Professor Einar M. Sigurdsson
Einar M. Sigurdsson,
Ph.D. is Associate Professor at
Departments of Neuroscience and Physiology, NYU School of Medicine.
His current research focuses on pathogenesis, therapy, and diagnosis for age-related degenerative diseases, in particular Alzheimer’s and prion diseases and more recently type-2 diabetes. In these protein conformational disorders, a normal protein is converted to a pathological form with a high β-sheet structure. The scientific theme of his work is to study this conformational alteration, its consequences at the molecular and functional level, and the factors involved in this process.
Einar edited Amyloid Proteins (Methods in Molecular Biology) and coedited Amyloid Proteins: Methods and Protocols (Methods in Molecular Biology). His papers include Detection of Alzheimer’s amyloid in transgenic mice using magnetic resonance microimaging, Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer’s Disease-Associated Pathology in Transgenic Mice, Immunization delays the onset of prion disease in mice, Copper Chelation Delays the Onset of Prion Disease, Molecular targeting of Alzheimer’s amyloid plaques for contrast-enhanced magnetic resonance imaging, and β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer’s therapy. Read the full list of his publications!