Lifeboat Foundation

The opioid epidemic in the United States has exacted an incalculable toll on individuals and communities, creating an urgent need for alternative painkillers. The search for non-opioid treatments is crucial, not only to mitigate the risks of addiction and overdose, but also to develop pain management tools that remain effective without inducing tolerance and other challenging side effects in patients.

New research from the University of Chicago identified an alternative signaling pathway in the brain of mice that relieves pain, even in animals that have developed tolerance to opioids.

The study, titled “A Cholinergic Circuit That Relieves Pain, Despite Opioid Tolerance” and published in Neuron, also showed that pain relief through this route did not induce tolerance, did not create withdrawals symptoms after treatment was stopped, and did not activate reward systems, limiting risk for addiction and making it a viable path to developing effective, non-opioid pain relief.

You’re looking at a truck. You’re with a young child and he follows your gaze. He’s interested in the object you’re looking at without you pointing at it. This is called joint attention and it is one of the primary ways children learn to connect words with objects and acquire language.

Lack of joint attention is a core feature of autism. Until now, it was thought that stimulating joint attention in people with autism would help them express themselves verbally. But a meta-analysis of 71 studies on autism challenges this assumption and suggests that people with autism spectrum disorders may acquire language differently.

The study—by Laurent Mottron, a professor in the Department of Psychiatry and Addiction at Université de Montréal and a psychiatrist at the Hôpital en santé mentale Rivière-des-Prairies of the CIUSSS du Nord-de-l’Île-de-Montréal; Mikhail Kissine, a professor of linguistics at Université Libre de Bruxelles; and Ariane St-Denis, a medical student at McGill University—is published in Neuroscience & Biobehavioral Reviews.

Fresh from solving the protein structure challenge, Google’s deep-learning outfit is moving on to the human genome.

Google DeepMind researchers recently developed a technique to improve math ability in AI language models like ChatGPT by using other AI models to improve prompting—the written instructions that tell the AI model what to do. It found that using human-style encouragement improved math skills dramatically, in line with earlier results.

In a paper called “Large Language Models as Optimizers” listed this month on arXiv, DeepMind scientists introduced Optimization by PROmpting (OPRO), a method to improve the performance of large language models (LLMs) such as OpenAI’s ChatGPT and Google’s PaLM 2. This new approach sidesteps the limitations of traditional math-based optimizers by using natural language to guide LLMs in problem-solving. “Natural language” is a fancy way of saying everyday human speech.

A team of researchers in Japan claims to have figured out a way to translate the clucking of chickens with the use of artificial intelligence.

As detailed in a yet-to-be-peer-reviewed preprint, the team led by University of Tokyo professor Adrian David Cheok — who has previously studied sex robots — came up with a “system capable of interpreting various emotional states in chickens, including hunger, fear, anger, contentment, excitement, and distress” by using “cutting-edge AI technique we call Deep Emotional Analysis Learning.”

They say the technique is “rooted in complex mathematical algorithms” and can even be used to adapt to the ever-changing vocal patterns of chickens, meaning that it only gets better at deciphering “chicken vocalizations” over time.

With advanced technology and proper medical care, one can live without pancreas and lead a normal lifestyle.

The Toyota Research Institute (TRI) has unveiled a ground-breaking generative AI method that enables the rapid and efficient teaching of new and improved dexterous skills to robots.

This is according to a press release by the organization published on Tuesday.

Astronomers say they have spotted evidence of stars fuelled by the annihilation of dark matter particles. If true, it could solve the cosmic mystery of how supermassive black holes appeared so early.

By Jonathan O’Callaghan

At the 2015 Conference of the Mormon Transhumanist Association, held 3 Apr 2015 at the Salt Lake City Public Library, speakers addressed the themes of Mormonism, Transhumanism and Transfigurism, with particular attention to topics at the intersection of technology, spirituality, science and religion. Members, friends and critics of the association have many views. This is one of them. It is not necessarily shared by others.