Dr. Stefanie Dimmeler
Dr. Stefanie Dimmeler, winner of the 1.55 million euro
2005 Leibniz Prize,
received her graduate and Ph.D. degree in molecular cardiology at the
Konstanz. She then completed a fellowship in Experimental Surgery
University of Cologne and in Molecular Cardiology at the
University of Frankfurt. She
is professor of
Experimental Medicine and head of the Section of Molecular Cardiology
University of Frankfurt since 2001. She is author of more than 120
papers, all of which
published in highly qualified journals, including Nature,
Research, and Blood.
Stefanie is on the editorial boards of Circulation, Circulation Research, Basic Research in Cardiology, and Journal of Molecular and Cellular Cardiology. Her research is predominantly focused on endothelial biology, including signal transduction, apoptosis, and renewal by circulating endothelial progenitor cells in health and disease. She identified novel signalling pathways by which the synthesis of the endothelial protective factor nitric oxide is released. Together with Dr. Zeiher, she is responsible for the scientific discoveries culminating in current clinical trial of human progenitor cells for cardiac repair.
She authored Mechanism regulating endothelial progenitor cell homing and differentiation, and coauthored Endothelial Progenitor Cells Characterization and Role in Vascular Biology, Upregulation of Superoxide Dismutase and Nitric Oxide Synthase Mediates the Apoptosis-Suppressive Effects of Shear Stress on Endothelial Cells, Unchain my heart: the scientific foundations of cardiac repair, Regulation of Endothelial Cell Survival and Apoptosis During Angiogenesis, Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation, and Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells.