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Researchers from the Center for Regenerative Medicine (CReM), a joint venture between Boston University and Boston Medical Center, have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19.

The two studies describing the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression appear online in Cell Stem Cell.

For more than 20 years, the scientists leading this work have pursued a way to engraft cells into injured lung tissues with the goal of regenerating lung airways or alveoli. They suspected that for engraftment to be long-lived and functional it would be important to reconstitute the stem or progenitor “compartments” of the lung, also sometimes known as stem cell niches.

A research team co-led by a physicist from City University of Hong Kong accurately measured the change in a nucleic acid induced by salt, temperature change and stretching force.

Vaccinations against tetanus and diphtheria, pneumococcus, and herpes zoster (HZ)- better known as shingles, are linked to a reduced risk of Alzheimer’s disease (AD). The corresponding study was published in the Journal of Alzheimer’s Disease.

Viral, bacterial, and fungal infections increase the risk of neuroinflammation, which may cause or exacerbate neurodegeneration and dementia. Vaccines may thus reduce neurodegeneration and dementia risk by reducing the risk of infection. Previous research, for example, shows that people who receive at least one influenza vaccine are 40% less likely than unvaccinated peers to develop AD.

Currently, the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) recommends older adults receive vaccines against tetanus, diphtheria and herpes zoster, and pneumococcus. The researchers behind the current study thus sought to see how these common vaccines may affect AD risk.

For C. Elegans, but but a cool use for the technology.

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Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary.

Continue reading “The Million Molecule Challenge To Find The Next Longevity Treatment | Prof Matt Kaeberlein Ep4” »

Most of us who’ve reached middle age have noticed a slowing in memory and cognition, but scientists don’t have a clear picture of the molecular changes that take place in the brain to cause it.

Now, a study in mice has determined that the most pronounced changes occur in the white matter, a type of nervous system tissue that’s integral to transmitting signals across the brain. The study also examined two treatments — caloric restriction and infusions of plasma from young mice — that affect certain regions of the brain, with the plasma appearing to slow the age-related decline.

Continue reading “Stanford Medicine-led research identifies gene ‘fingerprint’ for brain aging” »

New bionic hand with better move of fingers.

Successful testing of the bionic hand has already been conducted on a patient who lost his arm above the elbow.

In a world first, surgeons and engineers have developed a new bionic hand that allows users with arm amputations to effortlessly control each finger as though it was their own body.

Continue reading “New bionic hand allows amputees to effortlessly control fingers” »

The “chemical cocktail” helped reverse aging in mice, but some experts are skeptical about whether it will work in humans.

The viral ALS Ice Bucket Challenge a few years ago raised major funding that resulted in the discovery of new genes connected to the disease. One of those genes is NEK1, in which mutations have been linked to as much as 2% of all ALS cases, making it one of the top-known causes of the disease.

But it wasn’t known how the mutated gene disrupts the function of the motor neuron and causes it to degenerate and die.

Northwestern Medicine scientists have discovered for the first time how this mutated gene leads to ALS (amyotrophic lateral sclerosis).

We know that humans are an intelligent species. But this biologist breaks down the intelligence of each of our cells — and it will blow your mind.

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Continue reading “Can cells think? | Michael Levin” »