Noticing somebody fidgeting can be distracting. Vexing. Even excruciating. But why?
According to research, the stressful sensations caused by seeing others fidget are an incredibly common psychological phenomenon, affecting as many as one in three people.
Called misokinesia – meaning ‘hatred of movements’ – this strange phenomenon had been little studied by scientists until recent years, but was noted in the context of a related condition, misophonia: a disorder where people become irritated upon hearing certain repetitious sounds.
Rao et al. found that lactylation stimulates the proteasomal degradation of cGAS independent of ubiquitin, which is compromised by phosphorylation of PSMA4 via disrupting its association with cGAS. Lactylation rewires PIK3CB activity and impairs ULK1-driven phosphorylation of PSMA4. Consequently, lactylation of cGAS sustains tumor growth and indicates the prognosis of LUAD.
The classic definitions of bundle branch and fascicular block have been established without consideration if conduction block is complete or incomplete (conduction delay). Current electrocardiographic (ECG) definitions cannot distinguish pronounced conduction delay (first-degree block) from complete conduction block. We are presenting here 2 cases of first-degree left bundle branch block (LBBB) that may be relevant when interpreting findings and observations during conduction system pacing.
The narrow groove theory was proposed in 1965 by J. H. Vohr and C. Y. Chow, two engineers at New York-based Mechanical Technology, Inc. The theory explains the working of herringbone grooved journal bearings, or HGJBs – a type of air-lubricated bearing that supports rotating parts in mechanical systems.
Many different types of bearings exist, but HGJBs hold the most promise for developing ultrahigh-speed rotating machines because the rotor is supported on a cushion of air generated by the rotating shaft.
