Dr. Antonei B. Csoka
B. Csoka, Ph.D. is
Department of Molecular and Cellular Biology
Roswell Park Cancer Institute, Buffalo, New York and
a Member of the Alcor Scientific Advisory Board.
He was featured in the first Immortality Institute film,
Antonei earned his B.S. in Genetics from the University of Newcastle, U.K. in 1991, his M.S. in Molecular Pathology and Toxicology from the University of Leicester, U.K. in 1993, and his Ph.D. in Cell and Molecular Biology from the University of Debrecen, Hungary in 1998.
He performed postdoctoral research at the University of California, San Francisco, where he cloned the human hyaluronidase genes, which are involved in fertilization, embryonic development, and cancer. As a postdoctoral research associate at Brown University from 2001 to 2003, he was a key player in the identification of the gene that causes Hutchinson-Gilford Progeria Syndrome (progeria), a disease with many features of “accelerated aging”. It is hoped that the identification of the gene for progeria will provide insights into the mechanisms of normal aging.
Antonei coauthored Genome-scale expression profiling of HutchinsonGilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/ mesenchymal defects and accelerated atherosclerosis, Lamin A/C Expression Is a Marker of Mouse and Human Embryonic Stem Cell Differentiation, Hyaluronidase reduces human breast cancer xenografts in SCID mice, and HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA.
As a postdoctoral associate at Roswell Park Cancer Institute, Antonei is developing animal models of progeria, studying the role of nuclear lamina dysfunction in human aging, and investigating the potential of stem cells and cellular reprogramming for the treatment of age-related diseases.
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