Lifeboat Foundation

Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. They know that spherical collections of fats, called protocells, were the precursor to cells during this emergence of life. But how did simple protocells first arise and diversify to eventually lead to life on Earth?

Now, Scripps Research scientists have discovered one plausible pathway for how protocells may have first formed and chemically progressed to allow for a diversity of functions.

The findings, published online on February 29, 2024, in the journal Chem, suggest that a chemical process called phosphorylation (where phosphate groups are added to the molecule) may have occurred earlier than previously expected. This would lead to more structurally complex, double chained protocells capable of harboring chemical reactions and dividing with a diverse range of functionalities. By revealing how protocells formed, scientists can better understand how early evolution could have taken place.

Alex Rosenberg is the R. Taylor Cole Professor of Philosophy at Duke University. His research focuses on the philosophy of biology and science more generally, mind, and economics.

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In a new study, scientists have mapped magnetic fields in galaxy clusters, revealing the impact of galactic mergers on magnetic-field structures and challenging previous assumptions about the efficiency of turbulent dynamo processes in the amplification of these fields.

Galaxy clusters are large, gravitationally bound systems containing numerous galaxies, hot gas, and dark matter. They represent some of the most massive structures in the universe. These clusters can consist of hundreds to thousands of galaxies, bound together by gravity, and are embedded in vast halos of hot gas called the intracluster medium (ICM).

ICM, consisting mainly of ionized hydrogen and helium, is held together by the gravitational pull of the cluster itself. Magnetic fields in large-scale structures, like galaxy clusters, play pivotal roles in shaping astrophysical processes. They influence the ICM, impact galaxy formation and evolution, contribute to cosmic ray transport, participate in cosmic magnetization, and serve as tracers of large-scale structure evolution.

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study focusing on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders. The research, published in Frontiers in Immunology, identifies a specific enzyme known as PRMT5, as a key regulator of suppressive activity in a specialized population of cells.

The human immune system is a marvel of evolution. When a pathogen enters the body, immune cells can identify it, call for backup, attack the pathogen, and then, when the threat has been eradicated, return to a peaceful state. But sometimes, as in the rare autoimmune disorder aplastic anemia, something goes wrong.

In patients with aplastic anemia, the aberrant immune cells, in this case Th1 cells, misidentify healthy stem cells in bone marrow as pathogenic and attack them. Without these bone marrow stem cells, the body can’t make white blood cells to fight infections, red blood cells to carry oxygen throughout the body, or platelets that help stop bleeding.

We now have a standard model of cosmology, the current version of the Big Bang theory. Although it has proved very successful, its consequences are staggering. We know only 5% of the content of the universe, which is normal matter. The remaining 95% is made up of two exotic entities that have never been produced in the laboratory and whose physical nature is still unknown.

These are dark matter, which accounts for 25% of the content of the cosmos, and dark energy, which contributes 70%. In the standard model of cosmology, dark energy is the energy of empty space, and its density remains constant throughout the evolution of the universe.

According to this theory, sound waves propagated in the very early universe. In those early stages, the universe had an enormous temperature and density. The pressure in this initial gas tried to push the particles that formed it apart, while gravity tried to pull them together, and the competition between the two forces created sound waves that propagated from the beginning of the universe until about 400,000 years after the Big Bang.

Researchers report in the journal Cell that ancient viruses may be to thank for myelin—and, by extension, our large, complex brains.

The team found that a retrovirus-derived genetic element or “retrotransposon” is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed “RetroMyelin,” is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.

“Retroviruses were required for vertebrate evolution to take off,” says senior author and neuroscientist Robin Franklin of Altos Labs-Cambridge Institute of Science. “If we didn’t have retroviruses sticking their sequences into the vertebrate genome, then myelination wouldn’t have happened, and without myelination, the whole diversity of vertebrates as we know it would never have happened.”

Polyploidization-rediploidization process plays an important role in plant adaptive evolution. Here, the authors assemble the genomes of mangrove species Sonneratia alba and its inland relative Lagerstroemia speciosa, and reveal genomic evidence for rediploidization and adaptive evolution after the whole-genome triplication.

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Heme proteins can catalyze the formation of carbon–silicon bonds.

Dr. David Cohen comments on 10-year results from a trial of transcatheter vs. surgical aortic valve replacement:

Over the past decade, transcatheter aortic valve replacement (TAVR) has evolved from a niche procedure to treat severe aortic stenosis in high-risk patients to a mainstream procedure that is also performed in intermediate-and low-risk patients. With this evolution in practice, the large number of younger patients with life expectancies 10 years now receiving TAVR has raised concerns about its durability and patients’ long-term outcomes. Now, 10-year results are available from the NOTION trial of TAVR versus surgical aortic valve replacement (SAVR) that was conducted between 2009 and 2013 (NEJM JW Cardiol May 29 2015 and J Am Coll Cardiol 2015; 65:2184).

Two hundred eighty patients aged 70 years (mean age, 79 years; mean predicted risk of surgical mortality, 3%) were randomized to SAVR using any commercially available bioprosthesis or TAVR using the first-generation self-expanding CoreValve device. At 10-year follow-up, there was no significant between-group difference in the composite of death, stroke, or myocardial infarction (66% for both groups) or any of the individual components. Rates of bioprosthetic valve failure and repeat valve intervention were also similar. However, the rate of bioprosthetic valve dysfunction was lower with TAVR, largely reflecting lower rates of patient–prosthesis mismatch. The rate of structural valve deterioration was lower with TAVR as well, driven mainly by lower transvalvular gradients with TAVR that emerged early and persisted throughout follow-up.

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