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Australian researchers have developed a new method to reprogram human cells to better mimic embryonic stem cells called transient-naive-treatment (TNT).

Stem cells, serving as a repair system for our body, generate all other cells with specialized functions. There are two main types of stem cells: embryonic stem cells and adult stem cells.

In a scientific advancement in the 2000s, it was discovered that somatic cells, which are responsible for the growth and development of an organism, could be artificially reprogrammed into a state that resembles embryonic stem (ES) cells, also known as induced pluripotent stem (iPS) cells. These cells can then generate any cell in the body.

A genetically modified pig kidney transplanted into a brain-dead man on life support has exhibited regular functioning for over a month, showing no signs of rejection or infection.

A new milestone in animal-to-human organ transplants in the United States has been achieved.

A gene-edited pig kidney implanted into a brain-dead man on life support has been functioning normally for over a month with no signs of rejection or infection.

Older adults with more severe behavioral symptoms, including agitation, aggression, and disinhibition, are more likely to become divorced than those with less severe symptoms. However, increasing stages of dementia are associated with a low likelihood of divorce. These are some of the conclusions of a new study published August 16 in the open-access journal PLOS ONE by Joan Monin of the Yale School of Public Health and colleagues.

In recent years, divorce has been on the rise among older adults. Moreover, dementia can be difficult for married couples for many reasons, including the introduction of caregiving burden, loss of intimacy, and financial strain.

In a new study, researchers analyzed data from 37 NIA/NIH Alzheimer’s Disease Research Centers (ADRCs) across the US. The final study included 263 married or living-as–married couples who were divorced or separated during their follow up period at an ADRC, as well as 1,238 age-matched controls.

This is a SURVEY result of Rapamycin users. Overall, it’s really good for you. It has not had a true trial as it is off-patent so it’s harder to get rich from it. Low dose use has minimal side effects if any at all. Many patients can get off-label prescription from their doctor.

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Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement.

Continue reading “Rapamycin Update What You Need To Know | Prof Matt Kaeberlein Ep1” »

According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid receptor alpha (RARα), is known to control gene expression programs in the nucleus, but it also now appears to operate outside the cell nucleus to coordinate the early events triggered at the cell surface that lead to T cell activation.

Scientists wouldn’t normally expect to see a nuclear receptor such as RARα playing this role outside the cell nucleus. And yet the new findings suggest T cells cannot begin to fight disease without a form of RARα on the scene in the cytoplasm.

“Cytoplasmic retinoic acid receptors turn out to be central for a T cell to link sensing at the cell surface with downstream signaling cascades and gene expression programs that transform the T cell to become an active fighter,” says Professor Hilde Cheroutre, Ph.D., who led the new study at La Jolla Institute for Immunology (LJI) with LJI Assistant Professor Samuel Myers, Ph.D., LJI Professor Mitchell Kronenberg, Ph.D., and LJI Professor Emeritus Amnon Altman, Ph.D.

Researchers from Monash University in Melbourne and The University of Western Australia have demonstrated how a reprogramming method imitates embryonic epigenetic reset. Transient naive treatment (TNT) reprogrammed human induced pluripotent stem (hiPS) cells that are molecularly and functionally more similar to human embryonic stem (hES) cells than primed hiPS cells, which are more like cells in the post-implantation embryo. This research suggests that TNT reprogramming has the potential to set a new standard for therapeutic and biomedical uses.

The research article “Transient naive reprogramming corrects hiPS cells functionally and epigenetically” was published online today in Nature.

“Our work shows that TNT reprogramming is a practical and scalable approach to overcome these intrinsic characteristics of hiPS cells, which is important for the clinical delivery of this technology,” stated the authors. “We foresee TNT reprogramming becoming a new standard for biomedical and therapeutic applications.”

DISCLOSURE: Longevity. Technology (a brand of First Longevity Limited) has been contracted by the company featured in this article to support its current funding round. Qualifying investors can find out more via the Longevity. Technology investor portal.

This week’s Longevity Summit Dublin is in full swing, bringing together experts from around the world, fostering collaboration and knowledge exchange in the pursuit of solutions to extend human healthspan. One of the speakers during today’s sessions was Stanford professor and surgeon, Dr Vinit Mahajan, who is also Chief Medical Advisor for longevity biotech startup Mitrix Bio.

In his address to summit delegates in Dublin, Mahajan presented the company’s fascinating preclinical technology: bioreactor-grown mitochondria designed to be transplanted into the human body to regenerate organs, reverse age-related disease, and support other longevity therapies.

Since 2014, the ALS Ice Bucket Challenge has inspired more than 17 million people to raise $115 million for The ALS Association, which has funded over 500 research projects with the money. Because of that boost, the first drug to treat ALS has been approved by the FDA, other new treatments are in testing, and scientists have been able to identify several genes that are connected to the disease.

While mutations in a gene called NEK1 have only been associated with around two percent of ALS cases, it is one of the primary genetic causes of ALS that have been revealed so far. Now investigators have learned more about how NEK1 mutations can lead to ALS, a disease in which the motor neurons that control movement degenerate and die, which causes paralysis and eventually, death. The work has been reported in Science Advances.

Researchers at the National Heart, Lung, and Blood Institute at NIH, Bethesda, have discovered a potential breakthrough for people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), marked by extreme exhaustion, post-exertional malaise and cognitive issues.

In a paper, “WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome,” published in PNAS, the team details the influence of increased WASF3 proteins on the assembly of mitochondrial proteins, hampering energy production.

The study focused on a woman (S1) who experienced severe long-term fatigue. Measuring her muscles for phosphocreatine regeneration after exercise revealed a significant delay in mitochondrial ATP synthesis capacity. This discovery was followed up with a cell assay which found increased phospho-activation of an enzyme in a signaling pathway (MPAK).