Dr. Stefanie Dimmeler
Dr. Stefanie Dimmeler, winner of the 1.55 million euro
2005 Leibniz Prize,
received her graduate and Ph.D. degree in molecular cardiology at the
University of
Konstanz. She then completed a fellowship in Experimental Surgery
at
the University of Cologne and in Molecular Cardiology at the
University of Frankfurt. She
is professor of
Experimental Medicine and head of the Section of Molecular Cardiology
at the
University of Frankfurt since 2001. She is author of more than 120
papers, all of which
published in highly qualified journals, including Nature,
Circulation,
Circulation
Research, and Blood.
Stefanie is on the editorial
boards of Circulation,
Circulation
Research,
Basic Research in Cardiology, and
Journal of
Molecular and Cellular Cardiology. Her research is
predominantly
focused on
endothelial biology, including signal transduction, apoptosis, and
renewal by circulating
endothelial progenitor cells in health and disease. She identified
novel signalling
pathways by which the synthesis of the endothelial protective factor
nitric oxide is released.
Together with Dr. Zeiher, she is responsible for the scientific
discoveries culminating in
current clinical trial of human progenitor cells for cardiac
repair.
She authored
Mechanism regulating endothelial progenitor cell homing and
differentiation, and
coauthored
Endothelial Progenitor Cells
Characterization and Role in Vascular Biology,
Upregulation of Superoxide Dismutase and Nitric Oxide
Synthase Mediates the Apoptosis-Suppressive Effects of
Shear Stress on Endothelial Cells,
Unchain my heart: the scientific foundations of cardiac
repair,
Regulation of Endothelial Cell Survival and Apoptosis
During Angiogenesis,
Upregulation of TRAF-3 by shear stress blocks CD40-mediated
endothelial
activation, and
Histone deacetylase activity is essential for the expression of
HoxA9
and for endothelial commitment of progenitor cells.
