Dr. Macsue Jacques
Macsue Jacques, PhD is a Postdoctoral Researcher at Monash University’s Australian Regenerative Medicine Institute (ARMI) and Data Scientist at Rejuve.AI, with expertise in epigenetics, biological aging, and multi-omics data analysis. She specializes in translational longevity research, clinical biomarker development, and the integration of advanced computational methods to understand how and why we age.
Macsue is known for her pioneering work on DNA methylation aging across multiple human tissues and her research demonstrating that exercise can rejuvenate the skeletal muscle methylome and transcriptome. She is the Cocreator and Cohost of Decoding Longevity, a podcast dedicated to making cutting-edge aging science accessible to the public.
As a Postdoctoral Researcher in Professor Nir Eynon’s laboratory at ARMI, Macsue uses advanced computational tools to explore the epigenetic basis of aging and exercise response in humans. Her work focuses on identifying robust, multi-tissue biomarkers of healthy aging that can be targeted by longevity-promoting interventions. She employs high-throughput methods, including DNA methylation profiling, proteomics, and transcriptomics, to investigate changes in gene and protein expression patterns across different tissues and populations. Read Landmark ‘ageing atlas’ reveals how your organs change.
In 2025, Macsue was the first author on a groundbreaking study titled DNA Methylation Ageing Atlas Across 17 Human Tissues, published in bioRxiv with leading aging researchers including Steve Horvath, Andrew Teschendorff, and Nir Eynon. This meta-analysis of more than 15,000 human methylomes spanning 17 tissues identified both conserved and tissue-specific aging signatures, revealing that most tissues show gradual shifts toward hypermethylation with age, while skeletal muscle and lung tissues buck this trend by losing methyl tags over time. The atlas, now freely available through an online portal, provides researchers worldwide with unprecedented insights into how different organs age at different rates.
Macsue has also contributed significantly to understanding exercise as a geroprotector. Her research demonstrates that exercise training leads to molecular “rejuvenation” of skeletal muscle, with individuals possessing higher baseline aerobic fitness showing younger epigenetic and transcriptomic profiles.
Her systematic review Epigenetic changes in healthy human skeletal muscle following exercise— a systematic review, published in Epigenetics in 2019, has become a foundational reference in the field with extensive citations. Read Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle and Exercise as a geroprotector: focusing on epigenetic aging.
As Data Scientist at Rejuve.AI since June 2025, Macsue develops AI-driven longevity tools and leads scientific initiatives for the decentralized longevity research network. She presented research on biological clocks derived from questionnaire data at the Aging Research and Drug Discovery (ARDD) conference in Copenhagen, Denmark, enabling personalized health insights even for individuals without blood tests.
In October 2025, she was announced as the scientific lead for Rejuve.AI’s groundbreaking biomarker study at the Infinite Games 2026, which will enroll more than 100 longevity athletes in Próspera, Honduras, to measure how different therapies, training regimens, and lifestyles impact biological aging. The study will collect multi-domain aging data, including biological age, epigenetic markers, blood biomarkers, physiological metrics, and lifestyle insights. She serves as a judge for the Longevity Biomarkers Competition alongside leading scientists in the regenerative medicine and longevity fields.
In May 2025, Macsue launched Decoding Longevity, a podcast cohosted with Dr. Raghav Sehgal from Yale University, dedicated to unraveling the mysteries of aging through clear, engaging conversations. Each episode breaks down the latest research papers in geroscience, offering insightful discussions on longevity, biological aging, and extending healthspan.
The podcast bridges the gap between complex longevity research and the broader public, making cutting-edge science accessible to scientists, enthusiasts, and anyone curious about living longer and healthier lives. Listen to Decoding Longevity on Spotify. Read ARMI Postdoc Launches Decoding Longevity, A New Anti-Ageing Science Podcast.
Throughout her career, Macsue has demonstrated exceptional leadership in the scientific community. Between July 2017 and December 2020, she served as Student Representative on the council of The Physiological Society (AuPS) in Australia. During her PhD, she was actively involved in leadership positions, including Student Council member at the HDR committee, and was later elected as an Australian Physiological Society council member. She facilitated numerous student events and served on organizing committees for major conferences, including Epigenetics 2021 (virtual), AuPS online student/ECR event 2020, ECR and student workshop for the AuPS conference 2019, and iHeS HDR conference 2018.
Macsue’s research has been published in high-impact peer-reviewed journals, including Aging Cell, The FASEB Journal, Journal of Cachexia, Sarcopenia and Muscle, Physiological Reports, and Epigenetics. Her work spans DNA methylation analysis, proteomics, transcriptomics, and integrative multi-omics approaches to understanding exercise response and aging. Read Methylome and proteome integration in human skeletal muscle uncover group and individual responses to high‐intensity interval training and Individual physiological and mitochondrial responses during 12 weeks of intensified exercise.
Macsue earned her PhD in Human Movement from Victoria University in 2021 with her thesis titled The epigenetics basis of variable response to exercise training and ageing. During her doctorate, she conducted extensive wet-lab and bioinformatics analyses, including DNA methylation and proteomics studies in skeletal muscle from human participants. She earned her Honours degree in Sports and Exercise Science (High Distinction) from Victoria University in 2016, receiving recognition as Most Outstanding Graduate Student in November 2017 for her Bachelor of Applied Science (Honors) in Human Movement.
Between August 2013 and December 2014, she participated in an Overseas Study Abroad Program at the University of Queensland in Australia, with emphasis on Clinical Exercise Physiology. She earned her Bachelor’s degrees in Biological Science and Sports Exercise Science from University Assis Gurgacz in Brazil in 2010, where her scientific initiation topic explored flexibility training in Rhythm Gymnastics athletes and their growing patterns.
Macsue is based in Australia and is passionate about demystifying science and making longevity research more inclusive and accessible. Through her work at ARMI, her role at Rejuve.AI, and her podcast, she is committed to advancing both the scientific understanding of aging and public awareness of evidence-based approaches to extending healthspan.
Listen to Decoding Longevity and visit the Decoding Longevity Podcast homepage.
Visit her LinkedIn profile, Google Scholar page, Victoria University research page, Monash University research profile, and Rejuve.AI profile. Follow her on Facebook, Instagram and X.