Lifeboat Foundation

Scientists from the HIV Cure Center at the UNC School of Medicine, University of California San Diego, Emory University, and University of Pennsylvania have been searching for where exactly these latent cells are hiding in the body. New research published in the Journal of Clinical Investigations confirms that microglial cells – which are specialized immune cells with a decade-long lifespan in the brain – can serve as a stable viral reservoir for latent HIV.

Yuyang Tang, PhD, and Guochun Jiang, PhD, in the UNC School of Medicine extracted living brain tissue to conclude that specialized immune cells in the brain can harbor latent but replication-competent HIV.

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency.

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Background

Many everyday tasks can fall under the mathematical class of “hard” problems. Typically, these problems belong to the complexity class of nondeterministic polynomial (NP) hard. These tasks require systematic approaches (algorithms) for optimal outcomes. In the case of significant complex problems (e.g., the number of ways to fix a product or the number of stops to be made on a delivery trip), more computations are required, which rapidly outgrows cognitive capacities.

A recent Science Advances study investigated the effectiveness of three popular smart drugs, namely, modafinil (MOD), methylphenidate (MPH), and dextroamphetamine (DEX), against the difficulty of real-life daily tasks, i.e., the 0–1 knapsack optimization problem (“knapsack task”). A knapsack task is basically a combinatorial optimization task, the class of NP-time challenging problems.

Synthetic human embryos – derived from stem cells without the need for eggs or sperm – have been created for the first time, scientists say. The structures represent the very earliest stages of human development, which could allow for vital studies into disorders like recurrent miscarriage and genetic diseases. But questions have been posed about the legal and ethical implications, as the pace of scientific discovery outstrips the legislation.

The breakthrough was reported by the Guardian newspaper following an announcement by Professor Magdalena Żernicka-Goetz, a developmental biologist at the University of Cambridge and Caltech, at the 2023 annual meeting of the International Society for Stem Cell Research. The findings have not yet been published in a peer-reviewed paper.

It’s understood that the synthetic structures model the very beginnings of human development. They do not yet contain a brain or heart, for example, but comprise the cells that would be needed to form a placenta, yolk sac, and embryo. Żernicka-Goetz told the conference that the structures have been grown to just beyond the equivalent of 14 days of natural gestation for a human embryo in the womb. It’s not clear whether it would be possible to allow them to mature any further.

Non-invasive methods, such as EEG and fNIRS, offer safer alternatives for BCI applications but must overcome obstacles related to signal quality and specificity.

The brain is regarded as one of the most complex known structures in the universe. It has billions of neurons, trillions of connections, and multiple levels ranging from cellular to molecular and synaptic. But the biggest challenge is that the brain is difficult to access.

“The brain is encased in a thick bone,” said Kinney, “and if you try to access, poke, or prod it, it will get really upset and hemorrhage, and delicate neurons will die.”

Nevertheless, Kinney said progress is being made on various fronts, particularly in the field of recording brain activity, which is good news for those trying to build brain-like computers.

A new study published in Psychological Science investigated the relationship between loneliness, brain activity, and social interactions. The results suggest that individuals who experience loneliness may process social information differently from those who do not, contributing to feelings of isolation and disconnection.

The study highlights the importance of social connection for psychological well-being. It emphasizes the need for further research in this area to develop effective interventions to help individuals experiencing loneliness improve their social connections and overall quality of life.

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The minds of social species are strikingly resonant.

A study in Australia found that men with anxiety disorders tended to have reduced bone mineral density in their lumbar spine and femoral neck bones. This association was found even when controlling for sociodemographic, biometric and lifestyle factors, other diseases, and medication use, but disappeared when participants with a history of mood disorders were excluded from the sample. The study was published in Acta Psychiatrica Scandinavica.

Bone mineral density refers to the quantity of minerals, primarily calcium and phosphorus, present in a segment of bone. It serves as an indicator of bone strength and density.

Studies have shown that certain psychiatric disorders might negatively impact bone health. These include unipolar depression, bipolar disorder, schizophrenia and anorexia nervosa. A meta-analytic review of 21 studies conducted in 2016 reported a very clear link between depression and reduced bone mineral density in several regions.

Scientists from a collection of Chinese research institutions collaborated on a study of organ regeneration in mammals, finding deer antler blastema progenitor cells are a possible source of conserved regeneration cells in higher vertebrates. Published in the journal Science, the researchers suggest the findings have applications in clinical bone repair. With the activation of key characteristic genes, it could potentially be used in regenerative medicine for skeletal, long bone or limb regeneration.

Limb and organ regeneration is a long coveted technology in medical science. Humans have some limited regenerative abilities, mostly in our livers. If a portion of the liver is removed, the remaining liver will begin to grow until it reaches its original functional size. Lungs, kidneys, and pancreas can do this also, though not as thoroughly or efficiently.

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