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Archive for the ‘biotech/medical’ category: Page 166

Aug 25, 2023

Screening during IVF for inherited diseases greatly reduces costs of care

Posted by in categories: biotech/medical, genetics, health

For prospective parents who are carriers of many inherited diseases, using in vitro fertilization along with genetic testing would significantly lower health care expenditures, according to researchers at Stanford Medicine.

Preimplantation genetic diagnostic testing during IVF, or PGD-IVF, is being used to screen for single-gene defect conditions such as cystic fibrosis, sickle cell disease and Tay-Sachs disease, along with nearly 400 others.

Continue reading “Screening during IVF for inherited diseases greatly reduces costs of care” »

Aug 25, 2023

Common hormone could hold key to treating endometrial cancer

Posted by in category: biotech/medical

New research from QIMR Berghofer has found that the hormone testosterone may play an important role in the development of endometrial cancer.

The discovery raises exciting new possibilities for screening, preventing and fighting this increasingly prevalent disease.

Continue reading “Common hormone could hold key to treating endometrial cancer” »

Aug 25, 2023

How mRNA Could Safely Replace Blood Stem Cell Transplantation

Posted by in categories: biotech/medical, chemistry, genetics, life extension

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.

Aug 25, 2023

Naked Mole Rats’ Longevity Gene Successfully Transferred to Mice

Posted by in categories: biotech/medical, life extension

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

Aug 25, 2023

Team identifies 169 genes associated with production of melanin in the skin, hair and eyes

Posted by in categories: biotech/medical, genetics

A team of geneticists and systems biologists at Stanford University has associated 169 genes that with the production of melanin in the skin, hair and eyes. In their study, reported in the journal Science, the group conducted a flow cytometry analysis and genome-wide CRISPR screen of cell samples.

Prior research has shown that the production and distribution of melanin in the body is responsible for , and eye pigmentation. Such characteristics are important for more than appearance’s sake; skin with more melanin, for example, is better able to protect against . In this new effort, the researchers noted that while many of the genes responsible for melanin production have been identified, many more have not.

The researchers began with an effort to differentiate high and low melanin melanocytes—the cells that make melanin. They used the light-reflecting properties of melanin to sort cells in a lab dish by aiming a fluorescent lamp at them. Once they had the cells sorted, they edited them using CRISPR-Cas9. Genes were systematically mutated to switch them off and then tested to see how well the cell continued to produce melanin.

Aug 25, 2023

A map of every conceivable molecule could be possible with AI

Posted by in categories: biotech/medical, chemistry, robotics/AI

A map of all chemicals that places compounds with similar properties next to each other could speed up the process of discovery for everything from drugs to materials.

By Karmela Padavic-Callaghan

Aug 25, 2023

Kids Who Are Always on iPads Missing Developmental Goals, Scientists Find

Posted by in categories: biotech/medical, entertainment, mobile phones

Parents who limit their kids’ screen time, it seems, may be doing them a service: a new study has found that babies who spend a lot of time looking at iPads and other screens experience developmental delays.

Published this week in the Journal of the American Medical Association of Pediatrics, this new research out of Japan suggests that watching screens may limit infants’ practicing of real-life motor skills that they glean from mimicking the people near them.

In a questionnaire, the parents of the more than 7,000 kids surveyed were asked a simple question: “On a typical day, how many hours do you allow your children to watch TV, DVDs, video games, internet games (including mobile phones and tablets), etc?”

Aug 24, 2023

Unintended Effects of Anti-Cancer Drugs

Posted by in category: biotech/medical

Drug development is a huge component of healthcare research that continues to grow, however, about 90% of drugs generated fail to make it to clinical trials. Drugs designed to target cancer fail due to many different obstacles including the tumor microenvironment (TME), which is the area surrounding the tumor. The TME is comprised of multiple cells generated to suppress the immune system and allow the tumor to grow. Since there are many mechanisms involved that makeup the TME, it is difficult to prescribe patients anti-cancer drugs that completely kill the tumor. Often a combination therapies are needed, but doctors run the risk of adverse side effects in patients due to toxicity of too many drugs.

Recently, a study published in eLife from Dr. Jennifer Gerton at the Stowers Institute for Medical Research in Kansas City, Missouri reported one critical reason why patients may experience unexpected side effects on the cellular level.

Aug 24, 2023

Bat biotech takes flight

Posted by in category: biotech/medical

Fascinating discussion of how biotech companies (esp. Paratus) and academic researchers are leveraging the unique immunobiology of bats to find new ways of treating inflammation, cancer, infections, metabolic diseases, and more. Exploration through comparative genomic approaches as well as newly created bat iPSCs is yielding mechanistic discoveries that could inform the medicines of tomorrow. #biotech #molecularbiology #genomics #stemcells


Harnessing the unusual biology of bats, researchers aim to turn drug discovery upside-down.

Aug 24, 2023

Immune cell discovery could lead to improved chronic worm treatment

Posted by in category: biotech/medical

Monash University researchers have uncovered why some intestinal worm infections become chronic in animal models, which could eventually lead to human vaccines and improved treatments.

Parasitic worms, also called helminths, usually infect the host by living in the gut. About a quarter of the world population is afflicted with helminth infections.

They are highly prevalent in developing countries such as sub-Saharan Africa, South America and some tropical countries in Asia. In Australia, they can be a problem in First Nations communities.

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