Professor Mansour Mohamadzadeh
Mohamadzadeh, Ph.D. is Associate Professor of Medicine at
Northwestern University. His interests include
immunology, inflammation, medicine, and microbial pathogenesis.
One of the focuses of his laboratory is to elucidate inflammatory signals induced in mucosal innate and T cells by bacterial products (e.g., peptidoglycan, lipoteichoic acid, surface layer proteins) leading to intestinal colitis. Using gene targeting in probiotic bacteria he clearly shows the mitigation of colitis progression. Additionally, to mobilize mucosal and systemic immunity against microbial challenge he further optimizes various aspects of his mucosal multivalent-vaccine platform against a broad range of pathogens such as HIV, H1-N1, and Biodefense. This goal is achieved by directly targeting immunogens to small peptides derived from a phage display peptide library leading to efficiently capture by dendritic cells when expressed by probiotic bacteria at the mucosal side.
Mansour coauthored Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo, Proinflammatory Stimuli Regulate Endothelial Hyaluronan Expression and CD44/HAdependent Primary Adhesion, Induction of Hapten-specific Tolerance by Interleukin 10 In Vivo, Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells, and Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization.
Mansour earned his Ph.D. in Medicine at the Johannes Guttenberg University of Mainz, Germany in 1991. Founded in 1477, Mainz University is one of the oldest German universities. Mansour went on to complete a fellowship in medicine at the Southwestern Medical Center in Dallas.
Watch GOODBYE NEEDLE, HELLO SMOOTHIE! New generation oral vaccine uses dairy probiotics to protect against disease. Read Genetically Engineered Probiotics: A twist on a traditional therapy shows promise for treating bowel disease and Probiotics may offer more effective and less painful vaccinations.