Researchers at the Icahn School of Medicine at Mount Sinai have found that small populations of pancreatic cancer cells can create localized immune-protective niches that shield tumors from immune attack. The finding could open new avenues for making immunotherapy more effective against one of the deadliest forms of cancer.
The findings, published in Nature, show that a small number of pancreatic cancer cells activate genes that stabilize fibrin, a protein that forms a meshwork involved in blood clotting.
The study reveals that cancer cells use this wound-healing system to build a protective environment that prevents cancer-fighting immune cells from reaching pancreatic tumors. In preclinical models, disrupting this protective mechanism slowed tumor growth and improved responses to immunotherapy, pointing to a potential strategy for overcoming pancreatic cancer’s resistance to immune-based treatments.
“With IBD, and with other many diseases that we collaborate with other groups to study, there [are] some treatments, but maybe those treatments still are not maybe the best or the most targeted that we can do because we … fundamentally don’t understand the disease fully.”
With its black casing, grey hoses and a plethora of wires, the microscope is remarkably unobtrusive.
Yet this is no run-of-the-mill bit of tech: the microscope operates at 10 times the resolution of conventional light microscopy, allowing researchers to see the details down to just 20nm in size.
http://www.ted.com Onstage at TED2012, Peter Diamandis makes a case for optimism — that we’ll invent, innovate and create ways to solve the challenges that loom over us. \.
The conversation focused on the unprecedented wave of technological disruption brought about by advances in artificial intelligence, exploring how these innovations are reshaping the social contract, the workforce, and the very fabric of society. One concept discussed was the collapse of traditional pathways—such as the idea that doing well in school and earning a college degree guarantees security and a stable job—in the face of rapidly evolving AI capabilities.
A key theme that emerged was the dual-edged nature of AI’s impact: while automation and intelligent machines threaten to displace conventional jobs, particularly for those unable or unwilling to adapt, new opportunities are arising for solopreneurs, creators, and individuals ready to leverage technology as a force multiplier. The discussion explored the ways gatekeepers have been removed, the costs of entrepreneurship have plummeted, and barriers to innovation are lower than ever before.
Several points were raised, including the psychological and societal turbulence that can result from such rapid change, with concerns about social unrest, especially among younger generations struggling to find their place. The conversation also addressed the promise of AI to solve critical problems in healthcare, science, and education, potentially ushering in an era of abundance—but only if society can adjust mindsets, update educational systems, and encourage purpose-driven curiosity.
Listeners can expect a deep dive into the ethical, economic, and cultural fork in the road humanity faces, as well as practical advice for achieving agency, adaptability, and meaning in a world where the only constant is exponential change.
Get the exact systems, mindset shifts, and principles that built a $1B brand delivered straight to your inbox every week. Subscribe for free (https://tombilyeu.com)
Check out our Video game — Project Kyzen: (https://projectkyzen.io/) Catch Me Streaming on Twitch — (/ tombilyeu)
In this episode of Impact Theory with Tom Bilyeu, Tom sits down with visionary entrepreneur and futurist Peter Diamandis to explore the cutting-edge intersections of technology, health, and consciousness. They dive deep into thought-provoking topics such as the potential of living to 150, the transformative power of AI-driven medical breakthroughs, and the exciting prospects of human colonization of the moon, Mars, and even O’Neill colonies in space. Peter shares his insights on the rapid advancements in AI, quantum computing, and longevity science, promising a new era of abundance and health. Tune in as they discuss how these innovations could redefine human potential, challenge our perceptions of life and health, and pave the way for an extraordinary future. Whether you’re an entrepreneur, a dreamer, or a tech enthusiast, this conversation offers a fascinating glimpse into the future of humanity. Don’t miss this inspiring episode full of visionary ideas and groundbreaking possibilities!
The difference in approach on tackling AI progress is likely to be a central issue when Xi and Trump meet Sept. 24 in Washington.
Amodei’s essay came just a few days after U.S. agencies published an alert saying that top China AI companies have systematically copied cutting-edge AI models from American companies.
Beijing rejected this accusation that its companies had been “distilling” U.S. models.
