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Dr. Adiv A. Johnson

Adiv A. Johnson, Ph.D.is an independent scientist that performs aging research as a hobby in his free time. His primary scientific interests are the mechanisms underlying human aging and therapies capable of improving human healthspan.

Adiv began his research career at the University of Arizona, where he obtained his B.S. in Molecular and Cellular Biology in 2010 and his Ph.D. in Physiological Sciences in 2014. He went on to complete a postdoctoral research fellowship in the Department of Ophthalmology at the Mayo Clinic in Minnesota.

During his Ph.D., he investigated the pathogenic mechanisms underlying the bestrophinopathies, a set of diseases caused by mutations in the gene BEST1. One of these diseases – Best vitelliform macular dystrophy – is phenotypically similar to age-related macular degeneration. He additionally performed research relevant to the age-related ocular disease glaucoma. He completed a postdoctoral research fellowship at the Mayo Clinic in Minnesota, where he studied ocular regeneration in planarian flatworms and performed patient-specific disease modeling of retinal disease using human induced pluripotent stem cells. 

Throughout his research tenure, Adiv has engaged in projects that explore the following topics: interventions that affect lifespan in mosquitoes, the interplay between mesenchymal stem cells and aging, the effects of extrinsic mortality on the evolution of aging, the relationship between lipid metabolism and aging, and the ability of machine learning models to predict biological age in human cohorts. His current research is focused on the ability of bioinformatics and machine learning to better understand aging and age-related disease.

The following are ten paper highlights from his larger list of publications:

  1. Modeling the human aging transcriptome across tissues, health status, and sex, 2021
  2. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging, 2020
  3. Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β, 2020
  4. Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue, 2020
  5. Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age, 2020
  6. The role of lipid metabolism in aging, lifespan regulation, and age-related disease, 2019
  7. Revamping the evolutionary theories of aging, 2019
  8. Effects of extrinsic mortality on the evolution of aging: a stochastic modeling approach, 2014
  9. The role of DNA methylation in aging, rejuvenation, and age-related disease, 2012
  10. The impact of larval and adult dietary restriction on lifespan, reproduction, and growth in the mosquito Aedes aegypti,2010

An expanded list of his publications can be found on PubMed and his Google Scholar page.