Congratulations to Yang (Claire) Zeng and her team for their work on DoriVac, a DNA origami vaccine which utilizes precisely spaced CpG oligonucleotides to enhance immunological responses against chosen antigens.
The spacing of ligands presented to cells can have a huge impact on cellular responses. DNA origami is used to block structures to control the distribution of Toll-like receptor ligands and optimize presentation in the activation of dendritic cells in cancer immunotherapy.
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