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Abstract: Glioblastoma remains profoundly resistant to current immunotherapeutic strategies

Here, Fanghui Lu & team report OLIG2, a master transcription factor in glioblastoma stem cells, enables immune evasion by suppressing CXCL10. And, targeting OLIG2 overcomes immunotherapy resistance and improves survival.

1Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

2Department of Neurosurgery, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

3School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

The homogenizing effect of large language models on human expression and thought

AI chatbots are homogenizing human expression and risk reducing humanity’s collective wisdom, computer scientists and psychologists say. http://spkl.io/6181AI6Jh.

TrendsInCognitiveScience.

Cognitive diversity, reflected in variations of language, perspective, and reasoning, is essential to creativity and collective intelligence. This diversity is rich and grounded in culture, history, and individual experience. Yet, as large language models (LLMs) become deeply embedded in people’s lives, they risk standardizing language and reasoning. We synthesize evidence across linguistics, psychology, cognitive science, and computer science to show how LLMs reflect and reinforce dominant styles while marginalizing alternative voices and reasoning strategies. We examine how their design and widespread use contribute to this effect by mirroring patterns in their training data and amplifying convergence as all people increasingly rely on the same models across contexts.

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research

For decades, the field of biogerontology has largely focused on a single strategy: manipulating metabolism to slow down the rate at which we age. While approaches like caloric restriction have produced fascinating results in short-lived organisms like worms and flies, they have shown clear limits in mammals. Slowing the accumulation of damage does not remove the damage that is already there. It merely delays (not prevents) the onset of disease, particularly when applied late in life.

This Spacetime Quasicrystal Could Solve Physicists’ Biggest Problem

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What is space, really? That’s one of the biggest questions in science. According to a pair of researchers from the Perimeter Institute, the answer to that is: a quasicrystal. What is a quasicrystal, and how is space a quasicrystal? Let’s take a look.

Paper: https://arxiv.org/abs/2601.

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📩 Free weekly science newsletter ➜ https://sabinehossenfelder.com/newsle… Audio only podcast ➜ https://open.spotify.com/show/0MkNfXl… 🔗 Join this channel to get access to perks ➜ / @sabinehossenfelder 📚 Buy my book ➜ https://amzn.to/3HSAWJW #science #sciencenews #spacetime #physicsteacher What is space? That’s one of the biggest questions, not just in the foundations of physics, but in all of science. According to a new paper, the answer may be a quasicrystal, an idea from researchers working on quantum gravity. This video explores the implications of this idea, touching on concepts like String Theory and Loop Quantum Gravity, to understand what it might mean for theoretical physics.
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#science #sciencenews #spacetime #physicsteacher.

What is space? That’s one of the biggest questions, not just in the foundations of physics, but in all of science. According to a new paper, the answer may be a quasicrystal, an idea from researchers working on quantum gravity. This video explores the implications of this idea, touching on concepts like String Theory and Loop Quantum Gravity, to understand what it might mean for theoretical physics.

Continue reading “This Spacetime Quasicrystal Could Solve Physicists’ Biggest Problem” | >

Palladium-Catalyzed Asymmetric Oxidative Amination of Internal α,β-Unsaturated Esters with Lewis Basic AminesClick to copy article linkArticle link copied!

Chiral amines are privileged chiral building blocks with extensive applications in pharmaceuticals, advanced materials, and asymmetric catalysis owing to their unique structural features and functional diversity. Although palladium-catalyzed asymmetric allylic C–H amination offers an efficient strategy for constructing these motifs, the simultaneous challenges of coordinating sterically hindered internal alkenes and suppressing catalyst deactivation by Lewis basic amines have severely limited the development of asymmetric oxidative amination systems. In this study, we disclose a novel ester, an unmodified native functional group-directed strategy that enables the palladium-catalyzed asymmetric oxidative allylic amination of internal α,β-unsaturated esters with basic amines. This protocol yields a diverse array of non-natural γ-amino acid derivatives with excellent yields and high enantioselectivity (93% to >99% e.e.). Comprehensive mechanistic investigations, incorporating controlled experiments and density functional theory calculations, elucidate the intricate reaction pathway. The synthetic utility is further demonstrated through various product derivatizations and the streamlined synthesis of bioactive compounds. This work establishes a general platform for accessing enantioenriched nitrogen-containing architectures from readily available alkenes and amines.

Watching quantum behavior in action: MagnetoARPES reveals time-reversal symmetry breaking in a kagome superconductor

Electron movement and structures described in quantum physics allow researchers to better understand how and why materials like superconductors behave as they do. Rice University researchers Jianwei Huang and Ming Yi have developed a new capability, magnetoARPES, building on angle-resolved photoemission spectroscopy (ARPES) that allows researchers to study quantum behaviors they have been unable to resolve using ARPES alone. The work has been published in Nature Physics.

MagnetoARPES adds a tunable magnetic field, external to the sample, to ARPES. This allows researchers to probe the full electronic response to a magnetic field, giving insights into why certain collective behaviors of electrons develop.

Magnetic fields have, historically, been excluded from ARPES experiments, but over the course of a few years of experimentation and simulations, Yi’s team found a viable way to incorporate this capability into the ARPES sample environment.

Oval orbit casts new light on black hole–neutron star mergers

Scientists have uncovered the first robust evidence of a black hole and neutron star crashing together but orbiting in an oval path rather than a perfect circle just before they merged. This discovery challenges long-standing assumptions about how these cosmic pairs form and evolve.

Researchers from the University of Birmingham, Universidad Autónoma de Madrid, and Max Planck Institute for Gravitational Physics published their findings today (11 Mar) in The Astrophysical Journal Letters.

Most neutron star-black hole pairs are expected to adopt circular orbits long before merging. But the analysis of the gravitational-wave event GW200105 shows that this system traveled on an oval orbit long before merging to form a black hole 13 times more massive than the sun. An oval orbit is something never seen before in this kind of collision.

Abstract: In 2015, Philip M

Murphy & colleagues reported on a patient with WHIM syndrome who was cured of the disease by a spontaneous somatic genetic event that deleted the mutant CXCR4 allele in a single hematopoietic stem cell.

Here, the team now show CRISPR silencing of the Cxcr4 overactive disease allele corrects leukopenia in a murine model of WHIM syndrome, demonstrating a new therapeutic strategy for dominant immune disorders.

Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.

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