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Dr. Adiv A. Johnson

Adiv A. Johnson, Ph.D. is an independent aging researcher whose primary scientific interests include the mechanisms underlying human aging as well as therapies capable of extending human healthspan.

Adiv began his research career at the University of Arizona, where he procured his B.S. in Molecular and Cellular Biology in 2010 and his Ph.D. in Physiological Sciences in 2014. As an undergraduate, he investigated the effects of dietary restriction, resveratrol, and sirtuin inhibition on lifespan in mosquitoes. 

During his Ph.D., he investigated the pathogenic mechanisms underlying the bestrophinopathies, a set of diseases caused by mutations in the gene BEST1. One of these diseases – Best vitelliform macular dystrophy – is phenotypically similar to age-related macular degeneration. He additionally performed research relevant to the age-related ocular disease glaucoma. He completed a postdoctoral research fellowship at the Mayo Clinic in Minnesota, where he studied ocular regeneration in planarian flatworms and performed patient-specific disease modeling of retinal disease using human induced pluripotent stem cells. 

Throughout his research career, Adiv has engaged in research projects that explore the interplay between mesenchymal stem cells and aging, how extrinsic mortality affects the evolution of aging, the importance of lipid metabolism and aging, the ability of machine learning to generate aging clocks capable of accurately predicting age in human cohorts, and other topics. His primary research interests pertain to rejuvenation as well as the regulation of lifespan and healthspan.

The following are ten paper highlights from his larger list of publications:

  1. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging, 2020
  2. Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β, 2020
  3. Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue, 2020
  4. Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age, 2020
  5. The role of lipid metabolism in aging, lifespan regulation, and age-related disease, 2019
  6. Revamping the evolutionary theories of aging, 2019
  7. Migrational changes of mesenchymal stem cells in response to cytokines, growth factors, hypoxia, and aging, 2015
  8. Effects of extrinsic mortality on the evolution of aging: a stochastic modeling approach, 2014
  9. The role of DNA methylation in aging, rejuvenation, and age-related disease, 2012
  10. The impact of larval and adult dietary restriction on lifespan, reproduction, and growth in the mosquito Aedes aegypti,2010

For more information, please visit his Google Scholar and LinkedIn profiles. An expanded list of his publications can be found on PubMed.