Dr. Dmitry V. Bulavin

Dmitry V. Bulavin, M.D., Ph.D., is the Laboratory Head and Principal Investigator at the Institute for Research on Cancer and Aging (IRCAN) in Nice, France. Previously, he was the Principal Investigator and lead of his lab at The Institute of Molecular and Cell Biology (IMCB). His academic research is primarily in the field of cancer and aging molecular biology, with particular emphasis on the role of DNA damage and stress response signaling.

In 2004, Dmitry published a series of articles regarding the Wip1 phosphatase inhibition of tumorigenesis through p38 MAP kinase, and after establishing his lab in 2004 at IMCB in Singapore, he continued interrogating the role of Wip1 phosphatase in cancer but also in aging. Through generation and detailed analysis of multiple mouse models, his research established a key role of Wip1 phosphatase and p38 MAP kinase in several pathological conditions and in aging.

Since joining IRCAN in 2014, he has focused his research on the role of senescence in numerous pathological conditions including aging, stress response, and oncogenesis.

Dmitry earned his M.D. and Ph.D. from the Medical Academy in St. Petersburg, Russia. He carried out his postdoctoral training at the National Cancer Institute, NIH in the USA, where he established a role of p38MAPK in negative regulation of tumorigenesis and the key role of phosphatase Wip1 as a potent human oncogene — both directions are now widely pursued in the cancer field.

Dmitry is participating at the Undoing Aging 2019 Conference. In his talk, Dmitry is presenting the analysis of 2 novel knock-in mouse models that allow us to track and selectively eliminate senescent cells. He further discusses how this knowledge could help to improve anti-aging research.

Follow is a list of his more notable publications, with the ones in bold as the most relevant to his current research at IRCAN:

• p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis, Dec 2016
• Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions, May 2016
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Jan 2016
• Wip1 phosphatase in breast cancer, Nov 2014
• Oncogene-mediated regulation of p53 ISGylation and functions, Jul 2014
• Wip1 and ATM in tumor evolution: role for BRCA1, Dec 2013
• WIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation, Oct 2013
• Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium, Jan 2013
• Apoptosis Differently Affects Lineage Tracing of Lgr5 and Bmi1 Intestinal Stem Cell Populations, Feb 2013
• Wip1-Dependent Regulation of Autophagy, Obesity, and Atherosclerosis, Jul 2012
• Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging, Jun 2014
• Wip1 Directly Dephosphorylates γ-H2AX and Attenuates the DNA Damage Response, May 2010
• p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age, Aug 2009
• Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control, Jun 2009
• WIP1 phosphatase is a negative regulator of NF-B signalling, May 2009
• Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine, Sep 2007
• Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways, Oct 2006
• Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis, Nov 2005
• A Subtle Change in p38 MAPK Activity is Sufficient to Suppress In Vivo Tumorigenesis, Feb 2005
• Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19 Arf pathway, May 2004
• p38 MAP kinase’s emerging role as a tumor suppressor, Feb 2004
• Dual phosphorylation controls Cdc25 phosphatases and mitotic entry, Jul 2003
• Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53, Jan 2003
• Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity, Jul 2002
• Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control, Mar 2002
• Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation, Dec 1999
• Genomic instability in Gadd45a-deficient mice, Nov 1999

Read his media coverage in EurekAlert after Dmitry uncovered a potential drug target to fight cancer.

Visit his ResearchGate, PubFacts, and Semantic Scholar profiles. Visit his lab homepage.