monitor patients’ health remotely or implantable devices that actively treat disease.

There are many different definitions of aging, but scientists generally agree upon some common features: Aging is a time-dependent process that results in increased vulnerability to disease, injury and death. This process is both intrinsic, when your own body causes new problems, and extrinsic, when environmental insults damage your tissues.

Your body is comprised of trillions of cells, and each one is not only responsible for one or more functions specific to the tissue it resides in, but must also do all the work of keeping itself alive. This includes metabolizing nutrients, getting rid of waste, exchanging signals with other cells and adapting to stress.

The trouble is that every single process and component in each of your cells can be interrupted or damaged. So your cells spend a lot of energy each day preventing, recognizing and fixing those problems.