We live longer and longer, and as we age, a lot of us develop a series of health issues and chronic diseases, including Chronic Obstructive Pulmonary Disease (COPD), which is found in around 600 million individuals globally. However, only half of them know they have the disease.

COPD patients often experience shortness of breath, persistent cough with mucus, wheezing and frequent respiratory infections, which can make everyday activities difficult.

Now a new study from the University of Copenhagen and Bispebjerg Hospital suggests that a form of vitamin B3 may be the key to improving quality of life for these patients.

“In the study, we show that nicotinamide riboside, also known as vitamin B3, can reduce lung inflammation in COPD patients,” says Associate Professor Morten Scheibye-Knudsen from the Center for Healthy Aging at the Department of Cellular and Molecular Medicine, University of Copenhagen, who has co-authored the new study.

A new study carried out by researchers at the University of Copenhagen and Bispebjerg Hospital shows that a form of vitamin B3 can reduce lung inflammation in COPD patients.

In this Review, Della Valle et al. discuss the role of retrotransposable elements (RTEs) in the onset and progression of ageing and ageing-related disease, including evidence that environmental stressors act through RTEs to shift the trajectory towards unhealthy ageing.

Japanese researchers are making groundbreaking discoveries on the mechanisms of aging and working to apply them. As we age, senescent cells, or aged cells that have stopped dividing, accumulate, causing inflammation that can damage blood vessels and organs. Animal experiments have shown that removing these cells improves kidney function and reduces arteriosclerosis. They have led to the identification of a drug and development of a vaccine to eliminate the cells.

Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD⁺, yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal that supplementation with the NAD ⁺ precursor nicotinamide riboside (NR) markedly reprograms metabolic and stress-response pathways that decline with aging through inhibition of the clock repressor PER2. NR enhances BMAL1 chromatin binding genome-wide through PER2 ^K680 deacetylation, which in turn primes PER2 phosphorylation within a domain that controls nuclear transport and stability and that is mutated in human advanced sleep phase syndrome.

Scientists created a stem cell-based method to produce high-quality mitochondria at scale, enabling effective treatments for osteoarthritis and other diseases linked to mitochondrial dysfunction. Scientists have developed a groundbreaking method to mass-produce high-quality human mitochondria, a