Advisory Board

Professor Nancy Manley

Nancy Manley, Ph.D. is Distinguished Research Professor of Genetics and Chair of UGA’s Developmental Biology Alliance.
 
Nancy is internationally recognized as an expert on the development, function, and aging of the thymus and parathyroid organs. These areas are highly relevant to the function of the immune and endocrine systems. She earned her Ph.D. from MIT under the direction of Drs. Nancy Hopkins and Philip Sharp, and did her postdoctoral training as an HHMI scholar under Dr. Mario Capeccchi at the University of Utah.
 
Nancy has carved a unique niche at the intersection of development, immunology, and aging. By using molecular genetic approaches to investigate the biology of the thymus across the entire lifespan, she has been able to uncover fundamental principles of organ development and aging, including mechanisms regulating stability of cell fate and degeneration of the immune system with aging. These principles have particular relevance to developing therapeutic interventions aimed at improving the immune system in the elderly by rejuvenating or replacing an aged thymus.
 
She was recently part of a research team that was the first to grow a fully functional thymus in a living animal from transplanted cells. This discovery could one day aid in the development of laboratory-grown replacement organs, and it may form the basis of a thymus transplant for people with weakened immune systems.
 
Her papers include The role of Hoxa-3 in mouse thymus and thyroid development, Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain, γ-Secretase inhibitors repress thymocyte development, Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment, Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch, and Developing a new paradigm for thymus organogenesis.
 
Read her LinkedIn profile.