Dr. Brad Younggren
Brad Younggren, M.D. is the CEO and Cofounder of Circulate Health, a longevity company pioneering outpatient therapeutic plasma exchange (TPE) to advance human healthspan and lifespan. He is a Board-Certified Emergency Medicine Physician, a Fellow of the American College of Emergency Physicians (ACEP), and a decorated former U.S. Army combat physician with over two decades of experience at the intersection of medicine, technology, and entrepreneurship.
Brad is an Assistant Professor at WSU Elson S. Floyd College of Medicine, a practicing Emergency Physician and Director of Emergency Ultrasound at Evergreen Emergency Services in Kirkland, Washington, and a Commissioner on the Board of EvergreenHealth (King County Public Hospital District #2), where he chairs the Board Quality and Safety Committee.
As CEO of Circulate Health, Brad leads an expert team of clinicians and scientists working to harness the potential of therapeutic plasma exchange for longevity and chronic disease treatment. The company, cofounded with Eric Verdin, M.D., Ph.D., President and CEO of the Buck Institute for Research on Aging, is the first to bring therapeutic plasma exchange (TPE) into outpatient settings in the U.S. market, partnering with longevity and chronic disease clinics to provide this highly technical procedure directly to their patients.
Circulate Health originated as a research venture under Khosla Ventures, inspired by heterochronic parabiosis studies in rodents that demonstrated the rejuvenating effects of exchanging circulatory factors between young and old organisms.
In May 2025, Circulate Health and the Buck Institute published the results of a landmark single-blind, placebo-controlled human clinical trial in Aging Cell. The study, titled Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange, demonstrated that participants receiving biweekly TPE combined with intravenous immunoglobulin (IVIG) experienced an average biological age reduction of 2.6 years, as measured by multi-omics biomarkers across the epigenome, proteome, metabolome, glycome, and immune system.
Read Circulate Health Publishes Results of Multiomics Study Demonstrating Impact of Therapeutic Plasma Exchange on Biological Age in Aging Cell and Plasma Exchange in Humans Reduces Biological Age by Over Two Years.
Circulate Health has provided over 1,000 treatments since May 2024 and expanded to more than 22 affiliate clinics across eight states within 15 months, with international expansion underway. The company raised $12 million in seed funding led by Khosla Ventures, with participation from Seaside Ventures and CSC Ventures. Circulate has secured patents around its specific approach to improving healthspan and is conducting pioneering research into the removal of microplastics and nanoplastics from the body, claiming to hold what is likely the world’s largest dataset on the topic.
Circulate’s scientific advisory board includes David Furman, Ph.D., Director at the Buck Institute; Matt Kaeberlein, Ph.D., CEO of Optispan; Alex Aravanis, M.D., Ph.D., CEO of Moonwalk Biosciences; and Matthew Campen, Ph.D. Read Microplastics Are in Our Blood — Why Aren’t Federal Regulators Acting? and Circulate Health raises $12M for pricey ‘blood-cleaning’ longevity service.
Prior to founding Circulate in January 2024, Brad spent approximately eight years at 98point6 Technologies, a Seattle-based on-demand text-first virtual primary care company. He joined as Chief Medical Officer in 2017 and was promoted to President and Chief Medical Officer for Care Innovation in 2022, a role he held until 2024 before transitioning to an advisory position through 2025.
At 98point6, he led the development and launch of AI-powered primary care solutions delivered via a mobile application across all 50 U.S. states. The company raised over $129 million in venture funding and grew to serve more than 240 commercial partnerships accounting for three million members, including prominent brands such as Boeing, Sam’s Club, and Red Bull North America. Read Solving the Primary Care Shortage Challenge. Listen to Dr. Brad Younggren – Is Digital Care Better?
Before 98point6, Brad served as Chief Medical Officer at Cue Inc. (later known as Cue Health) between 2015 and 2017, where he helped develop their cutting-edge at-home lab testing platform, which saw rapid growth during the COVID-19 pandemic. He was also Chief Medical Officer at Shift Labs in 2015, a company developing low-cost medical devices for the global health market, deploying technology in Haiti and other countries, and has continued as Senior Medical Advisor since October 2015.
Between 2012 and 2015, Brad served as Chief Medical Officer at Mobisante in Redmond, Washington, where he helped develop the MobiUS, the first FDA-approved mobile phone medical device in the United States. The MobiUS was a smartphone-based ultrasound system that received FDA clearance in 2011 and represented a breakthrough in portable diagnostic imaging at a fraction of the cost of traditional systems. Read FDA Approves a Smartphone-Based Ultrasound System.
Alongside his startup leadership roles, Brad has maintained a continuous clinical presence at EvergreenHealth Medical Center in Kirkland, Washington. Since 2011, he has served as Medical Director of Emergency Preparedness and Associate Medical Director of the Trauma Program. He also served as Medical Director of Urgent Care between 2015 and 2019. Separately, he has practiced as an Emergency Physician and Director of Emergency Ultrasound at Evergreen Emergency Services since 2010.
Since January 2020, Brad has been an Assistant Professor at WSU Elson S. Floyd College of Medicine. Between 2012 and 2016, he served as Medical Director of Safe Kids Eastside through Safe Kids Worldwide, focusing on child injury prevention in the Kirkland community. He has been a State Disaster Medical Advisory Committee Member (DMAC) for the Washington Department of Health since 2016. Read Brad Younggren: Flipping the Clinic.
Brad earned his Bachelor’s Degree of Arts in Political Science in 1995 from the University of California, Los Angeles (UCLA), where he studied Latin American governments while completing his pre-medical education. He earned his M.D. in Medicine in 1999 from the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, Maryland.
Between 1999 and 2003, he earned a Diploma in the Medical Care of Catastrophes (DMCC) in Disaster Medicine from the Royal Society of the Apothecaries in London, United Kingdom. He holds certification in Advanced Trauma Life Support from the American College of Surgeons and certification in Health Care Administration, Leadership, and Management from the American Board of Emergency Medicine.
Brad served in the U.S. Army as a physician, beginning his military career after graduating from USUHS and completing his residency in Emergency Medicine at Madigan Army Medical Center. He served as Associate Program Director in the Department of Emergency Medicine at Madigan between 2003 and 2008.
During this period, he deployed to Tall’afar, Iraq, as Squadron Surgeon for 2–14 Cavalry, 1–25 Infantry Division (Stryker) between September 2004 and September 2005, serving as a combat physician during Operation Iraqi Freedom. For his service in Iraq, he was awarded the Bronze Star and the Combat Medical Badge in September 2004. He concluded his Army career as Assistant Chief of the Department of Emergency Medicine at Madigan between 2008 and 2010.
His wartime experiences with medical innovation and battlefield technology fundamentally shaped his career trajectory toward leveraging technology to scale healthcare delivery. In addition to his primary roles, Brad serves as a Board Member at Eastside Research Associates in Redmond, Washington, and at KardioGenics. He holds Strategic Advisor positions at Counsel Health, TBD Health, Alli Connect (formerly Thrivolution), and AI 2030. He is an Advisor at CalmWave and Violett, and an Expert at Primary Venture Partners. He is also a member of the AngelMD Scientific Advisory Board.
Previously, Brad was a Mentor at Highway1, a premier hardware startup accelerator, between 2013 and 2019, a Strategic Advisor at Blumio (acquired) between 2016 and 2022, an Advisor at Crescent Health (acquired), a Medical Advisor at Misceo Grand Technologies between 2016 and 2020, and an Advisor at CueMed Inc. between 2019 and 2025.
Brad has published academic articles including Comparison of cosyntropin versus caffeine for post-dural puncture headaches: A randomized double-blind trial in the World Journal of Emergency Medicine (2012), Ultrasound detection of pneumothorax with minimally trained sonographers: a preliminary study in the Journal of Special Operations Medicine, Emergency Management of Difficult Wounds: Part I in the Emergency Medicine Clinics of North America (2007), The evaluation and management of heat injuries in the emergency department in Emergency Medicine Practice, and Operation Castle Cascade: Managing multiple casualties from a simulated chemical weapons attack in the Journal of Military Medicine (2003). He has also contributed to publications on COVID-19 management in Seattle and off-service resident education in emergency departments.
Brad is a sought-after speaker on longevity, therapeutic plasma exchange, and healthcare innovation. He has presented at the RAADfest conference on multi-omics analysis of biological age rejuvenation with TPE, at Dent Santa Fe 2025 on the longevity horizon, at the Foresight Institute Longevity Biotech Seminar on how TPE can reverse age and age-related diseases, and at the American Telemedicine Association (ATA) Conference on virtual care delivery. He has also spoken at Google I/O Ignite on consumer-facing medical devices and at the Social Computing Symposium at Microsoft Research on medical devices for everyone.
Listen to Unlocking the Power of Therapeutic Plasma Exchange with Dr. Brad Younggren.
Read Redefining Longevity Medicine with Circulate Health’s Brad Younggren and Human trial finds therapeutic plasma exchange reduces biological age.
Brad is based in Seattle, Washington, and enjoys traveling through Central America with his twin daughters. He speaks English and Spanish and is passionate about designing global health solutions and extending healthy human lifespan. His causes include environment, health, disaster and humanitarian relief, poverty alleviation, and science and technology.
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